Pleurotus ostreatus as a Biocatalyst to Obtain Bicyclic Hydroxylactones with Three or Four Methyl Groups

Abstract

The purpose of the study was to explore microbial transformations in cultures of basidiomycetes Pleurotus ostreatus, two bicyclic unsaturated lactones occurring in the form of two diastereoisomers. Some of these strains were able to transform unsaturated lactones into four known and three new derivatives. The structures of all lactones were established on the basis of spectroscopic data. Both substrates and products caused a complete inhibition of growth of A. alternata and F. linii strains.

Antimicrobial Activity of Lactones

“…Interestingly, for unsaturated lactone 94 and its biotransformation product, hydroxyderivative 95 ( Figure 13 ), the tendency for antifungal activity was rather reversed. The most active was hydroxylactone 95 which, at 0.025 mg/mL, completely inhibited the growth of the Fusarium linii A3 strain [ 91 ].…”