Pleiotropic Biological Effects of Dietary Phenolic Compounds and their Metabolites on Energy Metabolism, Inflammation and Aging

Villegas-Aguilar, María del Carmen; Fernández-Ochoa, Álvaro; Cádiz-Gurrea, María de la Luz; Pimentel-Moral, Sandra; Lozano-Sánchez, Jesús; Arráez-Román, David; Segura‐Carretero, Antonio

doi:10.3390/molecules25030596

Cited by 34 publications

(20 citation statements)

References 125 publications

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“…Excessive production of pro-inflammatory cytokine can cause delayed wound healing. 30 Excessive production of ROS at wound sites produces toxic effects, causing inflammation and the degradation of repair mechanisms. 31 …”

Section: Discussionmentioning

confidence: 99%

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Arundina

Diyatri

Surboyo

et al. 2021

Journal of Taibah University Medical Sciences

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Objective The healing process of a traumatic ulcer requires growth factors to rebuild the lost tissue after the inflammatory process has been completed. Liquid rice hull smoke (LR-HS) has shown unique anti-inflammatory properties. This study analyses the role of LR-HS in growth factor stimulation for the healing of traumatic ulcers, such as fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and collagen type 1 (COL-1) expression. Methods We obtained LR-HS from the pyrolysis of rice hulls. Traumatic ulcers were created in the labial fornix incisive inferior of Wistar rats and treated with LR-HS once a day for 3, 5, and 7 days. The control group was treated with sterile water. Each animal was sacrificed after treatment, and its labial fornix incisive inferior tissues were biopsied and immunohistochemically stained to examine FGF, VEGF, PDGF, and COL-1 expression. Result The treatment of traumatic ulcers with LR-HS showed an increase in FGF, VEGF, PDGF, and COL-1 expression. VEGF expression increased under LR-HS treatment compared with the control 7-day treatment groups ( p < 0.000). FGF and COL-1 expression increased under LR-HS treatment compared with the control 5- and 7-day treatment groups ( p < 0.000). PDGF expression increased after treatment with LR-HS for 3, 5, and 7 days ( p < 0.000). Conclusion This study has demonstrated that LR-HS can induce the expression of growth factors during the healing of a traumatic ulcer using immunohistochemical staining. We suggest that LR-HS can be used as a herbal medicine for oral ulcer therapy.

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Section: Discussionmentioning

confidence: 99%

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Arundina

Diyatri

Surboyo

et al. 2021

Journal of Taibah University Medical Sciences

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“…This is strongly related to the wide range of biological activities like antioxidant, antimicrobial, anti-inflammatory, anti-allergenic, anticancer and cardioprotective activities. Thus, it has been reported that natural phenolic compounds and their metabolites exerted significant effects on the main metabolic pathways involved in energy metabolism (the AMP-protein kinase AMPK and the mammalian target of rapamycin mTOR are the main regulators), as well as inflammatory response and aging (main regulators are the nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and sirtuins) [ 25 , 26 ]. For example, Marín-Aguila et al (2013) described some nutraceutical compounds targeting AMPK pathways in cancer, cardiovascular disease, type 2 diabetes mellitus and neurodegenerative disease including phenolic acids, anthocyanins, stilbene, flavone, flavonol, alkaloids, lignan [ 26 ].…”

Section: Bioactive Compounds From Fruit By-productsmentioning

confidence: 99%

The Role of Fruit by-Products as Bioactive Compounds for Intestinal Health

Chaouch

Benvenuti

2020

Foods

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The fruit processing industry generates large amounts of wastes (pomace, seeds, peels) that causes negative environmental impact with considerable treatment expenses. Nevertheless, various studies demonstrated that these by-products are still rich in bioactive compounds, especially dietary fibres and phenolic compounds, thus leading to significant chemical, physical and biological properties. These characteristics make fruits by-products a good source for new supplements in food products having important effect on intestinal function. Thus, the aim of this review is to evaluate the different bioactive compounds isolated from fruit by-products and to analyse their application in various formulations for the food and nutraceutical industries. In consideration of the biological properties of these compounds, their role in the functioning and action on intestine and gut flora was discussed.

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“…Interestingly, bioactive compounds naturally present in plants, such as polyphenols, may offer such qualities. Indeed, in vitro and in vivo data from recent studies suggest potential benefits of polyphenols in reducing hepatic glucose output, enhancing muscle glucose uptake, restoring insulin signaling, and altering microbiome (11), which could result in pleiotropic beneficial effects (12). A sensible selection of extracts pooling several of these bioactive molecules could therefore allow a multitargeted action on the mechanisms involved in the pathogenesis of complex metabolic diseases such as T2D, offering an excellent tool to prevent them, as already suggested by other authors (13) and international health institutions (14,15).…”

Section: Introductionmentioning

confidence: 99%

Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study

Chavanelle¹,

Otero²,

Joubioux³

et al. 2021

American Journal of Physiology-Endocrinology and Metabolism

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Global prevalence of type 2 diabetes (T2D) is rising and may affect 700 million people by 2045. Totum-63 is a polyphenol-rich natural composition developed to reduce the risk of T2D. We first investigated the effects of Totum-63 supplementation in high-fat diet (HFD)-fed mice for up to 16 weeks, and thereafter assessed its safety and efficacy (2.5 g or 5 g per day) in 14 overweight men (mean age 51.5 years, BMI 27.6 kg.m-2) for 4 weeks. In HFD-fed mice, Totum-63 reduced body weight and fat mass gain while lean mass was unchanged. Moreover, fecal energy excretion was higher in Totum-63 supplemented mice, suggesting a reduction of calorie absorption in the digestive tract. In the gut, metagenomic analyses of fecal microbiota revealed a partial restoration of HFD-induced microbial imbalance, as shown by PCoA analysis of microbiota composition. HFD-induced increase in HOMA-IR score was delayed in supplemented mice, and insulin response to an OGTT was significantly reduced, suggesting that Totum-63 may prevent HFD-related impairments in glucose homeostasis. Interestingly, these improvements could be linked to restored insulin signaling in subcutaneous adipose tissue and soleus muscle. In the liver, HFD-induced steatosis was reduced by 40% (as shown by triglyceride content). In the subsequent study in men, Totum-63 (5g.day-1) improved glucose and insulin responses to a high-carbohydrate breakfast test (84% kcal carbohydrates). It was well tolerated, with no clinically significant adverse events reported. Collectively, these data suggest that Totum-63 could improve glucose homeostasis in both HFD-fed mice and overweight individuals, presumably through a multi-targeted action on different metabolic organs.

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Pleiotropic Biological Effects of Dietary Phenolic Compounds and their Metabolites on Energy Metabolism, Inflammation and Aging

Cited by 34 publications

References 125 publications

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

The Role of Fruit by-Products as Bioactive Compounds for Intestinal Health

Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study

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