PLGA/PCADK composite microspheres containing hyaluronic acid–chitosan siRNA nanoparticles: A rational design for rheumatoid arthritis therapy

Zhao, Menghui; Zhu, Tianyu; Chen, Ji-Cong; Cui, Yaxin; Zhang, Xueyan; Lee, Robert J.; Sun, Fengying; Li, Youxin; Teng, Lesheng

doi:10.1016/j.ijpharm.2021.120204

Cited by 23 publications

(7 citation statements)

References 49 publications

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“…As a new biomaterial, it is more and more widely used in the medical field. It has significant advantages, such as prolonging the half-life of drugs, reducing the dosage and frequency of administration, enhancing the curative effect, reducing the toxicity of drugs, increasing the accumulation of drugs in tissues, and realizing diversified routes of Administration ( Chen et al, 2017 ; Hu et al, 2020a ; Zhao et al, 2021 ). The preparation of silk fibroin nanoparticles has become a current hotspot.…”

Section: Applications In Drug Delivery Systemmentioning

confidence: 99%

Research progress of natural silk fibroin and the application for drug delivery in chemotherapies

Li²,

Lin³

et al. 2023

Front. Pharmacol.

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Silk fibroin has been widely used in biological fields due to its biocompatibility, mechanical properties, biodegradability, and safety. Recently, silk fibroin as a drug carrier was developed rapidly and achieved remarkable progress in cancer treatment. The silk fibroin-based delivery system could effectively kill tumor cells without significant side effects and drug resistance. However, few studies have been reported on silk fibroin delivery systems for antitumor therapy. The advancement of silk fibroin-based drug delivery systems research and its applications in cancer therapy are highlighted in this study. The properties, applications, private opinions, and future prospects of silk fibroin carriers are discussed to understand better the development of anti-cancer drug delivery systems, which may also contribute to advancing silk fibroin innovation.

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Section: Applications In Drug Delivery Systemmentioning

confidence: 99%

Research progress of natural silk fibroin and the application for drug delivery in chemotherapies

Li²,

Lin³

et al. 2023

Front. Pharmacol.

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“… [142] Microspheres loaded with HA CH nanoparticles PLGA loaded and CADK siRNA MCL-1 Particle size: 113.6 nm PDI: 0.154 ± 0.013 Zeta potential: 15.0 ± 0.38 mV EE: 90.02% ± 3.02% SD rats Intravenously injected /Intramuscularly injected Sustained release of nanoparticles in microsphere, protected siRNA from nuclease degradation and readily cross the cellular membrane. [143] SWCNTs HiPco- and carboxyl-SWCNT siRNA Notch1 (siRNA/MTX loaded nanotubes) Particle size: 407.67±120.21 PDI: 0.087 Mice Intraperitoneally injected Accumulation in inflamed joints, improve targeting specificity to neutrophils. No impact on B cells and monocytes.…”

Section: Potential Of Sirna Delivery In the Treatment Of Arthritismentioning

confidence: 99%

The emerging potential of siRNA nanotherapeutics in treatment of arthritis

Kumari,

Kaur,

Aggarwal

2023

Asian Journal of Pharmaceutical Sciences

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“…The particle-size distributions of LP-ERN and Tf-LP-ERN nanoparticles were measured at 25°C using a particle size analyzer (Nano ZS90, Malvern Instruments, Malvern, Worcestershire, UK) at 25°C (25).…”

Section: Characterization Of Lp-ern and Tf-lp-ernmentioning

confidence: 99%

“…The surface morphologies of LP-ERN and Tf-LP-ERN nanoparticles dropped onto a silicon wafer at 3,000 V were observed by field-emission scanning electron microscopy (FESEM; JSM-6700F, JEOL, Tokyo, Japan) (25).…”

Section: Morphological Investigationmentioning

confidence: 99%

Transferrin-Conjugated Erianin-Loaded Liposomes Suppress the Growth of Liver Cancer by Modulating Oxidative Stress

Yang

Sun

et al. 2021

Front. Oncol.

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BackgroundLiver cancer is one of the most malignant human cancers, with few treatments and a poor prognosis. Erianin (ERN) is a natural compound with multiple pharmacological activities that has been reported to have numerous excellent effects against liver cancer in experimental systems. However, its application in vivo has been limited due to its poor aqueous solubility and numerous off-target effects. This study aimed to improve the therapeutic efficacy of ERN by developing novel ERN-loaded tumor-targeting nanoparticles.ResultsIn this study, ERN was loaded into liposomes by ethanol injection (LP-ERN), and the resulting LP-ERN nanoparticles were treated with transferrin to form Tf-LP-ERN to improve the solubility and enhance the tumor-targeting of ERN. LP-ERN and Tf-LP-ERN nanoparticles had smooth surfaces and a uniform particle size, with particle diameters of 62.60 nm and 88.63 nm, respectively. In HepG2 and SMMC-7721 cells, Tf-LP-ERN induced apoptosis, decreased mitochondrial membrane potentials and increased ERN uptake more effectively than free ERN and LP-ERN. In xenotransplanted mice, Tf-LP-ERN inhibited tumor growth, but had a minimal effect on body weight and organ morphology. In addition, Tf-LP-ERN nanoparticles targeted tumors more effectively than free ERN and LP-ERN nanoparticles, and in tumor tissues Tf-LP-ERN nanoparticles promoted the cleavage PARP-1, caspase-3 and caspase-9, increased the expression levels of Bax, Bad, PUMA, and reduced the expression level of Bcl-2. Moreover, in the spleen of heterotopic tumor model BALB/c mice, ERN, LP-ERN and Tf-LP-ERN nanoparticles increased the expression levels of Nrf2, HO-1, SOD-1 and SOD-2, but reduced the expression levels of P-IKKα+β and P-NF-κB, with Tf-LP-ERN nanoparticles being most effective in this regard. Tf-LP-ERN nanoparticles also regulated the expression levels of TNF-α, IL-10 and CCL11 in serum.ConclusionTf-LP-ERN nanoparticles exhibited excellent anti-liver cancer activity in vivo and in vitro by inducing cellular apoptosis, exhibiting immunoregulatory actions, and targeting tumor tissues, and did so more effectively than free ERN and LP-ERN nanoparticles. These results suggest that the clinical utility of a Tf-conjugated LP ERN-delivery system for the treatment of liver cancer warrants exploration.

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PLGA/PCADK composite microspheres containing hyaluronic acid–chitosan siRNA nanoparticles: A rational design for rheumatoid arthritis therapy

Cited by 23 publications

References 49 publications

Research progress of natural silk fibroin and the application for drug delivery in chemotherapies

Research progress of natural silk fibroin and the application for drug delivery in chemotherapies

The emerging potential of siRNA nanotherapeutics in treatment of arthritis

Transferrin-Conjugated Erianin-Loaded Liposomes Suppress the Growth of Liver Cancer by Modulating Oxidative Stress

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