Plugging the leak

Young, Timothy

doi:10.1007/s10286-003-0092-8

Cited by 12 publications

(1 citation statement)

References 17 publications

(19 reference statements)

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“…The pharmacological therapies and the possible mechanisms of their benefit are summarized in Table 2. 7-11 There were no adverse effects to the medications.…”

Section: Case Presentationmentioning

confidence: 98%

Renal Transplantation in Pure Autonomic Failure

Abideen

Rixon

Gunatillake

et al. 2022

Transplantation Direct

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Written informed consent was obtained from the patient for this case report. Z.U.A. was part of the MDT team who managed the patient in the in and outpatient setting. He conducted the literature review on the topic, coined the idea of writing the case report, drafted the article, critically reviewed it, and approved the final version for submission. A.R. conducted literature review, drafted the article, prepared the figures and tables, critically reviewed the article, and approved the final version before submission. N.D.G. was lead consultant who managed the patient's pretransplant out patient management. She helped in drafting the article, and critically reviewing it approving it for final submission. E.H. was heavily involved in managing the neurological condition of the patient both as an in and out patient and was part of the MDT team. She helped in drafting the article, critically reviewing it, and approving it for final submission.

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“…The pharmacological therapies and the possible mechanisms of their benefit are summarized in Table 2. 7-11 There were no adverse effects to the medications.…”

Section: Case Presentationmentioning

confidence: 98%

Renal Transplantation in Pure Autonomic Failure

Abideen

Rixon

Gunatillake

et al. 2022

Transplantation Direct

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Orthostatic Hypotension in Parkinson's Disease

Muthane¹

2011

Parkinson's Disease

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Dysautonomia in the Ehlers–Danlos syndromes and hypermobility spectrum disorders—With a focus on the postural tachycardia syndrome

Owens

Iodice

Hakim

2021

American J of Med Genetics Pt C

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Dysautonomia (autonomic dysfunction) occurs in the Ehlers-Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD). Symptoms include palpitations, dizziness, presyncope, and syncope, especially when standing upright. Symptoms of orthostatic intolerance are usually relieved by sitting or lying and may be exacerbated by stimuli in daily life that cause vasodilatation, such as food ingestion, exertion, and heat. Neurocardiovascular dysautonomia may result in postural tachycardia syndrome (PoTS), a major cause of orthostatic intolerance. It is defined by a rise in heart rate of >30 beats per minute (bpm) in adults and >40 bpm in teenagers while upright, without a fall in blood pressure (BP; orthostatic hypotension). In some, it can be compounded by the presence of low BP. For many, there is delay in clinicians recognizing the nature of the symptoms, and recognizing EDS or HSD, leading to delays in treatment. The onset of PoTS may be linked to an event such as infection, trauma, surgery, or stress. Gastrointestinal and urinary bladder involvement may occur, along with thermoregulatory dysfunction. In some, the mast cell activation syndrome may be contributary, especially if it causes vasodilatation. This paper reviews neurocardiovascular dysautonomia with an emphasis on PoTS, its characteristics, associations, pathophysiology, investigation, and treatment.

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Plugging the leak

Cited by 12 publications

References 17 publications

Renal Transplantation in Pure Autonomic Failure

Renal Transplantation in Pure Autonomic Failure

Orthostatic Hypotension in Parkinson's Disease

Dysautonomia in the Ehlers–Danlos syndromes and hypermobility spectrum disorders—With a focus on the postural tachycardia syndrome

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