Pleomorphic adenoma of the maxillary sinus with orbital extension presenting with exophthalmos: a case report

Lygeros, Spyridon; Tsapardoni, Foteini; Mastronikolis, Stylianos; Axioti, Anna-Maria; Grypari, Ioanna-Maria; Danielides, Gerasimos; Naxakis, S

doi:10.21037/acr-21-31

Cited by 2 publications

(9 citation statements)

References 10 publications

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“…Incomplete data obtained from listing a 49-year-old woman as one of the 17 cases of the series by Li et al prevented an analysis of the tumor origin [22]. The cases presented by Lygeros et al and Ray et al seem to be the only ones in which tumor emergence from the mouth or nose was not indicated [21,24]. PA in the report by Ray et al differs additionally in the histological picture due to the presence of calcifications [24].…”

Section: Results Of Individual Studies and Synthesismentioning

confidence: 98%

“…The follow-up time after the surgical removal of MSPA followed by the first recurrence, was 2, 6, and 14 years according to three of the studies eligible for this synthesis [23,25,26]. Authors who did not report a recurrence after treatment decided to follow up at 8 months, 1 year, 3 years and 4 years before the publication of their cases, that is, on average, 2 years and 2 months [21,22,24,27]. The size of the detected MSPA in the largest dimension ranged in various cases from 40 to 60 mm, with an average of 48 mm [22][23][24][25].…”

Section: Results Of Individual Studies and Synthesismentioning

confidence: 99%

“…The extremely small amount of data prevented further processing. An extremely small number of reports were identified, as only seven described cases of PA originally localized in MS [21][22][23][24][25][26][27]. It is known that PA may originate from the oral mucosa glands and approach the maxillary sinus from the palate side [16,23].…”

Section: Results Of Individual Studies and Synthesismentioning

confidence: 99%

“…Likewise, nasal PA also develops adjacently to the maxillary sinus [17,28,29]. Therefore, it cannot be guaranteed for any of the included case reviews that PA actually originated from the mucosa of the maxillary sinus [21][22][23][24][25][26][27]. In the report by Ishikawa et al, the tumor entered the maxillary sinus presumably from the nasal cavity [27].…”

Section: Results Of Individual Studies and Synthesismentioning

confidence: 99%

“…The dominant symptoms in the form of swelling of the cheek, palate or lateral wall of the nose can be easily explained by the expanding growth of PA [1,4]. Computed tomography was the only test that confirmed the presence of PA in the sinus and provided information on the extent and nature of the tumor [21,[23][24][25]27]. Therefore, it should be considered a standard diagnostic tool when MSPA is suspected.…”

Section: Diagnostics and Treatmentmentioning

confidence: 99%

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Maxillary Sinus Pleomorphic Adenoma: A Systematic Review

Chęciński¹,

Nowak

2022

Surgeries

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Background: Pleomorphic adenoma (PA), also known as a mixed tumor, is a neoplasm of the glandular tissue. The maxillary sinus (MS) is an atypical location of PA; however, as an empty cavity inside the bone, it predisposes tumors to develop unnoticed. The aim of the following systematic review was to identify and characterize the diagnostics and prognosis of maxillary sinus pleomorphic adenoma (MSPA). Methods: The cases of MSPA that underwent treatment and were observed for possible recurrence were qualified for the review. The medical databases were searched using the following engines: ACM, BASE, Google Scholar and PubMed. The risk of bias was assessed using the JBI Critical Appraisal Tool for Case Reports. The extracted data were tabulated and summarized in a descriptive manner. Results: To the best knowledge of the authors, only seven cases of MSPA were described in the last 20 years. Relapse occurred in three of these cases and malignant transformation occurred in two. The longest recorded time without recurrence was 4 years. The size of the detected MSPA in the largest dimension ranged in various cases from 40 to 60 mm, with an average of 48 mm. Discussion: All but one of the seven included reports showed flaws during the risk of bias assessment. Only in two of seven reported cases was there no reason to suspect that the tumor had penetrated the sinus from the oral or nasal cavity. The MS is disadvantageous as a location as tumors occupying the entire volume of the sinus are often diagnosed. Recurrences and malignant transformations seem to be frequent and often remain undetected for a prolonged period. Other information: This research received no external funding. OSF Registries number: 8KVGM.

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Section: Results Of Individual Studies and Synthesismentioning

confidence: 98%

Section: Results Of Individual Studies and Synthesismentioning

confidence: 99%

Section: Results Of Individual Studies and Synthesismentioning

confidence: 99%

Section: Results Of Individual Studies and Synthesismentioning

confidence: 99%

Section: Diagnostics and Treatmentmentioning

confidence: 99%

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Maxillary Sinus Pleomorphic Adenoma: A Systematic Review

Chęciński¹,

Nowak

2022

Surgeries

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A Review of the Current Literature on Pleomorphic Adenoma

Kalwaniya¹,

Meena²,

Kumar³

et al. 2023

Cureus

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Pleomorphic adenomas (PA) are the most common benign salivary gland tumors. They arise from the major salivary glands, as well as the minor salivary glands. They may arise rarely from the palate, oral cavity, neck, and nasal cavity also. Yet, the fourth, fifth, and sixth decades of life are the most common for them to manifest. Forty percent of them occur in males and 60% in females. It is a benign mixed tumor, which has three components: an epithelial component, a myoepithelial cell component, and a mesenchymal component. A fibrous capsule separates these cells from the surrounding tissues. It generally presents as a slowly progressing painless swelling, which is well-delineated, nonsymptomatic, and not involving the facial nerve. Salivary gland tumors can be accurately diagnosed before surgery using fine-needle aspiration (FNA), ultrasonography (USG), and computed tomography (CT) scan. Calponin, cluster of differentiation 9 (CD9), glial fibrillary acidic protein (GFAP), Mcl-2, metastasis suppressor gene (NM23), p63, S-100, smooth muscle actin (SMA), and SRY-box transcription factor 10 (SOX10) exhibit the majority of the positive reactions in pleomorphic adenomas. The diagnostic marker pleomorphic adenoma gene 1 (PLAG1) is frequently employed since it is specific for pleomorphic adenoma. Although benign, these epithelial tumors have a propensity to recur and undergo malignant transformation if incompletely excised, leading to increased morbidity in these patients. A review of the consensus guidelines and literature was conducted, and the online literature on the subject from 2002 was included. This article is not a complete review of all the available literature; rather, it is a comprehensive review of the topic.

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Pleomorphic adenoma of the maxillary sinus with orbital extension presenting with exophthalmos: a case report

Cited by 2 publications

References 10 publications

Maxillary Sinus Pleomorphic Adenoma: A Systematic Review

Maxillary Sinus Pleomorphic Adenoma: A Systematic Review

A Review of the Current Literature on Pleomorphic Adenoma

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