Pluronic F-68 and F-127 Based Nanomedicines for Advancing Combination Cancer Therapy

Abstract

Pluronics are amphiphilic triblock copolymers composed of two hydrophilic poly (ethylene oxide) (PEO) chains linked via a central hydrophobic polypropylene oxide (PPO). Owing to their low molecular weight polymer and greater number of PEO segments, Pluronics induce micelle formation and gelation at critical micelle concentrations and temperatures. Pluronics F-68 and F-127 are the only United States (U.S.) FDA-approved classes of Pluronics and have been extensively used as materials for living bodies. Owing to the fascinating characteristics of Pluronics, many studies have suggested their role in biomedical applications, such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. As a result, various studies have been performed using Pluronics as a tool in nanomedicine and targeted delivery systems. This review sought to describe the delivery of therapeutic cargos using Pluronic F-68 and F-127-based cancer nanomedicines and their composites for combination therapy.

An Oral Nanomedicine Elicits In Situ Vaccination Effect against Colorectal Cancer

“…The nanomedicines in the current study contained three compositions, namely silk fibroin, p 127 , and tea leaf lipids. It is known that silk fibroin and p 127 are FDA-approved ingredients for medical applications, which can be purchased from pharmaceutical companies at low prices. , Tea leaf is a bioactive part of tea trees with the homology of medicine and food, and it contains abundant lipids (3–4% of dry weight) . Therefore, these three compositions are readily available for massive production of NPs.…”

Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

“…The last digit, 7, multiplied by 10, represents the weight fraction of PEO in each F127 molecule, approximately 70%. 88,98 Other members of the Pluronic series include Pluronic F68 99 and Pluronic F108, 100 each corresponding to different molecular weights of PPO and varying PEO contents. Pluronics offer simple synthesis, controllable performance, and easily adjustable structures.…”

Digital Light Processing 4D Printing of Poloxamer Micelles for Facile Fabrication of Multifunctional Biocompatible Hydrogels as Tailored Wearable Sensors

“…34 In addition, there are a limited number of studies reporting the physicochemical and biological properties of F-68-based hydrogels. 40 The terminal hydroxyl groups of the F-127 polymer can be functionalized, and photocured hydrogels have been prepared using the F-127 diacrylate polymer. 41 However, based on our knowledge, the amphiphilic photoreactive polymer has never been used in DLP 3D printing.…”

“…Another FDA-approved poloxamer, F-68, has a much higher critical micelle concentration of 0.4%, which means it is not as stable as F-127 micelles . In addition, there are a limited number of studies reporting the physicochemical and biological properties of F-68-based hydrogels . The terminal hydroxyl groups of the F-127 polymer can be functionalized, and photocured hydrogels have been prepared using the F-127 diacrylate polymer .…”