Pleural Mesothelioma with No  Asbestos Exposure: A Case Report

Batahar, S. Àit; Ouradi, Othmane; Elidrissi, Safae; Àmro, L.

doi:10.7860/jcdr/2016/21066.8849

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…The latency period between asbestos exposure and MPM onset ranges from 20 to 40 years, 6 with patients typically presenting after the age of 50 years, and death occurring at around the age of 70 years. 7 Consistent with historical patterns of occupational exposure, males tend to be affected more frequently (male-to-female ratio of approximately 3-4:1).…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of MPM is confirmed by cytology in only 20% to 30% of cases, and by percutaneous pleural biopsy in 20% to 23% of cases. 6 While thoracentesis is rarely diagnostic, high levels of hyaluronic acid in the pleural fluid are highly suggestive of MPM and, if present, are associated with a good prognosis. 8 Image-guided core and surgical biopsies demonstrate much higher sensitivities of 86% and 94% to -100% respectively.…”

Section: Discussionmentioning

confidence: 99%

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An Unexpected Case of Malignant Mesothelioma in a Young Woman

Dhamrah

Solomon

Osuoji

2021

Journal of Investigative Medicine High Impact Case Reports

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A 41-year-old female with a past medical history significant only for right retinal vein occlusion presented with chest pain, cough, and shortness of breath. After being found to have a large right-sided pleural effusion and undergoing a nondiagnostic thoracentesis, a noncontrast chest computed tomography scan revealed multiple diffuse nodules in the right lung with irregular paraspinal pleural thickening. An extensive workup followed, with computed tomography–guided biopsy ultimately revealing the diagnosis. The following report describes the patient presentation, laboratory findings, and extensive clinical investigation, and provides a discussion of the epidemiology, imaging findings, prognosis, and differential diagnoses for the illness in question.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An Unexpected Case of Malignant Mesothelioma in a Young Woman

Dhamrah

Solomon

Osuoji

2021

Journal of Investigative Medicine High Impact Case Reports

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“…Although mesothelioma is strongly associated with asbestos exposure, approximately 20% of patients with mesothelioma have no demonstrable asbestos exposure, even after a detailed assessment ( 23 - 26 ). It has been reported that other mineral fibers, such as erionite, nanotubes, and irradiation are possible risk factors for the development of mesothelioma ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Malignant Pleural Mesothelioma with Bone Marrow Metastases

et al. 2018

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A 64-year-old man with the bone marrow metastasis due to malignant pleural mesothelioma (MPM) was diagnosed with anemia, leukoerythroblastosis, thrombocytopenia, and lower back pain. A bone marrow biopsy demonstrated infiltrative malignant mesothelioma lesions in the bone marrow. The patient died within 15 days of the detection of the bone marrow involvement. Physicians should consider performing a bone marrow biopsy to diagnose bone marrow metastasis and treat patients with palliative chemotherapy at an earlier phase of the disease. To our knowledge, this is the first report of an MPM patient having bone marrow metastasis with anemia, leukoerythroblastosis, and thrombocytopenia.

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“…Usually, in pericardial involvement, direct tumor invasion is associated [10]. The most typical presentation is a recurrent unilateral pleural effusion which is sometimes exudative and hemorrhagic [5,6]. Parietal pleura involvement is more common than visceral pleura.…”

Section: Pathological Findingsmentioning

confidence: 99%

“…The most typical presentation is recurrent unilateral pleural effusion and, pericardial involvement is uncommon. On top of that, it is rare to find peripheral extrathoracic lymphadenopathy or distant metastasis before the primary tumor [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

Mesothelial Cells in Lymph Nodes Associated with Massive Pericardial and Bilateral Pleural Effusion, a Diagnostic Dilemma: Report of a Case

Mohammadali¹,

Ghorbanpour²,

Narges³

2020

Clin Med Rev Case Rep

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Malignant pleural mesothelioma is a rare neoplasm that mostly occurs in elderly men. Recurrent unilateral pleural effusion is the most typical presentation and it is very rare to find extra-thoracic lymphadenopathy before the primary tumor, even in advanced cases. Herein, we report a challenging case of a young man presenting with unresolved fever, sore throat, and dysphagia associated with massive pleural effusion, cardiac tamponade, and multiple cervical lymphadenopathy with mesothelial cells infiltration. Microscopic examination of lymph node structures revealed reactive follicular architecture and massive infiltration of epithelioid cells with pleomorphic vesicular nuclei in the sinuses and subcapsular spaces. Immunohistochemical staining of the epithelioid cells demonstrated a positive reaction to PAN-Cytokeratin (CK), CK7, calretinin, Wilms tumor (WT1), and CK5/6 while Ki-67 labeling index showed low proliferative activity. Biopsy of pericardium and fluid cytology revealed no evidence of malignancy. The patient underwent a second surgery due to unresolved effusion. Sample taken from the anterior mediastinal area showed infiltrating tubulo-glandular proliferation spreading to mediastinal fat component. Thereafter, the diagnosis of malignant mesothelioma originating from mediastinal reflections of the pleura was established. It is very important for the pathologist to accurately diagnose malignant mesothelioma over other differential diagnoses to prevent misdiagnosis in such rare and complicated cases.

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Pleural Mesothelioma with No Asbestos Exposure: A Case Report

Cited by 3 publications

References 5 publications

An Unexpected Case of Malignant Mesothelioma in a Young Woman

An Unexpected Case of Malignant Mesothelioma in a Young Woman

Malignant Pleural Mesothelioma with Bone Marrow Metastases

Mesothelial Cells in Lymph Nodes Associated with Massive Pericardial and Bilateral Pleural Effusion, a Diagnostic Dilemma: Report of a Case

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