Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase activities

Asiwe, Jerome Ndudi; Ojetola, Abodunrin Adebayo; Ekene, Nwoke Enekabokom; Osirim, Esthinsheen; Nnamudi, Anthony Chibuzor; Oritsemuelebi, Benjamin; Onuelu, Jackson Erozueme; Asiwe, Nicholas; Eruotor, Harrison Ogheneochuko; Inegbenehi, Saviour

doi:10.1016/j.chmed.2023.11.001

Chinese Herbal Medicines

2024

DOI: 10.1016/j.chmed.2023.11.001

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Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase activities

Jerome Ndudi Asiwe,

Abodunrin Adebayo Ojetola,

Nwoke Enekabokom Ekene

et al.

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Cited by 6 publications

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Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction

Pan,

Wang,

Lei

et al. 2024

Phytotherapy Research

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Myocardial infarction (MI) is a prevalent disease with high mortality rates worldwide. The course of MI is intricate and variable, necessitating personalized treatment strategies based on different mechanisms. However, variety of postoperative complications and rejections, such as heart failure, arrhythmias, cardiac rupture, and left ventricular thrombus, contribute to a poor prognosis. Despite the inclusion of antiplatelet agents and statins in the conventional treatment regimen, their clinical applicability is constrained by potential adverse effects and limited efficacy. Additionally, the mechanisms leading to MI are complex and diverse. Therefore, the development of novel compounds for MI treatment. The use of traditional Chinese medicine (TCM) in the prevention and treatment of cardiovascular diseases, including MI, is grounded in its profound historical background, comprehensive theoretical system, and accumulated knowledge. An increasing number of contemporary evidence‐based medical studies have demonstrated that TCM plays a significant role in alleviating symptoms and improving the quality of life for MI patients. Chinese herbal formulations and active ingredients can intervene in the pathological process of MI through key factors such as inflammation, oxidative stress, apoptosis, ferroptosis, pyroptosis, myocardial fibrosis, angiogenesis, and autophagy. This article critically reviews existing herbal formulations from an evidence‐based medicine perspective, evaluating their research status and potential clinical applications. Additionally, it explores recent advancements in the use of herbal medicines and their components for the prevention and treatment of MI, offering detailed insights into their mechanisms of action.

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Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction

Pan,

Wang,

Lei

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

Lutein protection against doxorubicin-induced liver damage in rats is associated with inhibition of oxido-inflammatory stress and modulation of Beclin-1/mTOR activities

Asiwe,

Yovwin,

Alawode

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism

Long,

Zhou,

et al. 2024

Chinese Herbal Medicines

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Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase activities

Cited by 6 publications

References 91 publications

Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction

Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction

Lutein protection against doxorubicin-induced liver damage in rats is associated with inhibition of oxido-inflammatory stress and modulation of Beclin-1/mTOR activities

Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism

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