Pleural cancer antigen-125 levels in benign and malignant pleural effusions

Wi, Choi; Qama, Diana; Lee, MY; Ky, Kwon

doi:10.5588/ijtld.12.0635

Cited by 7 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Choi et al . 23 found that pleural CA-125 levels were significantly higher in malignant pleural effusions than those in benign pleural effusions. Bielsa et al .…”

Section: Discussionmentioning

confidence: 87%

The risk factors of bone metastases in patients with lung cancer

Zhou

Peng

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The risk factors of bone metastasis in patients with lung cancer are still unclear. Here, a retrospective study including a series of consecutive patients who were diagnosed with lung cancer between January 2005 and November 2016 was carried out. A total of 2021 patients with lung cancer were included in this study and 23.9% of them were found to be bone metastases. For patients with bone metastases, adenocarcinoma (62.1%) was the most common pathological subtype, and rib (62.3%) was the most frequent distant metastatic site, followed by thoracic (53.8%) and lumbar spine (40.4%). The histopathologic type, CA-125 level and the concentration of alkaline phosphatase (ALP) were identified as the independent risk factors for bone metastases in lung cancer (P = 0.002, P = 0.001 and P < 0.001). The sensitivities and specificities of diagnosing bone metastasis by CA-125 were 32.1% and 80.8%, and by ALP were 41.3% and 77.1%, respectively. Thus, the incidence of bone metastases in lung cancer patients was relative high, and physicians should pay attention to the histopathologic type, the serum CA-125 and ALP concentrations when patients were firstly diagnosed with lung cancer for early detecting bone metastases.

show abstract

“…Choi et al . 23 found that pleural CA-125 levels were significantly higher in malignant pleural effusions than those in benign pleural effusions. Bielsa et al .…”

Section: Discussionmentioning

confidence: 87%

The risk factors of bone metastases in patients with lung cancer

Zhou

Peng

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…By way of a solution to these problems, measuring the concentration of various tumor markers (TMs) in PE is a useful and noninvasive procedure for distinguishing between benign PE and MPE. [ 5 6 7 ] The TMs concerned are carbohydrate antigen 125 (CA125), carbohydrate antigen 153, carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA), cytokeratin 19 fragment, neuron-specific enolase (NSE), and squamous cell carcinoma (SCC) associated antigen. However, their cut-off values and sensitivities in identifying MPE are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Clinical Value of Tumor Markers for Determining Cause of Pleural Effusion

Zhai²,

Shi

2016

Chinese Medical Journal

View full text Add to dashboard Cite

Background:It is often challenging to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE); thoracoscopy is among the techniques with the highest diagnostic ability in this regard. However, such invasive examinations cannot be performed on the elderly, or on those in poor physical condition. The aim of this study was to explore the differential diagnostic value of carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and squamous cell carcinoma (SCC) associated antigen in patients with TPE and MPE.Methods:Using electrochemiluminescence, we measured the concentration of tumor markers (TMs) in the pleural effusion and serum of patients with TPE (n = 35) and MPE (n = 95). We used receiver operating characteristic (ROC) curve analysis to evaluate the TMs and differentiate between TPE and MPE.Results:The cut-off values for each TM in serum were: CA125, 151.55 U/ml; CA199, 9.88 U/ml; CEA, 3.50 ng/ml; NSE, 13.27 ng/ml; and SCC, 0.85 ng/ml. Those in pleural fluid were: CA125, 644.30 U/ml; CA199, 12.08 U/ml; CEA, 3.35 ng/ml; NSE, 9.71 ng/ml; and SCC, 1.35 ng/ml. The cut-off values for the ratio of pleural fluid concentration to serum concentration (P/S ratio) of each TM were: CA125, 5.93; CA199, 0.80; CEA, 1.47; NSE, 0.76; and SCC, 0.90. The P/S ratio showed the highest specificity in the case of CEA (97.14%). ROC curve analysis revealed that, for all TMs, the area under the curve in pleural fluid (0.95) was significantly different from that in serum (0.85; P < 0.001).Conclusions:TMs in TPE differ significantly from those in MPE, especially when detected in pleural fluid. The combined detection of TMs can improve diagnostic sensitivity.

show abstract

“…in the pleural fluid did significantly differ (p < 0.001) Choi et al (2013). determined Ca-125 levels in pleural puncture fluid of 326 patients and afterwards retrospectively analysed its level in patients with various aetiology of the pleural fluid.…”

mentioning

confidence: 99%

Diagnostic value of tumour markers Ca-125 and CEA in the diagnostics of malignant pleural fluids

Žentiņa

Stukena

Grīnberga

et al. 2016

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

View full text Add to dashboard Cite

The significance of carbohydrate (cancer) antigen 125 and carcinoembryonic antigen (CEA) tumour markers levels in differential diagnostics of malignant and benign pleural effusion was studied. Within this prospective study, 121 patients with fluids of various aetiology in the pleural cavity were analysed. Malignant pleural effusion was detected in 55 patients, parapneumonic effusion in 28 patients, transudative effusion of cardiac origin in 31 patients, pancreatitis in one patient and tuberculous pleurisy in five patients. The highest accuracy in diagnosis of malignancy was observed for Ca-125 and CEA levels in the pleural fluid: 75.2% at cut-off value ³ 1452 U/mL and 76.9% at cut-off value ³ 6.58 ng/mL, respectively. We conclude that the level of tumour markers in pleural fluid has additional diagnostic significance in the differential diagnosis of malignant and benign pleural effusions.

show abstract

Pleural cancer antigen-125 levels in benign and malignant pleural effusions

Cited by 7 publications

References 0 publications

The risk factors of bone metastases in patients with lung cancer

The risk factors of bone metastases in patients with lung cancer

Clinical Value of Tumor Markers for Determining Cause of Pleural Effusion

Diagnostic value of tumour markers Ca-125 and CEA in the diagnostics of malignant pleural fluids

Contact Info

Product

Resources

About