Widespread mafic volcanism, elevated crustal temperatures, and plateau‐type topography in Central Anatolia, Turkey, could collectively be the result of lithospheric delamination, mantle upwelling, and tectonic escape. We use results from 40Ar/39Ar geochronology, basalt geochemistry, and a passive‐source broadband seismic experiment obtained in a collaborative international effort (Continental Dynamics‐Central Anatolia Tectonics) to investigate the upper mantle structure and evolution of melting conditions over an ∼2400 km2 area south and west of Hasan volcano. New 40Ar/39Ar dates for the basalts mostly cluster between 0.2 and 0.6 Ma, but some scoria cones are as old as 2.5 Ma. Basalts are dominantly Mg‐rich (Mg# = 62–71), moderately alkaline (normative Ne < 5 wt %), and, based on major and trace element signatures, derived from a peridotitic source. Covariations between radiogenic isotope and trace element signatures reveal contributions from a subduction‐related component and intraplate‐like mantle asthenosphere, as well as from ambient upper mantle. Central Anatolian basalts reflect maximum mantle potential temperatures of <1350°C and an average pressure of melt equilibration of 1.4 GPa, which are cooler and shallower than for basalts from Eastern and Western Anatolia. When considered in light of regionally slow upper mantle shear wave velocities, the mantle lithosphere may be thin and infiltrated by melts, or largely absent. An absence of secular changes in melting conditions suggests little to no lithospheric thinning over the past ∼1 Ma, despite evidence for lithospheric extension. Hasan basalts appear to be generated by decompression melting in response to the rollback of the Cyprean slab.