Pleiotropic nature of curcumin in targeting multiple apoptotic‐mediated factors and related strategies to treat gastric cancer: A review

Abstract

Gastric cancer (GC) is one of the major reasons for cancer-associated death and exhibits the second-highest mortality rate worldwide. Several advanced approaches have been designed to treat GC; however, these strategies possess many innate complications. In view of this, the upcoming research relying on natural products could result in designing potential anticancer agents with fewer side effects. Curcumin, isolated from the rhizomes of Curcuma longa L. has several medicinal properties like antiinflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic. Such pleiotropic nature of curcumin impedes the invasion and proliferation of GC by targeting several oncogenic factors like p23, human epidermal factor receptor2 including Helicobacter pylori. The side effect of chemotherapy, that is, chemotherapeutic resistance and radiotherapy could be reduced combination therapy of curcumin. Moreover, the photodynamic therapy of curcumin destroys the cancer cells without affecting normal cells. However, further more potential studies are required to establish the potent efficacy of curcumin in the treatment of GC. The current review details the anticancer activities of curcumin and related strategies which could be employed to treat GC with additional focus on its inhibitory properties against viability, proliferation, and migration of GC cells through cell cycle arrest and stimulation by apoptosis-mediated factors.

The tibetan medicine Zuozhu-Daxi can prevent Helicobacter pylori induced-gastric mucosa inflammation by inhibiting lipid metabolism

“…It has been a field of current interest that diverse traditional medicines are evaluated for application against H. pylori. Many TCMs, such as turmeric, propolis, and garlic, have been reported to have anti-inflammatory, antioxidant, and antibacterial effects against H. pylori [53][54][55][56]. The anti-inflammatory and antioxidant effects of these medicines are mainly reflected in the inhibition of proinflammatory factors and reactive oxygen species generated by the interaction of H. pylori with gastric mucosa cells [15].…”

TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species

“…Human epidermal growth factor receptor 2 [143] Vascular endothelial growth factor receptor (VEGFR) [140,143] Vascular endothelial growth factor (VEGF) [140,143] Fibroblast growth factor (FGF) [136,140] Epidermal growth factor (EGF) [136,140,151] Platelet-derived growth factor (PDGF) [136] Ion channels and transporter signalling and biochemical pathways (Activation or inhibition depends on cell conditions (normal vs. injured/transformed) and types))…”

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

“…Curcumin(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5dione), also known as diferuloylmethane, is a natural compound found in the rhizome of Curcuma longa (turmeric) and some plants in the Araceae family. A number of studies have shown that curcumin has anti-cancer properties in vivo and in vitro [71][72][73][74]. These studies indicate that curcumin can inhibit cell proliferation and induce cell cycle arrest and apoptosis through a variety of mechanisms [72][73][74].…”

“…A number of studies have shown that curcumin has anti-cancer properties in vivo and in vitro [71][72][73][74]. These studies indicate that curcumin can inhibit cell proliferation and induce cell cycle arrest and apoptosis through a variety of mechanisms [72][73][74]. However, a major challenge in using curcumin to treat cancer is its bioavailability [71].…”