Plocoralides A–C, polyhalogenated monoterpenes from the marine alga Plocamium corallorhiza

Knott, Michael G.; Mkwananzi, Henry; Arendse, Catherine E.; Hendricks, Denver T.; Bolton, John J.; Beukes, Denzil R.

doi:10.1016/j.phytochem.2005.03.029

Cited by 35 publications

(15 citation statements)

References 19 publications

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“…Anverene D ( 8 ) was obtained as a clear oil with spectral data similar to that of anverene C ( 7 ) and certain shifts bearing close resemblance to plocoralide B ( 11 ) (Scheme 4) [11]. A formula of C 10 H 15 Br 2 Cl 3 was established from HRNCIMS ([M − H] − : m/z 396.8535, calc.…”

Section: Resultsmentioning

confidence: 99%

Anverenes B–E, New Polyhalogenated Monoterpenes from the Antarctic Red Alga Plocamium cartilagineum

et al. 2019

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The subtidal red alga Plocamium cartilagineum was collected from the Western Antarctic Peninsula during the 2011 and 2017 austral summers. Bulk collections from specific sites corresponded to chemogroups identified by Young et al. in 2013. One of the chemogroups yielded several known acyclic halogenated monoterpenes (2–5) as well as undescribed compounds of the same class, anverenes B–D (6–8). Examination of another chemogroup yielded an undescribed cyclic halogenated monoterpene anverene E (9) as its major secondary metabolite. Elucidation of structures was achieved through one-dimensional (1D) and 2D nuclear magnetic resonance (NMR) spectroscopy and negative chemical ionization mass spectrometry. Compounds 1–9 show moderate cytotoxicity against cervical cancer (HeLa) cells.

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Section: Resultsmentioning

confidence: 99%

Anverenes B–E, New Polyhalogenated Monoterpenes from the Antarctic Red Alga Plocamium cartilagineum

et al. 2019

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“…Four halogenated monoterpenes isolated from Plocamium suhrii (Rhodophyta) exhibited greater cytotoxicity when compared to cisplatin, a known anticancer drug, when assayed against an esophageal cancer cell line [ 68 ]. Polyhalogenated monoterpenes from Plocamium corallorhiza (Rhodophyta) also showed moderate cytotoxicity towards esophageal cancer cells [ 69 ] Peyssonoic acids A–B and a novel sesquiterpene hydroquinnones isolated from Peyssonnelia sp. exhibited modest antiproliferative activity against ovarian cancer cells [ 70 ].…”

Section: Anticancer Activity Of Seaweed Componentsmentioning

confidence: 99%

Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases

et al. 2016

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Seaweeds are a large and diverse group of marine organisms that are commonly found in the maritime regions of the world. They are an excellent source of biologically active secondary metabolites and have been shown to exhibit a wide range of therapeutic properties, including anti-cancer, anti-oxidant, anti-inflammatory and anti-diabetic activities. Several Asian cultures have a strong tradition of using different varieties of seaweed extensively in cooking as well as in herbal medicines preparations. As such, seaweeds have been used to treat a wide variety of health conditions such as cancer, digestive problems, and renal disorders. Today, increasing numbers of people are adopting a “westernised lifestyle” characterised by low levels of physical exercise and excessive calorific and saturated fat intake. This has led to an increase in numbers of chronic Non-communicable diseases (NCDs) such as cancer, cardiovascular disease, and diabetes mellitus, being reported. Recently, NCDs have replaced communicable infectious diseases as the number one cause of human mortality. Current medical treatments for NCDs rely mainly on drugs that have been obtained from the terrestrial regions of the world, with the oceans and seas remaining largely an untapped reservoir for exploration. This review focuses on the potential of using seaweed derived bioactives including polysaccharides, antioxidants and fatty acids, amongst others, to treat chronic NCDs such as cancer, cardiovascular disease and diabetes mellitus.

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“…Plocaralides B 259 and C 260 isolated from Ploeamium species (Steierle et al, 1979;Higgs et al, 1977) and Aplysia ealiforniea (Ireland et al, 1976) displayed moderate activity against the human oesophageal cancer cell line WHCOI (Knott et al, 2005).…”

Section: Fivementioning

confidence: 99%

Biological importance of marine algae

Gamal

2010

Saudi Pharmaceutical Journal

405

166

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Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. Algae can be classified into two main groups; first one is the microalgae, which includes blue green algae, dinoflagellates, bacillariophyta (diatoms)… etc., and second one is macroalgae (seaweeds) which includes green, brown and red algae. The microalgae phyla have been recognized to provide chemical and pharmacological novelty and diversity. Moreover, microalgae are considered as the actual producers of some highly bioactive compounds found in marine resources. Red algae are considered as the most important source of many biologically active metabolites in comparison to other algal classes. Seaweeds are used for great number of application by man. The principal use of seaweeds as a source of human food and as a source of gums (phycocollides). Phycocolloides like agar agar, alginic acid and carrageenan are primarily constituents of brown and red algal cell walls and are widely used in industry.

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Plocoralides A–C, polyhalogenated monoterpenes from the marine alga Plocamium corallorhiza

Cited by 35 publications

References 19 publications

Anverenes B–E, New Polyhalogenated Monoterpenes from the Antarctic Red Alga Plocamium cartilagineum

Anverenes B–E, New Polyhalogenated Monoterpenes from the Antarctic Red Alga Plocamium cartilagineum

Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases

Biological importance of marine algae

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