Pleiotropic protective effects of Vitamin D against high fat diet-induced metabolic syndrome in rats: One for all

Mostafa, Dalia K.; Nasra, Rasha A.; Zahran, Noha; Ghoneim, Mohammed T.

doi:10.1016/j.ejphar.2016.10.031

Cited by 23 publications

(18 citation statements)

References 49 publications

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“…Although these observations are in keeping with previous studies on the effects of vitamin D in animals fed with hypercaloric diets [ 13 , 14 , 26 ], much is still unknown about the specific mechanism(s) that may contribute to the observed beneficial effects.…”

Section: Discussionsupporting

confidence: 88%

“…Moreover, results from preclinical studies showed that vitamin D (or calcitriol) administration reduced the levels of blood glucose and improved insulin sensitivity in diabetic mice [ 12 ], attenuated the fibrosis and the increased expression of the receptor for advanced glycation end products (RAGE) in hearts of diabetic rats, and improved high fat diet-induced metabolic syndrome and reduced hepatic steatosis in rats [ 13 , 14 ]. We previously found that mice fed an high-fat-high sugar diet developed intra-muscular accumulation of both fat and advanced glycations end products (AGEs) in association with metabolic abnormalities [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice

et al. 2018

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Epidemiological studies pointed out to a strong association between vitamin D deficiency and type 2 diabetes prevalence. However, the role of vitamin D supplementation in the skeletal muscle, a tissue that play a crucial role in the maintenance of glucose homeostasis, has been scarcely investigated so far. On this basis, this study aimed to evaluate the effect of vitamin D supplementation in a murine model of diet-induced insulin resistance with particular attention to the effects evoked on the skeletal muscle. Male C57BL/6J mice (n = 40) were fed with a control or a High Fat-High Sugar (HFHS) diet for 4 months. Subsets of animals were treated for 2 months with vitamin D (7 μg·kg-1, i.p. three times/week). HFHS diet induced body weight increase, hyperglycemia and impaired glucose tolerance. HFHS animals showed an impaired insulin signaling and a marked fat accumulation in the skeletal muscle. Vitamin D reduced body weight and improved systemic glucose tolerance. In addition, vitamin D restored the impaired muscle insulin signaling and reverted myosteatosis evoked by the diet. These effects were associated to decreased activation of NF-κB and lower levels of TNF-alpha. Consistently, a significantly decreased activation of the SCAP/SREBP lipogenic pathway and lower levels of CML protein adducts and RAGE expression were observed in skeletal muscle of animals treated with vitamin D.Collectively, these data indicate that vitamin D-induced selective inhibition of signaling pathways (including NF-κB, SCAP/SREBP and CML/RAGE cascades) within the skeletal muscle significantly contributed to the beneficial effects of vitamin D supplementation against diet-induced metabolic derangements.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice

et al. 2018

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“…Ctrl group received standard rodent chow. DM group continued HFD, while Met group received HFD and treated orally with metformin for 4 weeks (Mostafa, Nasra, Zahran, & Ghoneim, ). Every DM + CV groups received HFD and treated orally with various dosage of CV for 4 weeks.…”

Section: Methodsmentioning

confidence: 99%

Coriolus versicolor aqueous extract ameliorates insulin resistance with PI3K/Akt and p38 MAPK signaling pathways involved in diabetic skeletal muscle

Xian

Che

Qin

et al. 2017

Phytotherapy Research

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Patients with type 2 diabetes mellitus (T2DM) are usually with poor immunity and easier to suffer from cancer and microbial infections. Herein, we report an efficient anti-diabetic medicinal mushroom, Coriolus versicolor (CV). This study aimed to investigate the anti-diabetic and anti-insulin-resistance effects of CV aqueous extract in myoblasts (L6 cells) and skeletal muscle of T2DM rat. Our results showed that CV extract treatment significantly reduced blood glucose levels of T2DM rats, whereas CV extract increased glucose consumption in insulin resistant L6 cells. Besides, the translocation and expression of glucose transporter 4 were enhanced by CV extract, which indicated that CV extract was effective in diabetic skeletal muscle. Moreover, CV extract treatments resulted in remarkable anti-insulin-resistance effects, which was reflected by the change of gene and protein expression levels in PI3K/Akt and p38 MAPK pathways. PI3K inhibitor, LY29004, and p38 MAPK inhibitor, SB203580 confirmed it further. In conclusion, our results demonstrated that the CV extract exhibited anti-diabetic and anti-insulin-resistance effects in diabetic skeletal muscle, and the effects were mediated by PI3K/Akt and p38 MAPK pathways. These findings are remarkable when considering the use of commercially available CV by diabetic patients who also suffer from cancer or microbial infections.

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“…In our current study, we evaluated serum insulin levels, vitamin D as well as vitamin D receptor. Results from preclinical studies showed that vitamin D (or calcitriol) administration reduced the levels of blood glucose and improved insulin sensitivity in diabetic mice [25] and attenuated the fibrosis [26]. activate insulin receptor and promote signaling pathway related to TGF-production and chemotaxis necessary for extracellular matrix synthesis.…”

Section: Elevated Frequencies Of Programmed Death Ligand 2 (Pdl2) In mentioning

confidence: 99%

Interleukin-4 retards liver fibrosis in BALB/c mice model of carbon tetra-chloride (CCl4)-associated with decreased CD80 and interleukin-12 expressions

Amer

Hattab

Rahal

2019

Preprint

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Background: BALB/c mice showed easily induced Th2-type responses in several infection models. Certain macrophage phenotypes contribute to liver fibrosis. We characterized changes in macrophages phenotype (M1/M2) during fibrogenesis in liver fibrosis mice model. Methods: Carbon-tetrachloride (CCl 4 ) hepatic-fibrosis was induced in BALB/c mice. Liver macrophages isolated were identified for M1 and M2 by CD80/iNOS and CD273 (programmed death ligand 2 (PDL2)/CD206, respectively. IL-4 were induced i.p along week-2 to week-4 of CCl 4 . Liver proteins were assessed for aSMA expressions, histology and ALT levels. Results: CCl 4 -induced hepatic-fibrosis showed increased CD273 (from 20.1%± 3.1in naïve mice to 27.8%±3.2 in fibrotic mice; P=0.01) while gradual decrease in CD80 (from 12%±6.2 in naïve mice to 1.97%±0.4 in fibrotic mice; P<0.02). The overall data showed decreased M1/M2 ratio. M2-macrophages showed inhibited expressions of IFN-g, IL-12 and vitamin-D-receptor (VDR) while high TGF-b levels. ALT, H&E staining intensities and aSMA showed gradually increased along fibrosis while metabolic markers of serum insulin, vitamin D and VDR decreased. IL-4 inductions while inhibited fibrosis it elevated metabolic markers. Conclusions: M2-macrophages express less IFN-g and IL-12, which might indicate inability differentiation of naive T cells into Th1 cells. IL-4 has an anti-fibrotic effects through antagonize M2-macrophages of TGF-b and ameliorating insulin, vitamin D, VDR and consequently attenuated liver-fibrosis.

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Pleiotropic protective effects of Vitamin D against high fat diet-induced metabolic syndrome in rats: One for all

Cited by 23 publications

References 49 publications

Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice

Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice

Coriolus versicolor aqueous extract ameliorates insulin resistance with PI3K/Akt and p38 MAPK signaling pathways involved in diabetic skeletal muscle

Interleukin-4 retards liver fibrosis in BALB/c mice model of carbon tetra-chloride (CCl4)-associated with decreased CD80 and interleukin-12 expressions

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