2017
DOI: 10.4236/ns.2017.99032
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pLoc-mGpos: Incorporate Key Gene Ontology Information into General PseAAC for Predicting Subcellular Localization of Gram-Positive Bacterial Proteins

Abstract: The basic unit in life is cell. It contains many protein molecules located at its different organelles. The growth and reproduction of a cell as well as most of its other biological functions are performed via these proteins. But proteins in different organelles or subcellular locations have different functions. Facing the avalanche of protein sequences generated in the postgenomic age, we are challenged to develop high throughput tools for identifying the subcellular localization of proteins based on their se… Show more

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Cited by 55 publications
(23 citation statements)
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References 121 publications
(198 reference statements)
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“…As we can see, based on the definition of Equations (11)- (14), the meanings of Sn, Sp, Acc and MCC have become much more intuitive and easier to understand, as concurred in a series of recent publications (see, e.g., [80,84,86,88,90,106,[108][109][110][111][112][113]). It is instructive to point out that the performance metrics as defined in Equations (7)- (10) or Equations (11)- (14) are valid only for single label systems; whereas for multi-label systems (see, e.g., [114][115][116][117]), a set of more complicated metrics should be used as discussed in [118].…”
Section: Performance Evaluationmentioning
confidence: 99%
“…As we can see, based on the definition of Equations (11)- (14), the meanings of Sn, Sp, Acc and MCC have become much more intuitive and easier to understand, as concurred in a series of recent publications (see, e.g., [80,84,86,88,90,106,[108][109][110][111][112][113]). It is instructive to point out that the performance metrics as defined in Equations (7)- (10) or Equations (11)- (14) are valid only for single label systems; whereas for multi-label systems (see, e.g., [114][115][116][117]), a set of more complicated metrics should be used as discussed in [118].…”
Section: Performance Evaluationmentioning
confidence: 99%
“…As stated in [ 85 ] and demonstrated in numerous studies [ 10 14 , 17 , 20 22 , 25 , 26 , 29 , 30 , 42 44 , 47 , 86 , 87 ], the availability of user-friendly web servers should be the next step in every computational predictor in order to enhance its impact [ 9 ]. To accomplish this, we will intend to build such a web server in the future so that the scientific community could significantly benefit from the proposed predictor.…”
Section: Resultsmentioning
confidence: 99%
“…In order to design an efficient sequence-based computational predictor for solving biological problems, a long list of studies [ 25 , 26 , 42 47 ] has made reference to a five-step rule [ 48 ]. This rule comprises the following steps: (1) the construction or selection of a correct dataset for training and testing a predictor, (2) the use of an accurate mathematical expression for transforming the biological sequence and considering the intrinsic correlation to future predictions, (3) the development of an exact algorithm for making predictions, (4) the proper use of statistical metrics for assessing the predictor accuracy, and (5) the design of a user-friendly server for making the predictor available to the public.…”
Section: Introductionmentioning
confidence: 99%
“…As pointed out in [124] and demonstrated in a series of recent publications (see, e.g., [40,[125][126][127][128][129][130][131][132][133][134][135][136][137][138][139][140][141][142][143][144]), user-friendly and publicly accessible web-servers represent the future direction for developing practically more useful prediction methods and computational tools. Actually, many practically useful web-servers have significantly increased the impacts of bioinformatics on medical science [29], driving medicinal chemistry into an unprecedented revolution [96].…”
Section: Discussionmentioning
confidence: 99%