Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus: successful diagnosis and treatment by endoscopy

Wang, Wei-Ya; Li, Jinnan; Li, Gan-di

doi:10.1136/jcp.2010.076646

Cited by 29 publications

(32 citation statements)

References 6 publications

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“…Imaging has a difficult role to distinguish it from other stromal tumours [7]. Although this case was diagnosed upon post-surgical histopathology, we recommend that, when myxoid spindle cell lesion is observed in endoscopic biopsy, PAMT should be included in diferential diagnosis [9].…”

Section: Resultsmentioning

confidence: 90%

“…Symptoms may include those of ulceration, hematemesis and anemia [2], our patient presented with intermittent epigastric discomfort and abdominal pain. Usually the endoscopist encounters a submucosal based or nodular mass [9]. A very striking feature is the almost exclusive location in the gastric antrum [3,4].…”

Section: Resultsmentioning

confidence: 99%

“…A very striking feature is the almost exclusive location in the gastric antrum [3,4]. The mucosa may be intact, dimpled or ulcerated [3,9]. Imaging has a difficult role to distinguish it from other stromal tumours [7].…”

Section: Resultsmentioning

confidence: 99%

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Plexiform Angiomyxoid Myofibroblastic Tumor (PAMT) of Stomach with Synchronous Bilateral Cystic Ovarian Neoplasms, a Rare Case Presentation

Dixit¹,

Sharief

Goyal³

et al. 2015

Indian J Surg Oncol

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Plexiform Angiomyxoid Myofibroblastic Tumor (PAMT) is a recently identified mesenchymal tumor of the stomach, which was first described in the year 2007 and was added in the 2010 WHO classification of tumors of the digestive system World J Gastroenterol 16(6): 2835-2840, 2010. It closely resembles with other gastric tumors but distinctly varies in clinical management as well as the histopathology. We had a 51 year, female patient, laborer by profession with low socio economic status, who had abdominal pain with vomiting since 6 months. She had similar complaints 3 years ago for which she was evaluated and presumed to have Carcinoma Stomach and underwent laparotomy which ended up only with Gastro-Jejunal anastomosis. She was admitted at our institution. Endoscopy revealed antral bulge with central area ulceration and biopsy was taken which was not confirmatory for malignancy. CT images showed heterogeneous mass with necrotic changes arising from the duodenum favored the diagnosis of perigastric neoplasm. PET CT was done, 8.4×5×6.1 cm exophytic mass in the pyloric region of stomach with solid and cystic components causing significant gastric outlet obstruction. She underwent exploratory laparotomy and complete excision of mass with achievement of R0 clearance. Histopathology was reported as Plexiform angiomyxoid myofibroblastic tumor (PAMT).

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

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Plexiform Angiomyxoid Myofibroblastic Tumor (PAMT) of Stomach with Synchronous Bilateral Cystic Ovarian Neoplasms, a Rare Case Presentation

Dixit¹,

Sharief

Goyal³

et al. 2015

Indian J Surg Oncol

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“…The antrum of the stomach is involved in 88% of reported cases, with contiguous involvement of the pylorus and/or duodenum in an additional 7 cases. Isolated examples of plexiform fibromyxoma have been documented in the gastric fundus (14), cecum (13), pyloroduodenal region (16) and posterior mediastinum (16).…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemically, plexiform fibromyxoma demonstrates a myofibroblastic phenotype with documented expression of SMA (n=26 cases) (1,2,4-10,14-18), vimentin (n=8) (2,4,6,13,14,16,18), muscle specific actin (n=6) (5,6,10,15), desmin (n=9) (4,5,7,8,10,(16)(17)(18), caldesmon (n=5) (5,6,10,18) and calponin (n=3) (5,10,16). Immunoexpression of CD10 (n=2) (1), nestin (n=1) (16) and progesterone receptor protein (n=1) (5) have also been documented.…”

Section: A B C Dmentioning

confidence: 99%

Plexiform fibromyxoma with cotyledon-like serosal growth: A case report of a rare gastric tumor and review of the literature

et al. 2016

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Abstract. Plexiform fibromyxoma is a rare, benign mesenchymal neoplasm that predilects the gastric antrum and has potential for misdiagnosis as a gastrointestinal stromal tumor (GIST). The histology of the tumor is characterized by interwoven fascicular growth of cytologically bland spindled cells within a variably myxoid stroma. The current study reports the clinicopathological and immunohistochemical findings of a plexiform fibromyxoma resected from a 28-year-old Vietnamese female. The patient presented with acute, severe abdominal pain and worsening anemia. The initial fine-needle aspiration and needle core biopsy of the gastric antral mass led to an initial diagnosis of GIST. The subsequent distal partial gastrectomy revealed a 5.5-cm transmural antral mass that ulcerated the overlying mucosa and grew as variably elongated, myxoedematous, polypoid (cotyledon-like) excrescences from the serosal surface. Microscopically, the tumor demonstrated plexiform and multinodular growth of cytologically bland spindled cells proliferating in an abundant myxocollagenous stroma with a prominent capillary network. Tumor cells immunohistochemically expressed smooth muscle actin and CD10, but did not express CD117, Discovered on GIST-1 or nuclear β-catenin. Follow-up evaluation 23 months post surgery revealed no evidence of residual tumor. A review the cases of this rare entity reported in the English language literature is also provided.

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Gastric Neoplastic Conditions

Clauditz

Lauwers

2021

Gastrointestinal Pathology

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Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus: successful diagnosis and treatment by endoscopy

Cited by 29 publications

References 6 publications

Plexiform Angiomyxoid Myofibroblastic Tumor (PAMT) of Stomach with Synchronous Bilateral Cystic Ovarian Neoplasms, a Rare Case Presentation

Plexiform Angiomyxoid Myofibroblastic Tumor (PAMT) of Stomach with Synchronous Bilateral Cystic Ovarian Neoplasms, a Rare Case Presentation

Plexiform fibromyxoma with cotyledon-like serosal growth: A case report of a rare gastric tumor and review of the literature

Gastric Neoplastic Conditions

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