PLGA Nanoparticles and Polysorbate-80-Coated PLGA Nanoparticles Increase the In vitro Antioxidant Activity of Melatonin

Abstract

Cytotoxicity over erythrocytes was assessed and both nanoparticles containing MLT demonstrated lack of hemolysis. Scavenging activity over ABTS·+ demonstrated both nanoparticles containing MLT were more efficient than free drug, and MLT-loaded PLGA nanoparticles presented the higher in vitro antioxidant activity. The study concluded that PLGA and PLGA-PS80 nanoparticles are promising carriers for MLT.

The Release Kinetics of Melatonin from Innovative Dosage Forms: The Role of the Fractal Geometry of the “Vehicle”

“…The sizes of the PLGA-PS80 and PLGA nanoparticles were 212 and 187 nm, and the encapsulation entrapment of melatonin was 26 and 41%, respectively [37]. The release kinetics of melatonin followed the second-order model during studies from nanoparticles, while PLGA-PS80 presented more prolonged melatonin release [37]. The spherical shape of nanoparticles and the strong interactions due to negative zeta potential are the possible explanation of the release kinetics of melatonin from nanoparticles [37].…”

“…Additionally, PLGA nanoparticles and polysorbate 80-coated PLGA nanoparticles (PLGA-PS80) increase the in vitro antioxidant activity of melatonin [36]. The sizes of the PLGA-PS80 and PLGA nanoparticles were 212 and 187 nm, and the encapsulation entrapment of melatonin was 26 and 41%, respectively [37]. The release kinetics of melatonin followed the second-order model during studies from nanoparticles, while PLGA-PS80 presented more prolonged melatonin release [37].…”

Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma

“…Furthermore, the amount of polymer resulted lower than the one necessary for the physical mixture of microspheres resulting in a good tolerance of the formulation. Although the neuroprotective efficacy of other drug delivery systems has previously been reported [94][95][96][97], to the authors' knowledge, this is the first study to present an effective intraocular drug delivery system (IODDS) loaded with three drug cargo for the treatment of retinal degeneration.…”

Targeting Cancer Stem Cells to Overcome Chemoresistance

“…Liposomes were first described in the early seventies [197,198,199]. They are made of a copolymer of polylactic acid and polyglycolic acid [200,201], covered with polyethylene glycol (PEG) to decrease their captation by the reticuloendothelial system and, thus, increase their serum half-life [202]. In vitro, liposomal doxorubicin had a higher sensitivity than doxorubicin in chemoresistant CH LZ cells [203].…”