PLGA nano‐ and microparticles for the controlled release of florfenicol: Experimental and theoretical study

Abstract

In this study, PLGA particle systems were studied for the controlled release of florfenicol, a broad spectrum antibiotic used in veterinary treatments. The emulsion-solvent evaporation technique was used for particle preparation. To evaluate the particle size, entrapment efficiency, and drug release behavior, factors such as solvent type, emulsification time and methods, and drug to polymer ratio were investigated. The results showed that the use of ethyl acetate and 2.5 min of ultrasonication or 30 min of homogenization can lead to sub-micron and micron-sized particles, respectively. Sizes between 200-300 nm and 2-3 μm were obtained for ultrasonication and homogenization procedures, respectively. Entrapment efficiencies were around 20% for all systems and release profiles were size dependent. In addition, a mathematical model was implemented to simulate the florfenicol transport. The model predicts the florfenicol release and takes into account the particle size, polymer molecular weight, and autocatalytic polymer degradation. Simulation results are in good agreement with experimental results.

Modulating drug release from poly(lactic‐co‐glycolic) acid microparticles by the addition of alginate and pectin

“…A very good agreement with the experimental results of Til release is observed. The parameters adjusted in our previous work were used for simulations corresponding to Degradation and Release Modules 2 . The estimated values of the drug effective diffusivity at the different pH conditions for MP.H2O microparticles are shown in Table 2.…”

“…A mathematical model was implemented in order to predict the controlled release of tilmicosin from PLGA microparticles incorporating alginate and pectin. It was extended from our previous work and it takes into account the polymer degradation and the drug transport through the polymeric matrix 2 . The mathematical model consists of two modules: Degradation module and release module.…”

“…The decrease in the number of doses, secondary effects reduction, and patient/client acceptance are the main objectives related to the design of DDT. In this regard, new technological approaches based on controlled release systems have been developed to improve drug stability and/or bioavailability in specific organs and organelles 1,2 . Controlled release systems consist of a combination of drugs with other excipients, such as natural and/or synthetic polymers.…”

“…On the other hand, the reduction in the indiscriminate use of antibiotics is a matter of increasing interest due to the emergence of microbial antibiotic resistance (MDR) declared by the WHO. In this sense, DDT designed for antibiotics encapsulation intent to overcome the mentioned problems 1,2,22 . Tilmicosin (Til) is a slightly water soluble macrolide antibiotic synthesized from tylosin.…”

Towards a better understanding of the release mechanisms of caffeine from PLGA microparticles

“…Poly(lactic‐ co ‐glycolic acid) (PLGA) is frequently used as a polymeric matrix former in controlled drug delivery systems, in particular microparticles, scaffolds, nanofibers, and implants . This type of advanced drug products allows to preprogram the release rate of the active agent into the human body after injection or implantation.…”