Pleomorphic lobular carcinoma of the breast: a non-evident diagnosis: case report and reviewof the literature

Background Trichoblastic carcinoma (or malignant trichoblastoma) is a rare malignant cancer of adnexal structures with morphological features that in some cases are reminiscent of a trichoblastoma. Trichoblastic carcinoma is underdiagnosed as it is a rather recent entity which is still not recognized as such by all pathologists. The differential diagnosis with basal cell carcinoma is often difficult to make and the optimal treatment has not yet been established. Case report We report the case of a 43-year-old patient who underwent surgical excision and adjuvant radiotherapy for a growing mass of 40 × 48 mm located in the lumbar right paraspinal skin. The pathological findings demonstrated a trichoblastic carcinoma. The clinicopathological profile, the histogenesis, and the difficulties related to the histopathological diagnosis and treatment of this rare entity are discussed in this article. Conclusion Although the published reports on this disease are few, surgery should be considered the standard therapeutic approach for trichoblastic carcinomas. Selected cases presenting clinical features of local aggressiveness can safely be treated with adjuvant irradiation to improve local control. However, acute and particularly late toxicities need to be taken into account in the decision.

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Histological Features and Treatment Approach of Trichoblastic Carcinomas: From a Case Report to a Review of the Literature

Laffay

Depaepe

d’Hombres

et al. 2012

Tumori

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Pleomorphic lobular carcinoma of the breast: a non-evident diagnosis: case report and reviewof the literature

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Histological Features and Treatment Approach of Trichoblastic Carcinomas: From a Case Report to a Review of the Literature

Histological Features and Treatment Approach of Trichoblastic Carcinomas: From a Case Report to a Review of the Literature

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