Pleurectomy for mesothelioma

Extrapleural pneumonectomy for malignant pleural mesothelioma: Outcomes of treatment and prognostic factors

“…Extrapleural pneumonectomy (EPP) is en bloc resection of the disease involving the pleurae, lung, ipsilateral hemidiaphragm, and pericardium. [1][2][3][4][5][6] It has been used as a treatment option for selected patients with malignant pleural mesothelioma (MPM). 1,3,5,6 Recent evidence has suggested that EPP in conjunction with chemotherapy and radiotherapy may improve local disease control and survival, when compared with historical data.…”

Radical pleurectomy/decortication and intraoperative radiotherapy followed by conformal radiation with or without chemotherapy for malignant pleural mesothelioma

“…Although this approach is technically difficult, it is generally less morbid and better tolerated than EPP, with perioperative mortality rates of less than 5%. [6][7][8] As a single modality, the results of aggressive surgical resections have been disappointing, with median survivals of less than 1 year in most series. 3,4,6,7 Radiation therapy has also been used for the treatment of DMPM.…”

“…[6][7][8] As a single modality, the results of aggressive surgical resections have been disappointing, with median survivals of less than 1 year in most series. 3,4,6,7 Radiation therapy has also been used for the treatment of DMPM. However, the results of radiation therapy alone have been disappointing and generally used for palliation.…”

Surgical Treatment of Mesothelioma: Pleurectomy

“…Brancatisano et al 9 summarized results of 50 patients surgically treated at the Concord and Royal Prince Alfred Hospital, 45 of whom underwent pleurectomy. One patient died from the surgery, for a perioperative mortality of 2.2%; surgery-related morbidity was 16%.…”