Pleiotrophic effects of natural products in ROS-induced carcinogenesis: The role of plant-derived natural products in oral cancer chemoprevention

Ziech, Dominique; Anestopoulos, Ioannis; Hanafi, Rania; Voulgaridou, Georgia-Persephoni; Franco, Rodrigo; Georgakilas, Alexandros G.; Pappa, Aglaia; Panayiotidis, Mihalis Ι.

doi:10.1016/j.canlet.2012.02.025

Cited by 43 publications

(28 citation statements)

References 128 publications

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“…34,35 In the present study, MTT results indicated that Sg-AuNPs did not display any cytotoxicity to both the HaCaT and MCF7 cell lines. Therefore, Sg-AuNPs could be effectively employed to scavenge free radicals synthesized in the cell in response to multiple stresses.…”

Section: Assessment Of Antioxidant Activitysupporting

confidence: 42%

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Abbai¹,

Mathiyalagan²,

Markus³

et al. 2016

IJN

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Pharmacologically active stem of the oriental herbal adaptogen, Siberian ginseng, was employed for the ecofriendly synthesis of Siberian ginseng silver nanoparticles (Sg-AgNPs) and Siberian ginseng gold nanoparticles (Sg-AuNPs). First, for metabolic characterization of the sample, liquid chromatography-tandem mass spectrometry analysis (indicated the presence of eleutherosides A and E), total phenol content, and total reducing sugar were analyzed. Second, the water extract of the sample mediated the biological synthesis of both Sg-AgNPs and Sg-AuNPs that were crystalline face-centered cubical structures with a Z-average hydrodynamic diameter of 126 and 189 nm, respectively. Moreover, Fourier transform infrared analysis indicated that proteins and aromatic hydrocarbons play a key role in the formation and stabilization of Sg-AgNPs, whereas phenolic compounds accounted for the synthesis and stability of Sg-AuNPs. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) assay determined that Sg-AgNPs conferred strong cytotoxicity against MCF7 (human breast cancer cell line) and was only slightly toxic to HaCaT (human keratinocyte cell line) at 10 µg⋅mL −1 . However, Sg-AuNPs did not display cytotoxic effects against both of the cell lines. The disc diffusion assay indicated a dose-dependent increase in the zone of inhibition of Staphylococcus aureus (ATCC 6538), Bacillus anthracis (NCTC 10340), Vibrio parahaemolyticus (ATCC 33844), and Escherichia coli (BL21) treated with Sg-AgNPs, whereas Sg-AuNPs did not show inhibitory activity. In addition, the 2,2-diphenyl-1-picrylhydrazyl assay demonstrated that both Sg-AgNPs and Sg-AuNPs possess strong antioxidant activity. To the best of our knowledge, this is the first report unraveling the potential of Eleutherococcus senticosus for silver and gold nanoparticle synthesis along with its biological applications, which in turn would promote widespread usage of the endemic Siberian ginseng.

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Section: Assessment Of Antioxidant Activitysupporting

confidence: 42%

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Abbai¹,

Mathiyalagan²,

Markus³

et al. 2016

IJN

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show abstract

“…Compared to Gram-positive bacteria, Gram-negative bacteria are usually more resistant to commonly-used antibiotics as well as to plant secondary metabolites, having a complex cell wall, which acts as an effective permeability barrier to restrict the penetration of compounds. Furthermore a set of multidrug resistance pumps in their cell wall extrudes toxins across the outer membrane [11,22]. The highest antimicrobial activity was obtained with the methanol extract of aerial parts against M. luteus (MIC 3.5 μg mL -1 ).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…GC-FID and GC-MS analysis of a chloroform extract of aerial parts showed that the main volatile constituents were falcarinol, linoleic acid, hexadecanoic acid and methyl linoleate (comprising 32.6%; 24.4%; 19.9; 13.2% of the volatile fraction, respectively), while octanoic acid, tetradecanol and dodecanol dominated in the chloroform extract of the roots (34.9%; 25.8%; 22.2% of the volatile fraction, respectively). Investigation of antimicrobial activity by broth microdilution showed that the methanol and chloroform extracts of aerial parts and roots exerted a significant effect (MIC 3.5-15.6 µg mL -1 stress presents a risk to human health and can lead to the development of conditions such as cardiovascular diseases and cancer [11]. Plants are one of the most promising sources for discovering novel antimicrobial and antioxidant agents [11,12].…”

mentioning

confidence: 99%

“…Investigation of antimicrobial activity by broth microdilution showed that the methanol and chloroform extracts of aerial parts and roots exerted a significant effect (MIC 3.5-15.6 µg mL -1 stress presents a risk to human health and can lead to the development of conditions such as cardiovascular diseases and cancer [11]. Plants are one of the most promising sources for discovering novel antimicrobial and antioxidant agents [11,12]. Beside potential therapeutic values, investigations of E. palmatum provide valuable information about these vulnerable endemic species, helping to contribute to their future protection and conservation.…”

mentioning

confidence: 99%

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Composition, antimicrobial and antioxidant activity of the extracts of Eryngium palmatum Pančić and Vis. (Apiaceae)

et al. 2013

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The chemical composition, antimicrobial and antioxidant activity of Eryngium palmatum, an endemic plant species from the Balkan Peninsula, were investigated. The flavonoids apigenin (9.5±0.3 mg g−1) and apigenin 7-O-glucoside (2.4±0.1 mg g−1) were determined in a methanol extract of aerial parts using HPLC analysis. The methanol extract of roots contained catechin (5.0±0.1 mg g−1), epicatechin (2.9±0.1 mg g−1), chlorogenic acid (1.6±0.0 mg g−1), gallic acid (0.9±0.0 mg g−1) and rosmarinic acid (0.9±0.2 mg g−1). GC-FID and GCMS analysis of a chloroform extract of aerial parts showed that the main volatile constituents were falcarinol, linoleic acid, hexadecanoic acid and methyl linoleate (comprising 32.6%; 24.4%; 19.9; 13.2% of the volatile fraction, respectively), while octanoic acid, tetradecanol and dodecanol dominated in the chloroform extract of the roots (34.9%; 25.8%; 22.2% of the volatile fraction, respectively). Investigation of antimicrobial activity by broth microdilution showed that the methanol and chloroform extracts of aerial parts and roots exerted a significant effect (MIC 3.5–15.6 μg mL−1) against tested Gram-positive and Gram-negative bacteria. The methanol extracts of aerial parts or roots exerted moderate ferric reducing antioxidant power, DPPH radical scavenging activity and hydroxyl radical scavenging activity.

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“…These statistics emphasize the need for new treatment strategies. Currently, the mortality and morbidity rates of cancer remain high despite advances in surgical, chemical, radiation and hormone therapies, with associated adverse reactions and resistance (4).…”

Section: Introductionmentioning

confidence: 99%

PaCaHa inhibits proliferation of human cancer cells in vitro

Ekşi¹,

Ejder²,

Yılmaz³

et al. 2016

Turk J Med Sci

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Pleiotrophic effects of natural products in ROS-induced carcinogenesis: The role of plant-derived natural products in oral cancer chemoprevention

Cited by 43 publications

References 128 publications

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Composition, antimicrobial and antioxidant activity of the extracts of Eryngium palmatum Pančić and Vis. (Apiaceae)

PaCaHa inhibits proliferation of human cancer cells in vitro

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