Pleomorphic adenoma (benign mixed tumour) of the salivary glands: its diverse clinical, radiological, and histopathological presentation

Lingam, Ravi Kumar; Daghir, Ahmed A.; Nigar, E.; Abbas, Syeda A.B.; Kumar, Mahesh

doi:10.1016/j.bjoms.2009.09.014

Cited by 68 publications

(66 citation statements)

References 20 publications

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“…Its size at presentation varies considerably and depends on the duration of lesion [3]. Common age of presentation is 5th & 6th decade and has slight female predilection in contrast to the present case where the patient was male and quite younger, in his early 3rd decade of life.…”

Section: Discussioncontrasting

confidence: 71%

“…It most commonly presents in middle age and is common in women [3]. Pleomorphic adenoma occurs most commonly in the major salivary glands, 63% arising in the parotid gland [1], and most of these arise in the superficial lobe [3]. It appears as a firm, painless and slow growing mass that is commonly diagnosed long after the lesion has started [4].…”

Section: Discussionmentioning

confidence: 99%

“…Local recurrence after excision has been reported in 1-5% of cases [3]. Tumors with myxoid stroma demonstrate the highest incidence of capsular thinning or areas of capsular absence and pseudopodia formation [14] leading to increased propensity for recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…The parotid, submandibular glands, and the minor salivary glands of the palate are commonly involved, and the sublingual gland is rarely affected [1,2]. Pleomorphic adenoma occurs most commonly in the major salivary glands, 63% arising in the parotid gland [2], and most of these are seen in the superficial lobe [3]. Right side involvement is more common than left side and female to male ratio is 2:1.…”

Section: Introductionmentioning

confidence: 99%

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Pleomorphic Adenoma of Parotid in a Young Patient

Patankar¹,

Ma²,

Shewale³

et al. 2013

JCR

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Abstract:Salivary gland tumors are rare, comprising less than 3% of all neoplasia of head and neck region. Pleomorphic adenoma, is the most common salivary gland tumor, accounting for about 60% to 80% of the benign tumors of the salivary glands and for 60% to 70% of all the parotid tumors. Pleomorphic adenoma exhibits wide cytomorphologic and architectural diversity. It is found more commonly between fifth and sixth decades of life, female to male ratio being 2:1. Early diagnosis of this benign neoplasm is important as it has a high rate of recurrence and chances of malignant transformation. Due to few symptoms and the possibility of extension into a hidden site, such as the parapharyngeal space, the tumor can grow for a long time before being diagnosed, and the potential risk of malignant transformation increases over the years with an incidence of 1-7%. We present a case of pleomorphic adenoma diagnosed early in a young patient.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pleomorphic Adenoma of Parotid in a Young Patient

Patankar¹,

Ma²,

Shewale³

et al. 2013

JCR

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“…[1][2][3][4] Pleomorphic adenoma is most common in middle age and in women, 5 and although rare in children, it remains the most common solid parotid mass in the pediatric population. [6][7][8][9] These tumors arise directly from salivary gland tissue and consist of epithelial and mesenchymal cells; the latter can give rise to osseous, cartilaginous, hyaline, and myxoid elements, hence the name "mixed tumor."…”

Section: Discussionmentioning

confidence: 99%

Untitled

2012

J Neurol Surg Rep

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A 53-year-old man presented to the emergency department with a 7-day history of right ear fullness, otalgia, and hearing loss. He had recently been treated with antibiotics for sinusitis at an outside hospital but his symptoms failed to resolve. He denied vertigo, dizziness, otorrhea, or tinnitus. Physical examination demonstrated a mass behind an intact right eardrum, and tuning fork evidence of a conductive hearing loss. The remainder of his cranial nerve examination was normal, with the exception of the long-standing HouseBrackmann Grade VI/VI right facial nerve paralysis. Audiogram demonstrated a right moderate conductive hearing loss with flat (Type B) tympanogram. The left side was normal.The patient had a right parotid pleomorphic adenoma 35 years ago, which was treated by enucleation. He presented with several subcutaneous nodules 7 years after the initial treatment, which were treated by total parotidectomy. During surgery the facial nerve was sacrificed due to tumor encasement. Pathology confirmed recurrent pleomorphic adenoma. Postoperatively the tumor bed was treated with external beam radiotherapy. After this he remained asymptomatic for nearly 30 years.Magnetic resonance imaging of the head confirmed a large, irregular, heterogeneous, and variably enhancing mass in the right mastoid with extension medially along the floor of the posterior fossa measuring $5 Â 5 Â 5 cm (►Fig. 1). The mass eroded through the mastoid laterally and inferiorly into the upper cervical soft tissues. The superior portions of the mastoid were opacified with enhancement, suggesting tumor infiltration. The mass extended inferiorly into the parapharyngeal space and extrinsically compressed the right sigmoid sinus displacing it medially. In addition, a 1 Â 1 cm enhancing nodule in the right cerebellum medial to the cystic lesion was observed. The differential diagnosis at this point included carcinoma ex AbstractPleomorphic adenoma, also known as benign mixed tumor, is the most common tumor affecting the parotid gland and can reach massive size; however, intracranial invasion is rare. Recurrence of pleomorphic adenoma after excision is a well-known phenomenon and can present decades after resection of the primary tumor. Here we present the case of a 53-year-old man who presented to our clinic with ear fullness, otalgia, and hearing loss 30 years after undergoing total parotidectomy and external beam radiotherapy for pleomorphic adenoma. Magnetic resonance imaging revealed a massive transcranial tumor invading the mastoid cavity, the dura of the posterior fossa, the fallopian and semicircular canals, the jugular foramen, the lateral infratemporal fossa skull base, the sigmoid and transverse sinuses, and the superior parapharyngeal region. Gross examination and histopathological studies confirmed that the mass was a recurrent pleomorphic adenoma. Here we discuss the features of recurrent pleomorphic adenoma and review the current literature.

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