Plug-in label-free optical fiber DNA hybridization sensor based on C-type fiber Vernier effect

Li, Fēi; Li, Xuegang; Zhou, Xue; Gong, Pengqi; Zhang, Yanan; Zhao, Yong; Nguyen, Linh V.; Ebendorff‐Heidepriem, Heike; Warren‐Smith, Stephen C.

doi:10.1016/j.snb.2021.131212

Cited by 41 publications

(12 citation statements)

References 41 publications

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“…The FSR of FPI1, FPI2, and FPI3 (12.94, 2.84, and 2.38 nm, respectively) computed using (4) agreed well with the results (12.96, 2.86, and 2.34 nm, respectively) achieved by filtering peak 1, peak 2, and peak 3, respectively, as shown in Fig. 3(c) [41]. The reflected spectrum of the OCFPI shown in Fig.…”

Section: B Experimental Setup and Working Principlesupporting

confidence: 83%

Ultrahigh Sensitivity Temperature Sensor Based on Harmonic Vernier Effect

Chen

Tian

et al. 2023

IEEE Sensors J.

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A high-sensitivity and miniature open cavity Fabry-Perot interferometer (OCFPI) encapsulated with the polydimethylsiloxane (PDMS) film based on high-order harmonic Vernier effect is designed and experimentally investigated. To the best of our knowledge, PDMS is applied for the first time to fill the open cavity of Fabry-Perot interferometer to obtain high-temperature sensitivity. The resonant dip (peak) wavelength of the designed temperature sensor monotonically moves toward the shortwave direction as the temperature increases from 40°C to 60°C due to the effects of expansion and thermo-optic property of PDMS. The proposed OCFPI encapsulated with PDMS film provides the following excellent performance advantages. (1) Compared with traditional all-fiber air-cavity OCFPIs with temperature sensitivity of approximately 10 pm/°C, the proposed OCFPI sensor has a much higher temperature sensitivity of −3.4 nm/°C at the temperature range of 40°C-60°C with a magnification factor (M-factor) of approximately 11 when order of harmonic Vernier effect i = 4. (2) The proposed OCFPI exhibits good reversibility during the heating and cooling processes, and the measured M-factor matches well with the theoretically calculated M-factor. (3) The proposed OCFPI shows excellent stability with maximum wavelength deviation of 0.567 nm (internal envelope based on a fourth-order harmonic Vernier effect) and 0.042 nm (upper envelope) within 450 min. (4) The proposed OCFPI is inexpensive, robust, easy to fabricate, and compact, which can be used in harsh environments. Therefore, it provides excellent potential in dynamic temperature measurement.

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Section: B Experimental Setup and Working Principlesupporting

confidence: 83%

Ultrahigh Sensitivity Temperature Sensor Based on Harmonic Vernier Effect

Chen

Tian

et al. 2023

IEEE Sensors J.

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“…However, these advanced sensors often face challenges related to their delicate structure and packaging difficulties. Furthermore, achieving high sensitivity through multiple interference effects, such as the Vernier effect, 30 introduces complexities in signal demodulation. In DNA biological solutions, the pronounced sensitivity to RI changes necessitates temperature control measures to ensure accuracy.…”

Section: Introductionmentioning

confidence: 99%

Rapid and quantitative detection of DNA hybridization using a simplified Fabry–Perot interferometric biosensor

Shi,

Ma,

Liao

et al. 2024

RSC Adv.

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“…Optical fiber sensors have recently gained more and more attention because of their ability to serve as label-free, real-time, highly sensitive, and rapidly responsive DNA hybridization sensors. Currently, various optical fiber sensors are available for in situ DNA hybridization detection, including optical fiber surface plasmon resonance (SPR) sensors [ 14 , 15 , 16 ], optical fiber gratings [ 11 , 17 , 18 ], and optical fiber interferometers [ 19 , 20 , 21 , 22 ]. Leung A et al reported on gold-coated tapered optical fiber sensors for DNA detection.…”

Section: Introductionmentioning

confidence: 99%

Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor

Wu,

Wang,

et al. 2024

Sensors

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A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields.

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Plug-in label-free optical fiber DNA hybridization sensor based on C-type fiber Vernier effect

Cited by 41 publications

References 41 publications

Ultrahigh Sensitivity Temperature Sensor Based on Harmonic Vernier Effect

Ultrahigh Sensitivity Temperature Sensor Based on Harmonic Vernier Effect

Rapid and quantitative detection of DNA hybridization using a simplified Fabry–Perot interferometric biosensor

Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor

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