Plummer‐Vinson Syndrome in Children

Butori, Mathilde; Mahmoudi, Sana; Dugelay-Ecochard, Emmanuelle; Belarbi, Nadia; Bellaïche, M.; Hugot, Jean‐Pierre; Viala, Jérôme

doi:10.1097/mpg.0000000000000842

Cited by 11 publications

(14 citation statements)

References 34 publications

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“… 6 , 14 , 50 PVS has also rarely been reported in children and adolescents. 12 , 13 , 51 The average age of patients with post-cricoid carcinoma is about 15 years older than that of patients with PVS. 52 Whites appear to be affected more often than the black population groups.…”

Section: Clinical Featuresmentioning

confidence: 99%

Iron deficiency anemia and Plummer–Vinson syndrome: current insights

Goel¹,

Bakshi²,

Soni³

et al. 2017

JBM

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Plummer–Vinson syndrome (PVS), a rare clinical condition, is characterized by a triad of dysphagia, iron deficiency anemia and esophageal web in the post-cricoid region. It was first described over a century ago. However, literature on this condition remains scanty, and its prevalence appears to be declining worldwide, possibly due to improvements in nutrition over time. The condition has been reported most commonly in thin-built, middle-aged, white women. The esophageal webs in PVS are thin mucosal folds, which are best seen either in lateral views at barium swallow or at esophagoscopy. These are usually semilunar or crescentic, being located most often along the anterior esophageal wall, but can be concentric. The exact cause and pathogenesis of PVS remain unclear, though iron and other nutritional deficiencies, genetic predisposition and autoimmunity have all been implicated in formation of the webs. Treatment includes correction of iron deficiency and endoscopic dilation of the esophageal webs to relieve dysphagia. PVS is associated with an increased risk of hypopharyngeal and esophageal malignancies. Correction of iron deficiency may arrest and reverse the mucosal changes and possibly reduces this risk.

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Section: Clinical Featuresmentioning

confidence: 99%

Iron deficiency anemia and Plummer–Vinson syndrome: current insights

Goel¹,

Bakshi²,

Soni³

et al. 2017

JBM

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“…Plummer Vinson syndrome (PVS), also called Brown-Kelly, Paterson syndrome or "sideropenic dysphagia" is defined by an acquired dysphagia due to web or webs in the post cricoid oesophagus associated to an iron deficiency [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…It is a rare entity that affects especially females from white race around the third and the fifth decades [3]. Before that age, PVS is uncommon [1]. Few cases of PVS in pediatric population were reported in literature [1].…”

Section: Introductionmentioning

confidence: 99%

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Plummer Vinson Syndrome: First Two Tunisian Pediatric Cases

Werdani

2021

OAJBS

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Background: Plummer Vinson syndrome is a rare cause of dysphagia in children. It associates an oesophageal organic stenosis to a sideropenic anemia.Case Reports: Two Tunisian boys aged respectively 14 and 9 years-old were admitted to investigate dysphagia for solid foods. The adolescent patient was a black and he suffers from food blocking since 2 years ago. The assessment revealed a sideropenic anemia due to intestinal giardiasis. While the second patient was followed for a chronic anemia since he was 3 years old. For both of them, the swallow barium exploration showed an annular stenosis of the cervical esophagus mimicking "a thread knotted on a round tube" related to a circular web identified by fibroscopy. The iron supplementation and dilatation by the esophagoscope allowed the resolution of the clinical signs. Conclusion:Plummer Vinson syndrome exists in paediatric population. It should be evoked in any children presenting with upper dysphagia for solid foods in order to initiate iron supplementation and to watch for cancerous degeneration by regular followup.

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“…It mainly affects white women in their 40s-70s, but pediatric cases have been described. 1 This condition is mainly reported in the Indian subcontinent probably owing to nutrition limitation, although there may be genetic predisposition. 2 The pathophysiology of Plummer-Vinson syndrome remains unknown, but the esophageal web is thought to be a consequence of severe iron deficiency leading to a gastrointestinal tract's cell degeneration owing to the loss of iron-dependent enzymes.…”

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confidence: 99%

A Severe But Easily Treatable Dysphagia

2017

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Question: A 31-year-old woman, born in Pakistan, presented with dysphagia and severe anemia. She had a 10-year history of iron deficiency anemia secondary to chronic menorrhagia. She initially received a red blood cell transfusion, but had no gynecologic explorations or follow-up. The patient complained of dysphagia for solids that had been worsening for the last 5 years associated with a weight loss of 10 kg, but not with odynophagia or dysphonia. At admission, her hemoglobin level was 55 g/L, with a low mean corpuscular volume ( 70fL) and ferritin level (<10 mg/L). Oral clinical examination, nasopharyngeal endoscopy and cervical computed tomography scan were normal. A barium swallow (Figure A, B) and gastroscopy (Figure C) were performed.What is the diagnosis? See the Gastroenterology web site (www.gastrojournal.org) for more information on submitting your favorite image to Clinical Challenges and Images in GI.

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Plummer‐Vinson Syndrome in Children

Abstract: In the case of dysphagia in children, a swallow barium exploration with lateral incidence should look for PVS. Conversely to adults, an endoscopic dilation is frequently necessary to control dysphagia in children.

Cited by 11 publications

References 34 publications

Iron deficiency anemia and Plummer–Vinson syndrome: current insights

Iron deficiency anemia and Plummer–Vinson syndrome: current insights

Plummer Vinson Syndrome: First Two Tunisian Pediatric Cases

A Severe But Easily Treatable Dysphagia

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Plummer‐Vinson Syndrome in Children

Abstract: In the case of dysphagia in children, a swallow barium exploration with lateral incidence should look for PVS. Conversely to adults, an endoscopic dilation is frequently necessary to control dysphagia in children.

Cited by 11 publications

References 34 publications

Iron deficiency anemia and Plummer&ndash;Vinson syndrome: current insights

Iron deficiency anemia and Plummer&ndash;Vinson syndrome: current insights

Plummer Vinson Syndrome: First Two Tunisian Pediatric Cases

A Severe But Easily Treatable Dysphagia

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Product

Resources

About

Iron deficiency anemia and Plummer–Vinson syndrome: current insights

Iron deficiency anemia and Plummer–Vinson syndrome: current insights