Plexiform schwannoma mimicking a salivary gland tumor: An unusual case report diagnosed in pediatric patient

Santos, Jean Nunes dos; Gurgel, Clarissa Araújo Silva; Ramos, Eduardo Antônio Gonçalves; Júnior, Fernando Bastos Pereira; Crusoé‐Rebello, Iêda; Oliveira, Márcio Campos

doi:10.1016/j.pedex.2011.02.007

Cited by 7 publications

(9 citation statements)

References 19 publications

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“…S-100 staining was employed in all of the 27 amenable cases, and showed strong immunoreactivity in all of the employed cases. Other authors revealed varying degrees of positive immunoreactivity with different stains: vimentin, 15 19 42 epithelial membrane antigen (EMA), 24 49 SOX-10 (present case), neuron specific enolase (NSE), 15 glial fibrillary acidic protein (GFAP), 24 CD-56 and CD-57, 24 and CD-34 and CD-117. 49 Immunonegative results were noted with the following stains: actin, 21 neurofilament protein (NFP), 24 52 smooth muscle antigen, 37 cytokeratin, 46 AE1/AE3, 24 and Calponin.…”

Section: Resultsmentioning

confidence: 62%

“…From the included articles, clinical, histopathological, radiological, and treatment findings were charted ( Tables 1 and 2 ). 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54…”

Section: Resultsmentioning

confidence: 99%

“…Of the histological variant, the conventional subtype dominated and was reported in 40 cases (87%). It was followed by plexiform-3, 13 24 29 ancient-2, 32 49 and cellular variant- 1. 48 Almost all of the cases with conventional phenotype exhibited Verocay bodies and a predominance of Antoni A areas over Antoni B areas.…”

Section: Resultsmentioning

confidence: 99%

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Palatal Schwannoma: An Analysis of 45 Literature Reports and of an Illustrative Case

Dokania

Rajguru

Mayashankar

et al. 2019

Int Arch Otorhinolaryngol

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Introduction Schwannomas are benign tumors originating from differentiated Schwann cells. Being the least common intraoral neoplasm of neural origin, it is rarely seen in the palate. The literature lacks an extensive review of intraoral schwannoma confined to the palate. Objective To review previously reported cases of palatal schwannoma along with an illustrative case, and to provide a better insight regarding clinicopathological and radiological features of this neural tumor in a rare intraoral site. Data Synthesis We present a case of palatal schwannoma in a 16-year-old female. An additional 45 cases were identified in 2 medical database searches (PubMed and Google Scholar) published from the year 1985 onwards, and from 13 countries, in the 5 continents. The ages of the patients ranged from 3 to 84 years old. Palatal schwannoma showed a slight predilection to females, with a male/female ratio of ∼ 1:1.81. Hard palate involvement is almost twice greater than soft palate involvement. Surgical excision was employed in almost all of the cases, and recurrence was reported only once. Conclusion Palatal schwannomas, although rare, have been reported both over the hard and the soft palate. They mostly present as a painless, firm, well-encapsulated, slow-growing solitary lesion over the lateral palatal aspect.Imaging can add to suspicion and can delineate a differential diagnosis, but the diagnosis is confirmed by pathological examination. Fine-needle aspiration cytology (FNAC) is almost always inconclusive. Immunohistochemistry can assist in confirming a diagnosis, but is more important to rule out close differentials. Complete surgical excision is the treatment of choice, and recurrence or malignant transformation are extremely rare.

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Section: Resultsmentioning

confidence: 62%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Palatal Schwannoma: An Analysis of 45 Literature Reports and of an Illustrative Case

Dokania

Rajguru

Mayashankar

et al. 2019

Int Arch Otorhinolaryngol

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show abstract

“…4,[17][18][19][20][21] Tükürük bezleriyle ilişkili şıvannomların nodüler yapıda olabildikleri gibi, pleksiform yapıda da olabilecekleri bildirilmektedir. 19,22 Fasyal sinirin dallarından kaynaklanan şıvannomlar erken dönemde asemptomatik olsalar da, lezyonun büyümesiyle fasyal paralizi oluşmasına neden olmaktadırlar. Yapılan araştırmalarda, fasyal paralizi olgularında, şıvannomların önemli bir etken olarak değerlendirilmesi gerektiği belirtilmektedir.…”

Section: Discussionunclassified

“…Bu özellikleriyle şıvannomun klinik ayırıcı tanısı lipoma, fibroma, benign tükürük bezi tümörleri, fibroepitelyal polip ve mukosellerle yapılabilir. [16][17][18][19][20][21][22][23][24] Ancak histolojik ayırıcı tanıda, nörofibroma ve nöroma gibi diğer nöral orijinli tümöral oluşumlar da düşünülmelidir. 21 Bu vakada operasyon sonrası klinik ön tanı; fibrom ya da pleomorfik adenoma olarak konulmuş, ancak histopatolojik inceleme sonucunda periferik sinir kılıfı tümörü, şıvannom olduğu görülmüştür.…”

Section: Discussionunclassified