Pleomorphic acquired digital fibrokeratoma: A novel clinicopathologic entity

Wang, Leo; Abbott, Jeff; Jiang, Angela; Hannah, Claire; Rubin, Adam I.

doi:10.1111/cup.14320

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…13 Kint et al 14 classified ADF into three types based on the clinical and histopathological features: type I (many collagen fiber bundles accompanied by a large amount of capillary hyperplasia), type II (many collagen bundles accompanied by obvious keratinization of the epidermis), and type III (flat to domeshaped tumor with few cellular components). Leo L. Wang et al 15 reported a case which histopathology was consistent with an acquired digital fibrokeratoma with changes of a pleomorphic fibroma. Lesional cells were negative for CD34, Rb, and p53, and were positive for FXIIIa.…”

Section: Dovepressmentioning

confidence: 97%

Acquired Digital Fibrokeratoma: A Report of Five Cases and Review of the Literature

Wang,

Zhang,

Lin

et al. 2024

CCID

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Acquired digital fibrokeratoma (ADF) is rare in clinical practice and is easily misdiagnosed. Herein, 5 cases of patients (3 males and 2 females) with ADF are reported. The mean age at onset was 42.6 years, and the mean disease duration was 3 years. Four patients had ADF on the hands, and 1 patient had ADF on the foot. The clinical manifestations were all solitary, skin-colored papules, with a firm texture and smooth surface, protruding from the skin surface. In 3 patients, ADF manifested as columnar protrusions, and in 2 patients, ADF manifested as domeshaped protrusions. For all 5 patients, the diameters of the lesions were <1 cm. Clinically, all 5 patients were misdiagnosed (ie, eccrine poroma (EP), common warts, rudimentary polydactyly, pyogenic granuloma (PG), and acral fibroma). All cases of ADF were confirmed by histopathology. The histopathological manifestations of ADF were as follows: finger-like protrusions on the skin surface; collagen fiber bundles running vertically to the epidermis seen in the dermis; and thick red-stained collagen fibers connected with the normal dermal connective tissue below. All 5 patients underwent surgical resection; the distance between the incision margin and the edge of the tumor was 2-3 mm, and the surgical depth was the deep dermis. No recurrence was observed in more than half a year of follow-up after surgery.

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Section: Dovepressmentioning

confidence: 97%