Plexiform structures in malignant schwannomas after prenatal exposure to ethylnitrosourea

Cardesa, Antonio; Llanes, Felipe; Merchán, Jaime A.; Alvarez, Tomas; Ludeña, María Dolores; Möhr, U.

doi:10.1016/s0232-1513(83)80023-1

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…However, intracranial malignant Schwannomas that were chemically induced in hooded rats had scattered pigmented cells that contained melanosomes and premelanosomes (27). Ultrastructurally, in this study, amelanotic melanoma cells were readily distinguished from neoplastic Schwann cells by the absence of the pericytoplasmic basal lamina, which is the crucial histogenetic criterion for Schwannoma cells (4,10,12,17,30).…”

Section: Introductionmentioning

confidence: 63%

“…Schwann cell tumors occur in various tissues and organs in albino rats, but the presence of premelanosomes in neoplastic Schwann cells has never been reported (4,12,17,24,30). However, intracranial malignant Schwannomas that were chemically induced in hooded rats had scattered pigmented cells that contained melanosomes and premelanosomes (27).…”

Section: Introductionmentioning

confidence: 99%

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Pathology and Incidence of Amelanotic Melanomas of the Skin in F-344/N Rats

Yoshitomi¹,

Elwell

Boorman

1995

Toxicol Pathol

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Pathology and Incidence of Amelanotic Melanomas of the Skin in F-344/N Rats

Yoshitomi¹,

Elwell

Boorman

1995

Toxicol Pathol

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Experimental model of tumors associated with neurofibromatosis

Cardesa

Ribalta

Schilling

et al. 1990

Cancer

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Four groups of animals, each composed of 22 pregnant Wistar rats, were used in this study. Single intraperitoneal (IP) injections of ethylnitrosourea (ENU) at a dose of 15 mg/kg body weight (BW) were given to the animals of two groups on days 15 and 21 of pregnancy, respectively. The progeny of a third group received by subcutaneous injection (SC) the same dose of ENU, 15 mg/kg BW, on day 1 postnatally. The descendants of the fourth group served as untreated controls. The most striking findings were observed in the progeny of the mothers treated on day 15 of pregnancy, in which group 64 of 180 descendants developed peripheral nervous system (PNS) tumors, 30% of which had plexiform pattern. One hundred fifteen of the 180 descendants developed central nervous system (CNS) gliomas, mainly oligodendrogliomas, and five animals presented with Wilms' tumors. No tumors of these types were observed in the untreated controls. Although descendants of mothers treated on day 21 of pregnancy had the highest number of PNS tumors (130 of 172 animals), only 21% of these tumors were plexiform; CNS gliomas were observed in 78 animals and Wilm's tumors in one animal. The lowest percentage of PNS tumors with plexiform pattern (16%) was found in the group of 157 descendants treated postnatally on day 1, in which 88 animals developed PNS tumors, 76 developed CNS gliomas, and no animals developed Wilms' tumors. The higher percentage of plexiform PNS tumors found in the descendants treated prenatally on day 15 of pregnancy was statistically significant (P less than 0.05) when compared with the percentage found in the group treated postnatally. This significance was also valid for the plexiform tumors that developed selectively from branches of the trigeminal nerves (of the PNS tumors from this location, 48% showed a plexiform pattern), but only in the progeny exposed to ENU on day 15 of pregnancy. This same progeny also had the highest numbers of CNS and Wilms' tumors. Because in humans, plexiform neurofibromas are considered to be the neoplastic markers of neurofibromatosis, and CNS gliomas as well as Wilms' tumors are associated with this disease, it is suggested that exposure to ENU on day 15 of pregnancy, under the experimental conditions described here, may offer a model for investigating tumors associated with neurofibromatosis, as well as aspects of the spontaneous, noninherited forms of this disease.

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Nephroblastoma, Kidney, Rat

Cardesa¹,

Ribalta²

1998

Urinary System

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Plexiform structures in malignant schwannomas after prenatal exposure to ethylnitrosourea

Cited by 9 publications

References 23 publications

Pathology and Incidence of Amelanotic Melanomas of the Skin in F-344/N Rats

Pathology and Incidence of Amelanotic Melanomas of the Skin in F-344/N Rats

Experimental model of tumors associated with neurofibromatosis

Nephroblastoma, Kidney, Rat

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