Pleuritis and suppurative pneumonia associated with a hypermucoviscosity phenotype of Klebsiella pneumoniae in California sea lions (Zalophus californianus)

Jang, Spencer S.; Wheeler, Liz; Carey, Roberta B.; Jensen, Bette; Crandall, Claudia; Schrader, Kimmi N.; Jessup, David A.; Colegrove, Kathleen M.; Gulland, Frances M. D.

doi:10.1016/j.vetmic.2009.07.032

Cited by 46 publications

(43 citation statements)

References 13 publications

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“…Multisystemic abscesses in African Green Monkeys ( Chlorocebus aethiops ) caused by the K. pneumoniae K2 serotype was reported in animals kept in captivity in the United States . In addition, K2‐associated genes ( wzy ), positive for rmpA and negative for magA, have reported as the etiologic agent of suppurative pneumonia, pleuritis, and abscesses in California sea lions ( Zalophus californianus ) . Therefore, it is important to determine the origin of an infection, particularly for improving the management of these outbreaks in NHPs …”

Section: Discussionmentioning

confidence: 99%

First case report of non‐human primates (Alouatta clamitans) with the hypervirulent Klebsiella pneumoniae serotype K1 strain ST 23: A possible emerging wildlife pathogen

Anzai

Júnior

Peruchi

et al. 2017

J of Medical Primatology

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Section: Discussionmentioning

confidence: 99%

First case report of non‐human primates (Alouatta clamitans) with the hypervirulent Klebsiella pneumoniae serotype K1 strain ST 23: A possible emerging wildlife pathogen

Anzai

Júnior

Peruchi

et al. 2017

J of Medical Primatology

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“…1073/pnas.1501049112/-/DCSupplemental. K. pneumoniae, particularly when hypermucoid, can cause invasive disease in several animal species (8,9) and is a common cause of mastitis in dairy herds (10). Moreover it can thrive in a range of plant hosts and environmental niches, including water, soil, and plant matter (4,5,11).…”

Section: Significancementioning

confidence: 99%

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health

Holt

Wertheim

Zadoks

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

1,040

1,123

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Klebsiella pneumoniae is now recognized as an urgent threat to human health because of the emergence of multidrug-resistant strains associated with hospital outbreaks and hypervirulent strains associated with severe community-acquired infections. K. pneumoniae is ubiquitous in the environment and can colonize and infect both plants and animals. However, little is known about the population structure of K. pneumoniae, so it is difficult to recognize or understand the emergence of clinically important clones within this highly genetically diverse species. Here we present a detailed genomic framework for K. pneumoniae based on whole-genome sequencing of more than 300 human and animal isolates spanning four continents. Our data provide genome-wide support for the splitting of K. pneumoniae into three distinct species, KpI (K. pneumoniae), KpII (K. quasipneumoniae), and KpIII (K. variicola). Further, for K. pneumoniae (KpI), the entity most frequently associated with human infection, we show the existence of >150 deeply branching lineages including numerous multidrug-resistant or hypervirulent clones. We show K. pneumoniae has a large accessory genome approaching 30,000 protein-coding genes, including a number of virulence functions that are significantly associated with invasive community-acquired disease in humans. In our dataset, antimicrobial resistance genes were common among human carriage isolates and hospital-acquired infections, which generally lacked the genes associated with invasive disease. The convergence of virulence and resistance genes potentially could lead to the emergence of untreatable invasive K. pneumoniae infections; our data provide the whole-genome framework against which to track the emergence of such threats.

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“…K. pneumoniae can be transferred through medical equipment and blood products (6, 7) and can be carried within the intestinal tracts of patients and on the skin surface of hospital personnel (3, 8, 9). K. pneumoniae can also cause invasive disease in various animal species (10, 11), and animal and food sources have been proposed to serve as potential reservoirs for K. pneumoniae (12). …”

Section: Introductionmentioning

confidence: 99%

Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland

Moradigaravand

Martin

Peacock

et al. 2017

mBio

115

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Klebsiella pneumoniae is a human commensal and opportunistic pathogen that has become a leading causative agent of hospital-based infections over the past few decades. The emergence and global expansion of hypervirulent and multidrug-resistant (MDR) clones of K. pneumoniae have been increasingly reported in community-acquired and nosocomial infections. Despite this, the population genomics and epidemiology of MDR K. pneumoniae at the national level are still poorly understood. To obtain insights into these, we analyzed a systematic large-scale collection of invasive MDR K. pneumoniae isolates from hospitals across the United Kingdom and Ireland. Using whole-genome phylogenetic analysis, we placed these in the context of previously sequenced K. pneumoniae populations from geographically diverse countries and identified their virulence and drug resistance determinants. Our results demonstrate that United Kingdom and Ireland MDR isolates are a highly diverse population drawn from across the global phylogenetic tree of K. pneumoniae and represent multiple recent international introductions that are mainly from Europe but in some cases from more distant countries. In addition, we identified novel genetic determinants underlying resistance to beta-lactams, gentamicin, ciprofloxacin, and tetracyclines, indicating that both increased virulence and resistance have emerged independently multiple times throughout the population. Our data show that MDR K. pneumoniae isolates in the United Kingdom and Ireland have multiple distinct origins and appear to be part of a globally circulating K. pneumoniae population.

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Pleuritis and suppurative pneumonia associated with a hypermucoviscosity phenotype of Klebsiella pneumoniae in California sea lions (Zalophus californianus)

Cited by 46 publications

References 13 publications

First case report of non‐human primates (Alouatta clamitans) with the hypervirulent Klebsiella pneumoniae serotype K1 strain ST 23: A possible emerging wildlife pathogen

First case report of non‐human primates (Alouatta clamitans) with the hypervirulent Klebsiella pneumoniae serotype K1 strain ST 23: A possible emerging wildlife pathogen

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health

Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland

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