Plumieride from<i>Allamanda cathartica</i>as an inhibitory compound to plant pathogenic fungi

Mone, M.; Saieed, M.A.U.; Dastogeer, Khondoker M. G.; Ali, M.A.; Meah, M. B.

doi:10.1080/03235408.2013.840103

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…Also, it demonstrated antifungal activity against dermatophytes and phytopathogens, and immunostimulatory activities [ 41 – 44 ]. Furthermore, plumieride inhibited the radial mycelial growth of Phomopsis vexans, Phytophthora capsici, Fusarium oxysporum, Rhizoctonia solani , and Sclerotium rolfsii in vitro [ 43 ]. It has been suggested that the antimicrobial properties of Plumeria flowers can be attributed to the presence of various phytochemical compounds with anti-inflammatory, anti-quorum sensing, and antioxidant properties [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Plumieride as a novel anti-fungal and anti-inflammatory iridoid against superficial candidiasis in mice

El-Shiekh,

Meselhy,

Elshimy

et al. 2024

BMC Complement Med Ther

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In the past few decades, there has been a notable rise in the occurrence of several types of candidiasis. Candida albicans is the most common cause of superficial fungal infections in humans. In this study, plumieride, one of the major iridoids from Plumeria obtusa L. leaves, was isolated and investigated for its potential against Candida albicans (CA)-induced dermatitis in mice. qRT-PCR was done to assess the impact of plumieride on the expression of the major virulence genes of CA. Five groups (n = 7) of adult male BALB/c mice were categorized into: group I: non-infected mice; group II: mice infected intradermally with 107–108 CFU/mL of CA; group III: CA-infected mice treated with standard fluconazole (50 mg/kg bwt.); group IV and V: CA-infected mice treated with plumieride (25- and 50 mg/kg. bwt., respectively). All the treatments were subcutaneously injected once a day for 3 days. Skin samples were collected on the 4th day post-inoculation to perform pathological, microbial, and molecular studies. The results of the in vitro study proved that plumieride has better antifungal activity than fluconazole, manifested by a wider zone of inhibition and a lower MIC. Plumieride also downregulated the expression of CA virulence genes (ALS1, Plb1, and Hyr1). CA-infected mice showed extensive dermatitis, confirmed by strong iNOS, TNF-α, IL-1β, and NF-κB genes or immune expressions. Whereas the treatment of CA-infected mice with plumieride significantly reduced the microscopic skin lesions and modulated the expression of all measured proinflammatory cytokines and inflammatory markers in a dose-dependent manner. Plumieride interfered with the expression of C. albicans virulence factors and modulated the inflammatory response in the skin of mice infected with CA.

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Section: Discussionmentioning

confidence: 99%

Plumieride as a novel anti-fungal and anti-inflammatory iridoid against superficial candidiasis in mice

El-Shiekh,

Meselhy,

Elshimy

et al. 2024

BMC Complement Med Ther

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“…[ 43–46 ] Plumieridine can be obtained by enzymatic hydrolysis of plumieride, as previously described. [ 17 ] Several biological activities of plumieride have been described: such as antifungal against dermatophytes [ 47,48 ] and phytopathogens, [ 49 ] antidepressant‐like, [ 50 ] and immunostimulatory activities. [ 51 ] The MIC and MFC values of plumieride and plumieridine were higher than the MIC values of ASEAP, with the exception of MFC of plumieridine for C. neoformans H99.…”

Section: Discussionmentioning

confidence: 99%

Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp.

Bresciani

Santi

Beys‐da‐Silva

et al. 2020

Archiv der Pharmazie

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Cryptococcosis, caused by Cryptococcus spp., is an invasive fungal infection of the central nervous system, associated with high mortality, affecting mainly immunocompromised patients. Due to the development of resistance to the current therapy, there is an urgent need for less toxic and more effective antifungal agents. In this study, we describe the antifungal activity against Cryptococcus spp. of an aqueous seed extract from Allamanda polyantha (ASEAP) and two iridoids, plumieride and plumieridine, isolated from this extract with an antifungal activity. The capsule formation and the morphological alterations were evaluated using fluorescent microscopy. The cytotoxic activity was also investigated. The minimal inhibitory concentration (MIC) values of ASEAP for Cryptococcus gattii were 70 and 36 µg/ml (for the R265 and R272 strains, respectively) and 563 µg/ml for Cryptococcus neoformans H99. ASEAP inhibited C. neoformans H99 capsule formation, an important virulence factor, and decreased the cell body size for both the C. gattii strains. H99 cells also presented morphological alterations, with defects in bud detachment and nuclear fragmentation. Plumieride and plumieridine presented higher MIC values than ASEAP, indicating that other compounds might contribute to antifungal activity and/or that combination of the compounds results in a higher antifungal activity.

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“…Many plant and plant extracts have been reported to have antimicrobial properties against plant pathogenic fungi (Sharmin et al, 2013;Vergnes, 2014;Akladious et al, 2015;Santos et al, 2015). Allamanda species extract has been proved as effective in controlling plant pathogenic fungi (Islam, 2004;Ravikumar et al, 2013;Basar et al, 2011;Mone et al, 2013;Barros et al, 2015;Brito et al, 2018). However, there is a small report available in the studies on detailed analyzes of leaf extract and its antifungal activity against plant pathogens.…”

Section: Discussionmentioning

confidence: 99%

Extracts From Leaves of Allamanda blanchetti Inducing Mechanism of Defense to Diseases in Sugarcane

Oliveira¹,

Almeida²,

Silva³

et al. 2019

JAS

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This research aims to analyze the effect of the extract from a native plant from Caatinga, Allamanda blanchetti, in the induction of resistance mechanisms in a sugarcane variety smut-susceptible. Initially, it carried out a phytochemical analysis to know the main plant compounds used in this study. Diverse chemicals content in ethanolic extract from A. blanchetii were detected by thin-layer chromatography (TLC). Flavonoids, were more abundant compounds following by terpenes, stereroids and saponins. Under greenhouse conditions the sugarcane plants, SP-791011 (smut-susceptible), were sprayed with extracts from A. blanchetti extracted at cold at concentrations of 1000 ppm and acilbenzolar-S-metil (ASM) (100 mg/L). Leaves were collected at 0, 24 and 48 hours after spraying and used in the RT-PCR analysis for to identify the defense gene expression. Change in gene expression were observed in the different treatments, especially in the expression of pathogenesis-related (PR) genes. The extract of A. blanchetti induced an increase in the glucanase expression and was more effective than ASM inducer. SNPR1 gene show increased in the two treatment. The results indicate that A. blanchetti extracts was able to activate the resistance mechanism as observed in resistant plants. This paper is the first report about the use of Caatinga natural plant extracts inducing resistance genes against Sporisorium scitamineum in sugarcane susceptible genotype.

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Plumieride fromAllamanda catharticaas an inhibitory compound to plant pathogenic fungi

Cited by 7 publications

References 10 publications

Plumieride as a novel anti-fungal and anti-inflammatory iridoid against superficial candidiasis in mice

Plumieride as a novel anti-fungal and anti-inflammatory iridoid against superficial candidiasis in mice

Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp.

Extracts From Leaves of Allamanda blanchetti Inducing Mechanism of Defense to Diseases in Sugarcane

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