Pleural mesotheliomas in Sprague-Dawley rats by erionite: First experimental evidence

Maltoni, Cesare; Minardi, Franco; Morisi, L.

doi:10.1016/0013-9351(82)90024-x

Cited by 49 publications

(21 citation statements)

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“…These results reaffirm the sensitivity of the A L cell system for identifying mutagens that induce predominately multilocus deletions, including radon α particles (Evans, 1993;Zhu et al, 1996;Hei et al, 1997) and arsenic (Hei et al, 1998). The strong mutagenic potential of erionite, as demonstrated in this report, is consistent with its carcinogenic effects demonstrated in both epidemiological and animal studies (Maltoni et al, 1982;Rohl et al, 1982;Johnson et al, 1984;Wagner et al, 1985). Although the carcinogenic mechanism of erionite is not clear, there is evidence to suggest that its ability to induce hydroxyl radicals may be critical to its genotoxic effects in vitro (Maples and Johnson, 1992).…”

Section: Discussionsupporting

confidence: 75%

“…Although tremolite was reported to be a strong inducer of micronuclei and a weak inducer of chromosomal aberrations in mammalian cells, it was non-active as a gene mutagen when tested using the bacterial Salmonella typhimurium assay (Athanasiou, 1992). Similarly, erionite, a fibrous zeolite with physical characteristics comparable to those of crocidolite, has been shown to be associated with pleural diseases, including mesothelioma, in Turkey (Rohl et al, 1982;Baris et al, 1987) and its high (probably the highest among various fibres) carcinogenic property has been proven in various in vivo and in vitro experiments (Maltoni et al, 1982;Johnson et al 1984;Wagner et al, 1985). A more pronounced cytogenetic effect of erionite in V79 cells as compared to either chrysotile or crocidolite fibres has been documented (Palekar et al, 1987).…”

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confidence: 99%

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Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells

Okayasu

Hei

1999

Br J Cancer

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Cytotoxicity and mutagenicity of tremolite, erionite and the man-made ceramic (RCF-1) fibre were studied using the human– hamster hybrid A L cells. Results from these fibres were compared with those of UICC Rhodesian chrysotile fibres. The A L cell mutation assay, based on the S1 gene marker located on human chromosome 11, the only human chromosome contained in the hybrid cell, has been shown to be more sensitive than conventional assays in detecting deletion mutations. Tremolite, erionite and RCF-1 fibres were significantly less cytotoxic to A L cells than chrysotile. Mutagenesis studies at the HPRT locus revealed no significant mutant yield with any of these fibres. In contrast, both erionite and tremolite induced dose-dependent S1 − mutations in fibre-exposed cells, with the former inducing a significantly higher mutant yield than the latter fibre type. On the other hand, RCF-1 fibres were largely non-mutagenic. At equitoxic doses (cell survival at ∼ 0.7), erionite was found to be the most potent mutagen among the three fibres tested and at a level comparable to that of chrysotile fibres. These results indicate that RCF-1 fibres are non-genotoxic under the conditions used in the studies and suggest that the high mesothelioma incidence previously observed in hamster may either be a result of selective sensitivity of hamster pleura to fibre-induced chronic irritation or as a result of prolonged fibre treatment. Furthermore, the relatively high mutagenic potential for erionite is consistent with its documented carcinogenicity. © 1999 Cancer Research Campaign

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Section: Discussionsupporting

confidence: 75%

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confidence: 99%

Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells

Okayasu

Hei

1999

Br J Cancer

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“…In another case of potential environmental zeolite exposure, Casey et al (1981) treated a patient with extensive parenchymal and pleural brosis who resided and worked in an area rich in zeolite deposits. A similarly brous zeolite, erionite, has been shown to produce pleural tumors in rats (Wagner et al 1985;Johnson et al 1984;Maltoni et al 1982;and Suzuki 1982).…”

Section: Introductionmentioning

confidence: 99%

A Fiber Characterization of the Natural Zeolite, Mordenite: A Potential Inhalation Health Hazard

Stephenson¹,

Fairchild²,

Buchan³

et al. 1999

Aerosol Science and Technology

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ABSTRACT. Interest in mordenite as an inhalation hazard arose when it was discovered that the mineral exists in the subsurface of Yucca Mountain, NV, the site of a federally proposed nuclear waste repository. During preliminary geologic investigations at Yucca Mountain, workers performing air coring (dry-drilling) operations were potentially exposed to aerosols of mordenite. Mordenite is also increasingly used in industrial applications, such as cation exchange, molecular absorbency, and reversible dehydration. Concern that the brous nature of mordenite may present an inhalation hazard is supported by the "Stanton Hypothesis," which states that the carcinogenicity of any ber type depends upon dimension and durability rather than physicochemical properties. To date, little scienti c literature is available on the inhalation health hazards of mordenite. This study initiates research in this area.Mordenite specimens collected from different geologic localities were analyzed macroscopically and microscopically. Mineral veri cation was performed using energy dispersive x-ray and x-ray diffraction analysis. Fibrous aerosols were generated to simulate aerosols created during air coring operations. Anderson cascade impactors were used to obtain aerosol mass median aerodynamic diameters. Electron microscopy of nucleopore lters allowed for individual aerosol bers to be morphologically sized and applied to the Stanton Hypothesis for mesothelioma induction. Physical ber dimensions were used to calculate aerodynamic diameters and to estimate pulmonary deposition. Results obtained from this study indicate that under similar conditions of aerosolization, using similar mordenite materials, inhalation of mordenite bers could produce substantial deep-lung deposition. 468 D. J. Stephenson et al.

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“…3 Very little is known about the hazards associated with dusts containing fibrous zeolites, especially mordenite, but limited animal toxicology studies performed with erionite indicate that it may have far greater potential for causing lung tumors, including malignant mesothelioma, than does asbestos (causing almost 100% tumor incidence in rats, compared with about 20% for asbestos). 4 …”

Section: Task 4 -Recommendations For Exploratory Shaft Facility At Yumentioning

confidence: 99%

Evaluation of dust-related health hazards associated with air coring at G-Tunnel, Nevada Test Site

Skaggs¹,

Ortiz²,

Burton³

et al. 1991

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Pleural mesotheliomas in Sprague-Dawley rats by erionite: First experimental evidence

Cited by 49 publications

References 1 publication

Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells

Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells

A Fiber Characterization of the Natural Zeolite, Mordenite: A Potential Inhalation Health Hazard

Evaluation of dust-related health hazards associated with air coring at G-Tunnel, Nevada Test Site

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