PLGA Nanofiber/PDMS Microporous Composite Membrane-Sandwiched Microchip for Drug Testing

Li, Wei; Sun, Xindi; Ji, Bing; Yang, Xingyuan; Zhou, Bingpu; Lu, Zhanjun; Gao, Xinghua

doi:10.3390/mi11121054

Cited by 16 publications

(8 citation statements)

References 41 publications

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“…Ingber demonstrated the excellent properties of PU made from GS polymer and procedures for creating strong bonds to itself. PDMS was found to have a greater transmittance than PU for 97 Carter et al, 98 Li et al, 99 Ferrari et al, 100 Guo et al, 101 2 SU-8 mechanical strength, optical transparency, chemically stable, resistant toward other solvents adhesion selectivity, stress and resist stripping pancreas-liver-on-a-chip and blood-brain barrier modeling Essaouiba et al, 102 Zakharova et al 103 3 POMaC biodegradable, nontoxic, inexpensive, controllable mechanical and degradation properties, and simple fabrication soft tissue engineering, heart-on-a-chip, and liveron-a-chip Zhao et al, 329 Lai et al, 87 Polidoro et al 104 4 polystyrene optically transparency, biocompatible, rigid, easy surface functionalization, and inexpensive high cost equipments, poor resistance toward to other solvents biosensors, blood-brain-barrier model, multilayer devices, and drug analysis Bossink et al, 105 Zakharova et al, 103 Paoli et al, 106 Onbas et al 107 5 P(OCS) and PICO nontoxic, biocompatible, inexpensive, good machine strength, easy surface functionalization tissue engineering Huyer et al, 95 wavelengths of <300 nm, while the material transmittances remained equivalent at higher wavelengths (>350 nm). 30 This is essential as in fluorescence spectroscopy, where higher wavelengths are more sensitive for assays, which is crucial in the drug-development stage.…”

Section: Classification Of Ooc Materials Polydimethylsiloxane (Pdms) ...mentioning

confidence: 98%

Advances in Organ-on-a-Chip Materials and Devices

Nahak¹,

Mishra²,

Preetam³

et al. 2022

ACS Appl. Bio Mater.

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The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical to clinical translational precision. The current trends in the in vitro modeling is to reduce the complexity of human organ anatomy to the fundamental cellular microanatomy as an alternative of recreating the entire cell milieu that allows systematic analysis of medicinal absorption of compounds, metabolism, and mechanistic investigation. The OoC devices accurately represent human physiology in vitro; however, it is vital to choose the correct chip materials. The potential chip materials include inorganic, elastomeric, thermoplastic, natural, and hybrid materials. Despite the fact that polydimethylsiloxane is the most commonly utilized polymer for OoC and microphysiological systems, substitute materials have been continuously developed for its advanced applications. The evaluation of human physiological status can help to demonstrate using noninvasive OoC materials in real-time procedures. Therefore, this Review examines the materials used for fabricating OoC devices, the application-oriented pros and cons, possessions for device fabrication and biocompatibility, as well as their potential for downstream biochemical surface alteration and commercialization. The convergence of emerging approaches, such as advanced materials, artificial intelligence, machine learning, three-dimensional (3D) bioprinting, and genomics, have the potential to perform OoC technology at next generation. Thus, OoC technologies provide easy and precise methodologies in cost-effective clinical monitoring and treatment using standardized protocols, at even personalized levels. Because of the inherent utilization of the integrated materials, employing the OoC with biomedical approaches will be a promising methodology in the healthcare industry.

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Section: Classification Of Ooc Materials Polydimethylsiloxane (Pdms) ...mentioning

confidence: 98%

Advances in Organ-on-a-Chip Materials and Devices

Nahak¹,

Mishra²,

Preetam³

et al. 2022

ACS Appl. Bio Mater.

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“…Aiming to simulate the lung tumor microenvironment for chemotherapeutic drug screening applications, a lung ToC device was constructed using an electrospun PLGA membrane as a substrate for cell culture [129,130]. Exposure of the coculture of human lung non-small cell lung cancer cell line A549 and human fetal lung fibroblast HFL1 cells to the epidermal growth factor receptor EGFR-targeted drug gefitinib showed A549 cell resistance.…”

Section: Lung Platformsmentioning

confidence: 99%

Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives

et al. 2021

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Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms.

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“…At present, polydimethylsiloxane (PDMS) is the main material of lung chips, and lung chips are mainly prepared via soft lithography [ 23 , 24 , 25 , 26 ], but the photoresist template preparation steps are cumbersome, requiring glue mixing, baking, exposure, development, etc. When using emerging 3D printing technology to prepare lung chips, the operation is simple, the preparation cost is low, and the chips can be mass-produced.…”

Section: Introductionmentioning

confidence: 99%

Exploratory Evaluation of EGFR-Targeted Anti-Tumor Drugs for Lung Cancer Based on Lung-on-a-Chip

et al. 2022

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In this study, we used three-dimensional (3D) printing to prepare a template of a microfluidic chip from which a polydimethylsiloxane (PDMS)lung chip was successfully constructed. The upper and lower channels of the chip are separated by a microporous membrane. The upper channel is seeded with lung cancer cells, and the lower channel is seeded with vascular endothelial cells and continuously perfused with cell culture medium. This lung chip can simulate the microenvironment of lung tissue and realize the coculture of two kinds of cells at different levels. We used a two-dimensional (2D) well plate and a 3D lung chip to evaluate the effects of different EGFR-targeting drugs (gefitinib, afatinib, and osimertinib) on tumor cells. The 3D lung chip was superior to the 2D well plate at evaluating the effect of drugs on the NCI-H650, and the results were more consistent with existing clinical data. For primary tumor cells, 3D lung chips have more advantages because they simulate conditions that are more similar to the physiological cell microenvironment. The evaluation of EGFR-targeted drugs on lung chips is of great significance for personalized diagnosis and treatment and pharmacodynamic evaluation.

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PLGA Nanofiber/PDMS Microporous Composite Membrane-Sandwiched Microchip for Drug Testing

Cited by 16 publications

References 41 publications

Advances in Organ-on-a-Chip Materials and Devices

Advances in Organ-on-a-Chip Materials and Devices

Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives

Exploratory Evaluation of EGFR-Targeted Anti-Tumor Drugs for Lung Cancer Based on Lung-on-a-Chip

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