Plummer Vinson syndrome association with coeliac disease

Hefaiedh, Rania; Boutreaa, Yosra; Ouakaa-Kchaou, Asma; Kochlef, Asma; Elloumi, Héla; Gargouri, Dalila; Kharrat, Jamel; Ghorbel, Abdeljabbar

doi:10.1016/j.ajg.2013.10.003

Cited by 7 publications

(8 citation statements)

References 7 publications

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“…The exact cause of esophageal web is not known; it can be associated with iron deficiency, autoimmune disease, or can be idiopathic. The overall incidence of PVS has decreased over the years due to improved nutritional status; however, it is still seen in developing countries 8–10 . The office of the rare diseases of the National Institutes of Health (NIH) has listed the Plummer–Vinson syndrome as a rare disease in the USA 11 .…”

Section: Introductionmentioning

confidence: 99%

Plummer–Vinson syndrome: A decade's experience of 132 cases from a single center

Patil

Malipatel

Devarbhavi

2020

J of Gastro and Hepatol

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Background and AimPlummer–Vinson syndrome (PVS) comprises triad of iron deficiency anemia, dysphagia, and post‐cricoid esophageal web. PVS is rare nowadays due to improved nutritional status. However, we encountered patients with PVS regularly at our center. Data regarding PVS are limited; hence, we aimed to study the clinical features, treatment outcomes, and development of complications in patients with PVS.MethodsThe study was conducted over a 10‐year period (January 2008 to January 2018) in a medical college setting. All adults with dysphagia, anemia, and post‐cricoid web or those with iron deficiency anemia and post‐cricoids web were included in the study. Patients were treated with iron supplementation and Savary–Gilliard bougie dilation of the web. Patients were followed‐up for the recurrence of dysphagia and development of complications.ResultsOverall, 153 patients exhibited esophageal web, of which 132 (86.27%) patients had concomitant PVS and 21 (13.7%) patients did not. The mean age was 43.50 years (range 16–76) and 113 (85.6%) were women. Single session of Savary–Gilliard bougie dilation was successful in 90.7% of patients in relieving dysphagia and 9.3% developed recurrence, requiring repeated dilations. Four patients had concomitant squamous cell carcinoma of esophagus along with PVS and two developed upper gastrointestinal malignancy during follow‐up.ConclusionPlummer–Vinson syndrome is predominantly seen in middle aged women and present with symptoms of iron deficiency anemia and early grade dysphagia. Single session of Savary–Gilliard bougie dilation was successful in majority of patients in relieving dysphagia. Overall risk of developing upper gastrointestinal malignancy was 4.5%.

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Section: Introductionmentioning

confidence: 99%

Plummer–Vinson syndrome: A decade's experience of 132 cases from a single center

Patil

Malipatel

Devarbhavi

2020

J of Gastro and Hepatol

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“…However, the incidence of PVs has decreased during the last decades probably as the consequence of largely available iron-replacement therapy. [23][24][25] Esophageal webs can also be rarely associated with celiac disease, 6,7 where iron-deficiency is usually the cause of anemia, dermatological conditions [8][9][10] or graftversus-host-disease. 11,12 It should be noted that dysphagia associated with iron-deficiency anemia is not always due to PVs.…”

Section: Discussionmentioning

confidence: 99%

<p>Idiopathic Cervical Esophageal Webs: A Case Report and Literature Review</p>

Petrea¹,

Stanciu²,

Muzîca³

et al. 2020

IJGM

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“…Case reports of celiac disease patients presenting with Plummer-Vinson syndrome are present in the literature [15-18]. In a study evaluating the association between cervical esophageal webs and celiac disease including 21 dysphagia and esophageal web patients, IDA was identified in 18 of the patients, while five patients were diagnosed with celiac disease by tissue transglutaminase activity and duodenal biopsy results.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Esophageal Functions by Manometry in Iron Deficiency Anemia Patients

2017

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BackgroundThe aim of this study was to investigate whether any esophageal motor dysfunction exists in patients with iron deficiency anemia (IDA).MethodsThe study included 39 patients (34 women, mean age: 44.17 ± 14.21 years) who met WHO diagnostic criteria for IDA. An additional 30 functional dyspepsia patients were also included as a control group. Esophageal motility testing was performed; esophagus contraction amplitude, peak velocity, contraction time, lower esophageal sphincter (LES) resting pressure, LES relaxation, and LES relaxation duration were assessed.ResultsA majority (76.4%) of patients had at least one IDA symptom, such as reflux, chest pain, or dysphagia. Manometric findings in IDA patients vs. controls were as follows: mean LES resting pressure (mm Hg): 25.41 ± 11.67 vs. 19.96 ± 6.58 (P = 0.025); mean esophageal contraction amplitude (mm Hg): 61.61 ± 24.21 vs. 63.23 ± 18.86 (P = 0.764); mean LES relaxation duration (s, x ± SD): 5.33 ± 1.61 vs. 8.75 ± 1.86 (P = 0.000); mean LES relaxation (%): 93.30 ± 9.88 vs. 95.53 ± 5.81 (P = 0.278); mean peak velocity (cm/s): 12.67 ± 37.95 vs. 3.50 ± 1.63 (P = 0.191). Esophageal dysmotility was found in 11 (28.2%) IDA patients. Non-specific esophageal motor disorder was found in three patients, hypomotility of the esophagus was found in three patients, achalasia was found in two patients, hypertensive LES was found in two patients, and hypotensive LES was found in one patient.ConclusionLES resting pressure was higher and LES relaxation duration was shorter in patients with IDA. Esophageal dysmotility was present in 28.2% of the patients with IDA A little more than half of patients had dysphagia symptoms. IDA may contribute to esophageal motility dysfunction and esophageal symptoms.

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Plummer Vinson syndrome association with coeliac disease

Cited by 7 publications

References 7 publications

Plummer–Vinson syndrome: A decade's experience of 132 cases from a single center

Plummer–Vinson syndrome: A decade's experience of 132 cases from a single center

<p>Idiopathic Cervical Esophageal Webs: A Case Report and Literature Review</p>

Evaluation of Esophageal Functions by Manometry in Iron Deficiency Anemia Patients

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