The number of isotopic studies on Quaternary megafauna has increased over the last decades, yet, there is no published data addressing the status of scientific production of this research field. The present study shows the results of a bibliometric research carried out in the Scopus database where the publishing trends within this scientific field was analyzed using the open source software tool SciMAT. We retrieved 278 papers published from 1980 to 2019 and observed that a significant increase in publishing has mainly occurred in the last decade analyzed here. We also identified some of the field´s most influential articles and journals; recognized that carbon, oxygen and nitrogen isotopes are the most used markers in these studies; and that the most cited taxa are representatives of Equidae, Bovidae and Proboscidae. Also, Paleoecology is the basic thematic area, whereas Climate and Paleoenvironmental Changes is the one with the greatest development potential. Our results clearly show that the isotopic study on Quaternary megafauna is still under development and that some subjects could be further explored, such as analyzing more taxa within Carnivora, Pilosa, Notoungulata, Cetartiodactyla and Perissodactyla as well as using other less frequent stable isotope markers, such as strontium, calcium and hydrogen.