Pluripotent Stem Cells in Research and Treatment of Hemoglobinopathies

Arora, Natasha; Daley, George Q.

doi:10.1101/cshperspect.a011841

Cited by 11 publications

(32 citation statements)

References 88 publications

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“…The advent of induced pluripotent stem (iPS) cells raises prospects for production of patient-specific erythrocytes for transfusion purposes. However, at present, it is prohibitively expensive and a daunting task to generate the vast numbers of cells required for clinical practice (Douay and Andreu 2007; see also Arora and Daley 2012).…”

Section: Erythroid Differentiation Within the Adult Hematopoietic Hiementioning

confidence: 99%

Erythropoiesis: Development and Differentiation

Dzierzak

Philipsen

2013

Cold Spring Harbor Perspectives in Medicine

301

278

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Section: Erythroid Differentiation Within the Adult Hematopoietic Hiementioning

confidence: 99%

Erythropoiesis: Development and Differentiation

Dzierzak

Philipsen

2013

Cold Spring Harbor Perspectives in Medicine

301

278

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“…HPSCs represent an attractive approach to generate any genetically matched tissue type (2). However, with unlimited potential, HPSCs are the furthest developmentally from differentiated tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, HPSC self-renewal and triggering of gastrulationlike differentiation requires different culture and microenvironmental conditions (2). Therefore, the development of hydrogel systems that allow the modification of the structural and adhesive microenvironment after the initial cross-linking would be ideal to control cell behavior (16)(17)(18).…”

Section: E8942 | Wwwpnasorgmentioning

confidence: 99%

“…The ability to couple expansion and differentiation of these cells underpins current efforts in regenerative medicine (2,3). Initial efforts to direct the fate of HPSCs by recapitulating the developmental process of gastrulation [by using spontaneous differentiation of embryoid bodies (EBs)] have been refined to allow directed differentiation in two and three dimensions (3D) (4).…”

Section: E8942 | Wwwpnasorgmentioning

confidence: 99%

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Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation

Dixon¹,

Shah²,

Rogers³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance Stem-cell microenvironment has been identified as an important modulator of plasticity, self-renewal, and differentiation. This work details the development of a hydrogel system tailored to promote human pluripotent stem cell (HPSC) self-renewal with a simple chemical microenvironmental switch to direct differentiation. Furthermore, the timing of switching post hydrogel fabrication can promote specific lineage differentiation as in vivo. This system highlights the role of microenvironment on fate choices of pluripotent cells and demonstrates that it may be tailored to control differentiation in vitro. Importantly, this approach may improve the generation of fully differentiated tissues, as demonstrated for cardiogenic differentiation. Our combination of hydrogels allows dense tissue structures to be produced from HPSCs by using a single-step process inaccessible to any current methodology.

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“…Recent developments in more radical forms of treatment for the thalassemias-notably bone marrow transplantation, gene therapy, and stem cell therapy-have been reviewed elsewhere (Daley 2012;Lucarelli and Tisdale 2012;Nienhuis and Persons 2012).…”

Section: General Principles Of the Management Of Thalassemiasmentioning

confidence: 99%

Management of the Thalassemias

Olivieri

Brittenham

2013

Cold Spring Harbor Perspectives in Medicine

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During the last 30 years, in addition to the considerable progress made in control and prevention of thalassemias 3 , there have also been major advances in their symptomatic management, at least in wealthier countries where appropriate facilities are available. Remarkable improvements in survival in the severe forms of thalassemia have followed the more judicious use of blood transfusion and, in particular, the ability to manage the iron accumulation resulting from transfusion with its severe and ultimately lethal effects on endocrine and cardiac function.

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Pluripotent Stem Cells in Research and Treatment of Hemoglobinopathies

Cited by 11 publications

References 88 publications

Erythropoiesis: Development and Differentiation

Erythropoiesis: Development and Differentiation

Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation

Management of the Thalassemias

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