Pleomorphic adenoma of the human female breast

Agnantis, N.J.; Maounis, Nicoletta; Priovolou-Papaevangelou, Maria; Baltatzis, I.

doi:10.1016/s0344-0338(11)81190-8

Cited by 14 publications

(10 citation statements)

References 6 publications

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“…Although pleomorphic adenoma of the breast has been recognised for many years [1,3,4,5,7,12,19,23,25,26,30,36,46], as far as we are aware, its malignant counterpart has not been reported in the recent pathology literature. The recurrent pleomorphic adenoma of the breast reported by Soreide et al did not show histological features of malignancy [36].…”

Section: Discussionmentioning

confidence: 96%

Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type

Hayes

Lesack

Girardet³

et al. 2004

Virchows Arch

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Three cases of carcinoma ex-pleomorphic adenoma of the breast are reported. Patients were 82, 60 and 56 years old and presented with a breast lump. All tumours showed areas of pleomorphic adenoma adjacent to typical areas of malignant transformation. These cases add to the spectrum of tumours shared by breast and salivary gland. The relationship between these neoplasms and metaplastic carcinoma of matrix-producing type is discussed.

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Section: Discussionmentioning

confidence: 96%

Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type

Hayes

Lesack

Girardet³

et al. 2004

Virchows Arch

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“…1 The interest in many reports has focused on the histopathology of the tumor and the results of fi ne-needle aspiration. [1][2][3][4][5][6][7][8] Mammographic features were reported without [9][10][11][12] or with [13][14][15][16][17][18][19] images. The tumor is a well-circumscribed, round to ovoid mass, but sometimes shows an irregular shape with many protuberances.…”

Section: Introductionmentioning

confidence: 99%

Pleomorphic adenoma of the breast

et al. 2008

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Pleomorphic adenoma is a very rare benign tumor of the breast. Only 70 cases have been reported in the world literature. Recently, we encountered a case of pleomorphic adenoma of the breast and thus present here the mammographic and ultrasonographic findings with the pathology of this rare breast tumor. The patient was a 76-year-old Japanese woman with a right breast mass. The mammography showed a 1.5-cm, lobulated high-density mass with partially ill-defined margins. Ultrasonography revealed an irregularly shaped mass with partially ill defined borders, hypoechoic and heterogeneous internal echoes, and posterior acoustic enhancement. These findings suggested an invasive carcinoma. Awareness of this type of tumor will help in correct diagnosis, in spite of the rarity of this disease.

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“…6 PAB can also constitute a challenge at the time of intraoperative evaluation. In our review of the literature, we found that frozen section of PAB was obtained in six cases 10,17,20,[23][24][25] and an incorrect diagnosis of carcinoma was rendered in two, leading to modified radical mastectomy. 23,24 The cytologic diagnosis of PAB can be challenging because of the extreme rarity of this lesion in the breast and especially in cases with only suboptimal material (i.e., hypocellular smears, poor fixation, and lack of DiffQuik-stained material), available for review.…”

mentioning

confidence: 98%

“…In our review of the literature, we found that frozen section of PAB was obtained in six cases 10,17,20,[23][24][25] and an incorrect diagnosis of carcinoma was rendered in two, leading to modified radical mastectomy. 23,24 The cytologic diagnosis of PAB can be challenging because of the extreme rarity of this lesion in the breast and especially in cases with only suboptimal material (i.e., hypocellular smears, poor fixation, and lack of DiffQuik-stained material), available for review. The quality of the background stroma, the bland cytomorphology of PAB, along with the paucity of mitoses and absence of tumor necrosis, should be of guidance in the evaluation of frozen sections and FNA material from PAB.…”

mentioning

confidence: 98%

“…These findings may trigger a malignant diagnosis, especially if only limited sampling is available for review, such as frozen section or fineneedle aspiration (FNA) material. 1,[3][4][5]17,20,[23][24][25] The differential diagnosis of PAB includes aggressive lesions such as metaplastic carcinoma and phyllodes tumor.We report a case of PAB misdiagnosed as mucinous carcinoma on FNA material and discuss the cytologic and histologic findings of this lesion, with special emphasis on its differential diagnosis, and review of the literature. …”

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confidence: 99%

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Pleomorphic adenoma of the breast: Case report and review of the literature

Iyengar

Cody

2005

Diagn. Cytopathol.

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Pleomorphic adenoma of the breast (PAB) is a very rare neoplasm. Although quite unique in its morphology, PAB shares some similarities with adenomyoepithelioma and is considered by some authors as a variant of this entity. Cytologic diagnosis of this lesion can be very challenging, especially when limited sampling is available. The differential diagnosis of PAB includes metaplastic carcinoma. On cytologic material, fibroadenoma and phyllodes tumor should also be considered within the differential diagnosis. We report the findings in a case of PAB, initially misdiagnosed as mucinous carcinoma on fine-needle aspiration, and review the literature regarding this entity. Correct identification of this benign mammary neoplasm is important to avoid unnecessarily aggressive treatment.

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Pleomorphic adenoma of the human female breast

Cited by 14 publications

References 6 publications

Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type

Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type

Pleomorphic adenoma of the breast

Pleomorphic adenoma of the breast: Case report and review of the literature

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