PLGA-PEG-fucoxanthin nanoparticles protect against ischemic stroke in vivo

Wang, Qiyao; Zhang, Difan; Lü, Jing; Zhang, Jiaying; Xuan, Zhenquan; Gong, Luyun; Yang, Mengxiang; Jin, Liping; Le, Jingyang; An, Zhongfu; Liang, Hongze; Naman, C. Benjamin; Zhang, Jinrong; Zhao, Li; He, Shan; Wang, Qinwen; Líu, Hao; Yan, Xiangqiao; Zhao, Lingling; Cui, Wei

doi:10.1016/j.jff.2022.105359

Cited by 1 publication

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, treatment with fucoxanthin prevented NF-κB p65 expression in the hippocampus, cortex, and hypothalamus of LPS-injected depressive mice (98) and the production of TNF-α in MCAO-induced rats. (83) In this review, we discuss the existing literature on the potential of fucoxanthin to protect mitochondria in brain disorders. However, we acknowledge limitations.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In addition, the infarct volumes and brain oedema extents were decreased in rats receiving the nanoparticle treatment. (83) Furthermore, PLGA-PEG fucoxanthin nanoparticles prevented the loss of glutathione peroxidase, SOD, and catalase activity in the ischaemic brain indicating the roles of these compounds in regulating antioxidant defence. Fucoxanthin nanoparticles exhibit anti-inflammatory properties through the inactivation of the NF-κB pathway.…”

Section: Cerebral Ischaemiamentioning

confidence: 95%

“…Consistent with in vivo data, rat cortical neurones treated with fucoxanthin showed anti-apoptotic properties in response to oxygen-glucose deprivation and reoxygenation challenges. (82) Furthermore, the study suggested that fucoxanthin increased antioxidant proteins such as SOD (82) via the activation of Nrf2, (83) thereby protecting neurones from oxidative stress. Wang et al used PLGA-PEG nanoparticles to increase fucoxanthin bioavailability in the brains of MCAO-induced rats.…”

Section: Cerebral Ischaemiamentioning

confidence: 99%

“…Wang et al used PLGA-PEG nanoparticles to increase fucoxanthin bioavailability in the brains of MCAO-induced rats. (83) PLGA-PEG encapsulation improves fucoxanthin stability in the body and allows for its extended release and enhanced penetration into the central nervous system. The results of that study showed that the intravenous administration of PLGA-PEG fucoxanthin nanoparticles (20 and 40 mg/kg) half an hour before MCAO reduced the behavioural deficits associated with cerebral ischaemia in the rats.…”

Section: Cerebral Ischaemiamentioning

confidence: 99%

See 4 more Smart Citations

Mitochondrial protective potential of fucoxanthin in brain disorders

Ferdous,

Jansen,

Amjad

et al. 2024

J Nutr Sci

View full text Add to dashboard Cite

Mitochondrial dysfunction is a common feature of brain disorders. Mitochondria play a central role in oxidative phosphorylation; thus changes in energy metabolism in the brain have been reported in conditions such as Alzheimer’s disease, Parkinson’s disease, and stroke. In addition, mitochondria regulate cellular responses associated with neuronal damage such as the production of reactive oxygen species (ROS), opening of the mitochondrial permeability transition pore (mPTP), and apoptosis. Therefore, interventions that aim to protect mitochondria may be effective against brain disorders. Fucoxanthin is a marine carotenoid that has recently gained recognition for its neuroprotective properties. However, the cellular mechanisms of fucoxanthin in brain disorders, particularly its role in mitochondrial function, have not been thoroughly discussed. This review summarises the current literature on the effects of fucoxanthin on oxidative stress, neuroinflammation, and apoptosis using in vitro and in vivo models of brain disorders. We further present the potential mechanisms by which fucoxanthin protects mitochondria, with the objective of developing dietary interventions for a spectrum of brain disorders. Although the studies reviewed are predominantly preclinical studies, they provide important insights into understanding the cellular and molecular functions of fucoxanthin in the brain. Future studies investigating the mechanisms of action and the molecular targets of fucoxanthin are warranted to develop translational approaches to brain disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cerebral Ischaemiamentioning

confidence: 95%