Plumbagin‐silver nanoparticle formulations enhance the cellular uptake of plumbagin and its antiproliferative activities

Appadurai, Prakash; Rathinasamy, Krishnan

doi:10.1049/iet-nbt.2015.0008

Cited by 26 publications

(9 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result correlated well with those obtained from the antiproliferative assay, showing that Tf‐bearing liposomes exhibited the highest antiproliferative effect on B16‐F10 cells followed by A431 and T98G cells. Our results were in agreement with previous reports which demonstrated that the treatment with plumbagin entrapped in silver nanocages led to the apoptosis of A431 cells (Duraipandy et al, ) and HeLa cells (Appadurai & Rathinasamy, ), unlike free plumbagin.…”

Section: Discussionsupporting

confidence: 94%

Transferrin‐bearing liposomes entrapping plumbagin for targeted cancer therapy

Sakpakdeejaroen

Somani

Laskar

et al. 2019

J of Interdiscip Nanomed

View full text Add to dashboard Cite

The therapeutic potential of plumbagin, a naphthoquinone extracted from the officinal leadwort with anticancer properties, is hampered by its failure to specifically reach tumours at a therapeutic concentration after intravenous administration, without secondary effects on normal tissues. Its use in clinic is further limited by its poor aqueous solubility, its spontaneous sublimation, and its rapid elimination in vivo . We hypothesize that the entrapment of plumbagin within liposomes grafted with transferrin, whose receptors are overexpressed on many cancer cells, could result in a selective delivery to tumours after intravenous administration. The objectives of this study were therefore to prepare and characterize transferrin‐targeted liposomes entrapping plumbagin and to evaluate their therapeutic efficacy in vitro and in vivo . The entrapment of plumbagin in transferrin‐bearing liposomes led to an increase in plumbagin uptake by cancer cells and improved antiproliferative efficacy and apoptosis activity in B16‐F10, A431, and T98G cell lines compared with that observed with the drug solution. In vivo, the intravenous injection of transferrin‐bearing liposomes entrapping plumbagin led to tumour suppression for 10% of B16‐F10 tumours and tumour regression for a further 10% of the tumours. By contrast, all the tumours treated with plumbagin solution or left untreated were progressive. The animals did not show any signs of toxicity. Transferrin‐bearing liposomes entrapping plumbagin are therefore highly promising therapeutic systems that should be further optimized as a therapeutic tool for cancer treatment.

show abstract

Section: Discussionsupporting

confidence: 94%

Transferrin‐bearing liposomes entrapping plumbagin for targeted cancer therapy

Sakpakdeejaroen

Somani

Laskar

et al. 2019

J of Interdiscip Nanomed

View full text Add to dashboard Cite

show abstract

“…The application of plumbagin in cancer therapy has been limited due to its low aqueous solubility and the side‐effects. Nano‐drug delivery systems and other pharmaceutic strategies may encapsulate plumbagin effectively to overcome poor water solubility, prolong circulation half‐life time, reduce the side‐effects, and ameliorate the anticancer efficacy . Also, a great amount of efforts have been dedicated to the development of plumbagin derivatives for the purpose of improving molecular properties and pharmacological profile .…”

Section: Miscellaneousmentioning

confidence: 99%

“…systems and other pharmaceutic strategies may encapsulate plumbagin effectively to overcome poor water solubility, prolong circulation half-life time, reduce the side-effects, and ameliorate the anticancer efficacy. [68][69][70] Also, a great amount of efforts have been dedicated to the development of plumbagin derivatives for the purpose of improving molecular properties and pharmacological profile. [71] Shikonin is another plant-based secondary metabolite belonging to 1,4-naphthoquinone and is extracted from the root of Lithospermum erythrorhizon.…”

Section: Miscellaneousmentioning

confidence: 99%

Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents

et al. 2017

View full text Add to dashboard Cite

Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been implicated with human life since ancient time, far earlier than their isolation and identification in modern era. The long use history of naphthoquinones has witnessed their functional shift from the original purposes as dyes and ornaments toward medicinal benefits. Hitherto, numerous studies have been carried out to elucidate the pharmacological profile of both natural and artificial naphthoquinones. A number of entities have been identified with promising therapeutic potential. Apart from the traditional effects of wound healing, anti-inflammatory, hemostatic, antifertility, insecticidal and antimicrobial, etc., the anticancer potential of naphthoquinones either in combination with other treatment approaches or on their own is being more and more realized. The molecular mechanisms of naphthoquinones in cells mainly fall into two categories as inducing oxidant stress by ROS (reactive oxygen species) generation and directly interacting with traditional therapeutic targets in a non-oxidant mechanism. Based on this knowledge, optimized agents with naphthoquinones scaffold have been acquired and further tested. Hereby, we summarize the explored biological mechanisms of naphthoquinones in cells and review the application perspective of promising naphthoquinones in cancer therapies.

show abstract

“…For the phytochemical plumbagin, silver nanoparticles were synthesized to overcome the lack of sensitivity and selectivity towards cancer cells, and such formulation reduced the effective concentration required to induce apoptosis to half of the free compound [ 204 ] in addition to enhancing the cellular uptake [ 205 ]. The reduced toxicity in normal cells, and better bioavailability of nanoformulated plumbagin has been reported by another independent group as well [ 206 ].…”

Section: Challenges For Phytochemicals In Cancer Therapy and Emergmentioning

confidence: 99%

Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch

et al. 2017

View full text Add to dashboard Cite

Phytochemicals are an important part of traditional medicine and have been investigated in detail for possible inclusion in modern medicine as well. These compounds often serve as the backbone for the synthesis of novel therapeutic agents. For many years, phytochemicals have demonstrated encouraging activity against various human cancer models in pre-clinical assays. Here, we discuss select phytochemicals—curcumin, epigallocatechin-3-gallate (EGCG), resveratrol, plumbagin and honokiol—in the context of their reported effects on the processes of inflammation and oxidative stress, which play a key role in tumorigenesis. We also discuss the emerging evidence on modulation of tumor microenvironment by these phytochemicals which can possibly define their cancer-specific action. Finally, we provide recent updates on how low bioavailability, a major concern with phytochemicals, is being circumvented and the general efficacy being improved, by synthesis of novel chemical analogs and nanoformulations.

show abstract

Plumbagin‐silver nanoparticle formulations enhance the cellular uptake of plumbagin and its antiproliferative activities

Cited by 26 publications

References 45 publications

Transferrin‐bearing liposomes entrapping plumbagin for targeted cancer therapy

Transferrin‐bearing liposomes entrapping plumbagin for targeted cancer therapy

Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents

Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch

Contact Info

Product

Resources

About