Pleuropulmonary complications in Rheumatoid Arthritis

Panda, Sanghamitra; Dash, Ashok Kumar; Taranikanti, Madhuri

doi:10.7439/ijbr.v3i6.484

Cited by 2 publications

(1 citation statement)

References 16 publications

(14 reference statements)

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“…Mean disease duration was 8.1 years. 10 But in our study most patients having pulmonary involvement having duration of illness between 0 to 3 years (66%), followed by 34% between the age more than 3years.This difference is because of lesser number of sample size included in the study. Vergnenegre et al, reported a significant correlation between abnormal FEF 25-75% and duration of articular disease in non-smokers with RA.…”

Section: Exclusion Criteriacontrasting

confidence: 49%

A study on diagnostic efficacy of pulmonary imaging tool in patients with rheumatoid arthritis

Gantait¹,

Gantait²,

Islam³

et al. 2019

Int J Res Med Sci

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Background: Pulmonary complication in Rheumatoid arthritis is major health concern in the field of rheumatology. So this study is to find out the sensitive imaging tool for detecting different types of pulmonary changes seen in RA.Methods: This is a comparative, analytical, cross sectional, Institution- based, single centre study. We included all adult willing patients of Rheumatoid arthritis (age >18) and selected them based on 2010 ACR/EULAR criteria. Severity was assessed by number of joints involve in both upper and lower limb, along with ESR, CRP, Anti CCP level. Chest x ray, PFT and HRCT thorax were done in all RA patients.Results: Out of 50 RA patients, pulmonary involvement was observed in 25 patients identified by Spirometry, CXR, HRCT. Pulmonary involvement is more common in age group <40 years. Most common form of pulmonary involvement is ILD followed by obstructive lung disease like chronic bronchitis, bronchiectasis etc. HRCT is the most common tool for detection of Pulmonary involvement in rheumatoid arthritis. HRCT abnormality, most are Restrictive on spirometry (FEV1/FVC) <80% of predicted value. And this relation is statistically significant as P value is 0.001 (<0.05) by Chi-Square test. Patients having more the disease duration, more the pulmonary involvement. This association is statically significant as p value is 0.001 (<0.05).Conclusions: High resolution CT thorax is more sensitive modality for detection of pulmonary pathology in rheumatoid arthritis. Because of its high cost, availability of this imaging technique is beyond the lower socio-economic group where chest x ray may be useful.

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Section: Exclusion Criteriacontrasting

confidence: 49%

A study on diagnostic efficacy of pulmonary imaging tool in patients with rheumatoid arthritis

Gantait¹,

Gantait²,

Islam³

et al. 2019

Int J Res Med Sci

View full text Add to dashboard Cite

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Rheumatoid Arthritis and Lung Disease: From Mechanisms to a Practical Approach

Lake

Proudman

2014

Semin Respir Crit Care Med

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Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease characterized by joint inflammation and, in a proportion of patients, extra-articular manifestations (EAM). Lung disease, either as an EAM of the disease, related to the drug therapy for RA, or related to comorbid conditions, is the second commonest cause of mortality. All areas of the lung including the pleura, airways, parenchyma, and vasculature may be involved, with interstitial and pleural disease and infection being the most common problems. High-resolution computed tomography of the chest forms the basis of investigation and when combined with clinical information and measures of physiology, a multidisciplinary team can frequently establish the diagnosis without the need for an invasive biopsy procedure. The most frequent patterns of interstitial lung disease (ILD) are usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), with some evidence for the prognosis being better than for the idiopathic equivalents. Risk factors depend on the type of disease but for ILD (mainly UIP and NSIP) include smoking, male gender, human leukocyte antigen haplotype, rheumatoid factor, and anticitrullinated protein antibodies (ACPAs). Citrullination of proteins in the lung, frequently thought to be incited by smoking, and the subsequent development of ACPA appear to play an important role in the development of lung and possibly joint disease. The biologic and nonbiological disease modifying antirheumatic drugs (DMARDs) have had a substantial impact on morbidity and mortality from RA, and although there multiple reports of drug-related lung toxicity and possible exacerbation of underlying ILD, overall these reactions are rare and should only preclude the use of DMARDs in a minority of patients. Common scenarios facing pulmonologists and rheumatologists are addressed using the current best evidence; these include screening the new patient; monitoring and choosing RA treatment in the presence of subclinical disease; treating deteriorating ILD; and establishing a diagnosis in a patient with an acute respiratory presentation.

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Pleuropulmonary complications in Rheumatoid Arthritis

Cited by 2 publications

References 16 publications

A study on diagnostic efficacy of pulmonary imaging tool in patients with rheumatoid arthritis

A study on diagnostic efficacy of pulmonary imaging tool in patients with rheumatoid arthritis

Rheumatoid Arthritis and Lung Disease: From Mechanisms to a Practical Approach

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