Plexiform neurofibromas of the brachial plexuses

Paradowski, Bogusław; Bilińska, Małgorzata; Sąsiadek, Marek; Jeleń, Michał

doi:10.1212/01.wnl.0000163857.23551.2c

Cited by 4 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dermal neurofibromas might cause local discomfort and itching but are rarely associated with neurological deficit and do not undergo malignant change. The more extensive plexiform neurofibromas produce neurological complications in 27–43% of patients with neurofibromatosis 1 and might undergo malignant degeneration in 5% of cases 1,2 . Such tumours almost always present with pain and functional neuronal deficit 3 …”

Section: Neurological Involvementmentioning

confidence: 99%

Clinical challenges and serious vascular complications in neurofibromatosis

Faruque

Davidson

2009

Emerg Medicine Australasia

View full text Add to dashboard Cite

show abstract

Section: Neurological Involvementmentioning

confidence: 99%

Clinical challenges and serious vascular complications in neurofibromatosis

Faruque

Davidson

2009

Emerg Medicine Australasia

View full text Add to dashboard Cite

show abstract

Raumforderung im kleinen Becken im 2. Schwangerschafts-Trimenon

Fiedler¹,

Schleußner²,

Klemm³

et al. 2007

Gynäkologe

View full text Add to dashboard Cite

Benign peripheral nerve sheath tumors: an interdisciplinary diagnostic and therapeutic challenge

Uerschels,

Dengler,

Chihi

et al. 2023

Neurosurg Rev

View full text Add to dashboard Cite

A benign peripheral nerve sheath tumor (bPNST) is a rare lesion associated with peripheral nerval structures. Symptoms may be heterogeneous, complicating diagnosis finding. Additionally, management concepts of bPNST may vary. In some cases, initial misdiagnosis leads to mistreatment resulting in severe functional deficits and chronic pain syndromes. Therefore, we analyzed patients treated for bPNST in our specialized institution with a primary focus on prior misdiagnosis and possible mistreatment. Patients with bPNSTs (schwannomas, neurofibromas, hybrid nerve sheath tumors, and perineuriomas) treated at the Neurosurgical Department between January 1, 2015, and July 31, 2021, were included. Assessment of demographics, tumor entity, tumor location, symptoms, the interval between the onset of symptoms and surgery, involved medical specialties, and outpatients’ treatment, with particular focus on initial misdiagnosis and inappropriate medical treatment, was performed. Eighty-five patients were included in the final analysis with schwannoma being the most prevalent histopathological diagnosis (schwannoma (75.3%, n=64), neurofibroma (12.9%, n=11), hybrid nerve sheath tumor (5.9%, n=5), and perineurioma (5.9%, n=5)). An incorrect primary diagnosis was detected in 44.7% (n=38), leading to suboptimal or insufficient treatment in these cases. Of those, 28.9% (n=11/38) were treated suboptimal, while 18.5% (n=7/38) underwent unnecessary invasive diagnostics. Inappropriate surgery based on prior misdiagnosis, which led to severe neurological deficits in all these cases, was reported in 26.3% (n=10/38). For the first time, our data shows the quantity and impact of incorrect initial diagnosis in bPNST causing a delay in causative treatment or resulting in unnecessary or potentially harmful treatment.

show abstract

Plexiform neurofibromas of the brachial plexuses

Cited by 4 publications

References 2 publications

Clinical challenges and serious vascular complications in neurofibromatosis

Clinical challenges and serious vascular complications in neurofibromatosis

Raumforderung im kleinen Becken im 2. Schwangerschafts-Trimenon

Benign peripheral nerve sheath tumors: an interdisciplinary diagnostic and therapeutic challenge

Contact Info

Product

Resources

About