PLGA Based Drug Carrier and Pharmaceutical Applications: The Most Recent Advances

Loureiro, Joana A.; Pereira, Maria do Carmo

doi:10.3390/pharmaceutics12090903

Cited by 44 publications

(25 citation statements)

References 35 publications

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“…A very important issue in PDT is to avoid the accumulation of PS in healthy tissues and prevent unwanted effects, which can be solved by using encapsulated PS in polymeric nanoparticles, in which the active product is protected from degradation by the physiological environment; an example is the case of poly (lactic-co-glycolic acid) (PLGA), recognized as one of the most valuable drug-carrying polymers (DCs) that is used to obtain high quality products. PLGA polymer is approved as a biocompatible and biodegradable polymer by the FDA and the European Medicines Agency (EMA) [118][119][120].…”

Section: Gynecologic Cancersmentioning

confidence: 99%

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Ailioaie

Litscher

2021

Pharmaceutics

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In the context of the high incidence of cancer worldwide, state-of-the-art photodynamic therapy (PDT) has entered as a usual protocol of attempting to eradicate cancer as a minimally invasive procedure, along with pharmacological resources and radiation therapy. The photosensitizer (PS) excited at certain wavelengths of the applied light source, in the presence of oxygen releases several free radicals and various oxidation products with high cytotoxic potential, which will lead to cell death in irradiated cancerous tissues. Current research focuses on the potential of natural products as a superior generation of photosensitizers, which through the latest nanotechnologies target tumors better, are less toxic to neighboring tissues, but at the same time, have improved light absorption for the more aggressive and widespread forms of cancer. Curcumin incorporated into nanotechnologies has a higher intracellular absorption, a higher targeting rate, increased toxicity to tumor cells, accelerates the activity of caspases and DNA cleavage, decreases the mitochondrial activity of cancer cells, decreases their viability and proliferation, decreases angiogenesis, and finally induces apoptosis. It reduces the size of the primary tumor, reverses multidrug resistance in chemotherapy and decreases resistance to radiation therapy in neoplasms. Current research has shown that the use of PDT and nanoformulations of curcumin has a modulating effect on ROS generation, so light or laser irradiation will lead to excessive ROS growth, while nanocurcumin will reduce the activation of ROS-producing enzymes or will determine the quick removal of ROS, seemingly opposite but synergistic phenomena by inducing neoplasm apoptosis, but at the same time, accelerating the repair of nearby tissue. The latest curcumin nanoformulations have a huge potential to optimize PDT, to overcome major side effects, resistance to chemotherapy, relapses and metastases. All the studies reviewed and presented revealed great potential for the applicability of nanoformulations of curcumin and PDT in cancer therapy.

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Section: Gynecologic Cancersmentioning

confidence: 99%

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Ailioaie

Litscher

2021

Pharmaceutics

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“…These are few important polyesters approved by the Food and Drug Administration (FDA) for human administration due to their extraordinary biocompatibility and biodegradability properties. 6,61,[78][79][80][81] Their hydrolytic degradation in the body lead to the formation of non-toxic products such as lactic acid and glycolic acid products, which can be eliminated from the body in the form of CO 2 and water. 82 The nanoparticles of PLGA/ S C H E M E 7 Synthetic route for the covalent incorporation of N,N-bis (hydroxyethyl)isonicotinamide into the poly(ε-CL) chain by the dispersion of ROP of ε-CL in the presence of poly(DA)-g-poly(ε-CL) surfactant.…”

Section: Poly(lactic Acid) and Poly(lactic-co-glycolic Acid) Based Nanoparticles Loaded With Bioactive Compounds And Drugsmentioning

confidence: 99%

“…61,78,79,83,84 Their utility is also well explored for different therapeutic applications including vaccinations, cancer, neurological disorders, inflammation, etc. 6,61,[78][79][80][81] Although several review articles already covered the importance of PLA/PLGA particles for drug/gene/vaccine delivery applications, 6,61,[78][79][80][81] in this section we are focusing on a few exciting recent advances in this era for the readers benefit.…”

Section: Poly(lactic Acid) and Poly(lactic-co-glycolic Acid) Based Nanoparticles Loaded With Bioactive Compounds And Drugsmentioning

confidence: 99%

Formation of micro/nanoparticles and microspheres from polyesters by dispersion ring‐opening polymerization

Reddy

Domb

2021

Polymers for Advanced Techs

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The micro/nanoparticles and microspheres of polyesters derived from the heterocyclic monomers of lactide (L,L or D,L), ε-caprolactone, and glycolide have received significant interest as drug carriers for biomedical applications. This review focuses on the recent advances in the study of polyester-based micro/nanoparticles and microspheres derived from the dispersion ring-opening polymerization (ROP) of heterocyclic monomers, and/or self-assembly of polyester macromolecules, and/or dialysis of polyester solution in water-miscible organic solvents against water. The dispersion polymerization of heterocyclic monomers in the presence of non-polar miscible solvents and amphiphilic polymer surfactant leads to the formation of polyester particles with a narrower size distribution. The use of the polymer surfactant is crucial in controlling the diameter, morphology, and stability of the polyester particles formed during the ROP. The polymer surfactant acts as a stabilizer and is bound to the polyester particles strongly and irreversibly to control the size and morphology of polyester microspheres. The properties of polyester particles are varied by controlling the number average diameter and diameter polydispersity index. Hence, in this article, we review different synthetic strategies developed for the formation of polyester based particles with controlled diameter of distribution and the factors influencing its formation such as structure of the polymer surfactant, critical micelle concentration of the surfactant, type of radical initiator/monomer used, reaction parameters, etc. The article also describes methods developed for transforming the polyester microspheres into the water for better biocompatibility and encapsulation of bioactive compounds, drugs, and proteins into the polyester particles and their potential release at the targeted specific site are reviewed.dispersion ring opening polymerization, drug carriers, micro/nanoparticles, microspheres, polyester particles | INTRODUCTIONRing-opening polymerization (ROP) is a well-known and frequently applied method for the synthesis of polymers with heteroatoms in their main chain chemical structure. Examples of polymers obtained from the ROP include polyesters, polycarbonates, polyphosphazene, and polypeptides. [1][2][3][4][5][6] These polymers are usually obtained in solution and shapeless precipitates. Very few are reported as well-dispersed and spherical micro/nanospheres. [7][8][9][10][11][12][13] Among these, the polymerbased on micro/nanospheres have very significant applications in medicine as a synthetic carrier for drug and gene delivery. They also have applications in tissue engineering as building scaffolds. [7][8][9][10][11][12][13]

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“…Poly (D, L-lactide- co -glycolide) (PLGA) is a biocompatible and biodegradable polyester copolymer, which enables the growth of new tissue while it is degraded and provides rigidity and stability to the scaffold [ 23 , 24 ]. Furthermore, this polymer has been accepted by different health agencies such as the FDA for its use in a wide variety of therapeutic devices [ 25 ]. Poly (ethylene glycol) (PEG) is a highly hydrophilic biocompatible polymer that combined in its methacrylated form (PEGDMA) is a highly hydrophilic polymer that can be formed as a crosslinked hydrogels by means of advanced methods of manufacturing porous matrices [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Gradient Scaffolds Containing Hyaluronic Acid and Sr/Zn Folates for Osteochondral Tissue Engineering

et al. 2021

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Regenerative therapies based on tissue engineering are becoming the most promising alternative for the treatment of osteoarthritis and rheumatoid arthritis. However, regeneration of full-thickness articular osteochondral defects that reproduces the complexity of native cartilage and osteochondral interface still remains challenging. Hence, in this work, we present the fabrication, physic-chemical characterization, and in vitro and in vivo evaluation of biomimetic hierarchical scaffolds that mimic both the spatial organization and composition of cartilage and the osteochondral interface. The scaffold is composed of a composite porous support obtained by cryopolymerization of poly(ethylene glycol) dimethacrylate (PEGDMA) in the presence of biodegradable poly(D,L-lactide-co-glycolide) (PLGA), bioactive tricalcium phosphate β-TCP and the bone promoting strontium folate (SrFO), with a gradient biomimetic photo-polymerized methacrylated hyaluronic acid (HAMA) based hydrogel containing the bioactive zinc folic acid derivative (ZnFO). Microscopical analysis of hierarchical scaffolds showed an open interconnected porous open microstructure and the in vitro behaviour results indicated high swelling capacity with a sustained degradation rate. In vitro release studies during 3 weeks indicated the sustained leaching of bioactive compounds, i.e., Sr2+, Zn2+ and folic acid, within a biologically active range without negative effects on human osteoblast cells (hOBs) and human articular cartilage cells (hACs) cultures. In vitro co-cultures of hOBs and hACs revealed guided cell colonization and proliferation according to the matrix microstructure and composition. In vivo rabbit-condyle experiments in a critical-sized defect model showed the ability of the biomimetic scaffold to promote the regeneration of cartilage-like tissue over the scaffold and neoformation of osteochondral tissue.

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PLGA Based Drug Carrier and Pharmaceutical Applications: The Most Recent Advances

Abstract: Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers that has been used to produce medicines, such as drug carriers (DC) [...]

Cited by 44 publications

References 35 publications

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Formation of micro/nanoparticles and microspheres from polyesters by dispersion ring‐opening polymerization

Biomimetic Gradient Scaffolds Containing Hyaluronic Acid and Sr/Zn Folates for Osteochondral Tissue Engineering

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