Ploidy and histological types of mammary carcinomas

Tavares, Amândio S.

doi:10.1016/0014-2964(68)90081-9

Cited by 14 publications

(2 citation statements)

References 6 publications

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“…On the basis of microspectrophotometric measurements of the DNA content, RABOTTI (1959) first suggested a shift toward a higher level of ploidy in metastatic tumours. Using the same method, CHU and MALMGREN (1961) obtained similar results, whereas the results of MEEK (1961); STICH and STEELE (1962); INUI (1963); ATKIN et al (1966); TAVARES (1968); ZANK and KRUG (1970) and ATKIN (1970ATKIN ( , 1971 indicate that the level of ploidy of the primary neoplasm in general is repeated in the metastases. Changes in ploidy, when they occurred, were seen in both directions.…”

mentioning

confidence: 84%

Comparative chromosome analysis of primary and metastatic Rous sarcomas in rats

Mitelman

2009

Hereditas

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The chromosomes were studied in 16 metastatic Rous (RSV-SR) rat sarcomas. About 40 yo of the tumours had a normal diploid stemline and of these tumours about 70 % had 1 or 2 hyperdiploid sidelines. Among the heteroploid metastases, hyperdiploidy accounted for 2/3 and pseudodiploidy for 1 /3 of the stemlines. The chromosome variation in the development of the heteroploid stem-and sidelines was non-random and had the same characteristics as previously found in primary Rous rat sarcomas. There was a close karyotypic relation between the primary sarcomas and their metastases. The essential difference between them was an accelerated chromosomal progression in the secondary tumours. This progression was associated with a decrease in the histologic maturity of the tumours.

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mentioning

confidence: 84%

Comparative chromosome analysis of primary and metastatic Rous sarcomas in rats

Mitelman

2009

Hereditas

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“…It has been postulated that the prevalence of multiploidy between the ages of 40 and 60 is a possible reason for the well known refractoriness of recurrent breast cancer to endocrine treatment in perimenopausal women, as the probability of these tumours containing a hormonally insensitive subclone may be high. 88 An association between tumour ploidy and differentiation has been described, with well differentiated tumours tending to be diploid and poorly differentiated tumours aneuploid.87 98 It is possible that tumour ploidy may be an alternative to the currently used nuclear grading systems because it is objective and reproducible.…”

Section: Breast Cancermentioning

confidence: 99%

Clinical and biological significance of aneuploidy in human tumours.

Friedlander¹,

Hedley²,

Taylor³

1984

Journal of Clinical Pathology

390

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SUMMARY Aneuploidy is a well recognised feature of human tumours, but the investigation of its biological and clinical significance has been hampered by technological constraints. Quantitative DNA analysis reflects the total chromosomal content of tumour cells and can now be determined rapidly and reliably using flow cytometry; this has resulted in renewed interest in its potential clinical applications. This article reviews the accumulating evidence that tumour ploidy reflects the biological behaviour of a large number of tumour types and that diploid tumours in particular have a relatively good prognosis. The measurement of tumour ploidy is likely to become a valuable adjunct to the clinical and histopathological assessment of cancers.

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Nuclear DNA content of occult sclerosing and frank papillary carcinoma of the thyroid

Izuo¹,

Okagaki²,

Richart³

et al. 1971

Cancer

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The nuclear DNA content was measured in 6 cases of so‐called occult sclerosing papillary carcinoma of the thyroid, 5 cases of frank (clinically detectable) papillary carcinoma, and one borderline atypical papillary lesion. One hundred neoplastic cell nuclei were measured in each case. Most of the cases in both groups of papillary carcinoma had a nuclear DNA distribution with a stem‐line in the near‐diploid region. After correcting to normality by logarithmic transformation and adjusting for S‐phase cells, the “corrected computed modal values” in the majority of the cases were significantly hypodiploid. In 3 cases, correction for S phase cells was not applicable because the modes were not discrete. There was a widely spread aneuploid DNA distribution.

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Ploidy and histological types of mammary carcinomas

Cited by 14 publications

References 6 publications

Comparative chromosome analysis of primary and metastatic Rous sarcomas in rats

Comparative chromosome analysis of primary and metastatic Rous sarcomas in rats

Clinical and biological significance of aneuploidy in human tumours.

Nuclear DNA content of occult sclerosing and frank papillary carcinoma of the thyroid

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