Pleural space infection microbiology as assessed using a clinical sequencing-based assay:
Fusobacterium nucleatum
group,
Streptococcus intermedius,
and other oral normal microbiota are the most common bacteria identified in community-acquired pleural space infections
Judith Alvarez Otero,
Jay Mandrekar,
Matt J. Wolf
et al.
Abstract:The definition of the microbiology of pleural space infection has been challenging due to the poor yield of conventional culture. Here, the results of a 16S ribosomal RNA gene PCR/sequencing assay performed on pleural fluid in routine clinical practice between August 2020 and January 2023 were evaluated. Amplified 16S rRNA gene DNA was submitted to Sanger sequencing and/or next-generation sequencing or results were reported as negative, depending on PCR crossing threshold value. In all, 496 pleural fluids were… Show more
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