Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development

Shriky, Bana; Kelly, Adrian L.; Isreb, Mohammad; Babenko, Maksims; Mahmoudi, Najet; Rogers, Sarah E.; Shebanova, Olga; Snow, Tim; Gough, Tim

doi:10.1016/j.jcis.2019.12.096

Cited by 186 publications

(126 citation statements)

References 29 publications

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“…for Pluronic® F127 are in a good agreement with previously reported values for similar systems. [50][51][52][53][54] As previously stated, the gelation process is scarcely endothermic (i.e. almost athermal), and thus it has only been observed as a spike on the main peak at concentrations higher than the ones in the present study.…”

Section: Design and Thermal Properties In-house Synthesised Polymersupporting

confidence: 61%

“…1c), is of main importance. As extensively reported in the literature, [47][48][49][50] and shown in Fig. 1c) (left panel), the C gel of Pluronic® F127 is 15 w/w%, and it forms gels at room temperature at 20 w/w% and 25 w/w%, which makes handling of the samples challenging, as previously discussed.…”

Section: Design and Thermal Properties In-house Synthesised Polymersupporting

confidence: 56%

“…the phase separation, of polymer solutions. [50][51][52][53][54][55][56] Therefore, we employed DSC to record the changes in the thermal behaviour of the polymer solutions at 15 w/w% in PBS (C gel for Pluronic® F127), and the results are presented in Fig.2; the repeated thermograms can be found in Fig. S5.…”

Section: Design and Thermal Properties In-house Synthesised Polymermentioning

confidence: 99%

“…3 d), S9 and S10, are in a good agreement with the ones previously reported in the literature for concentrated solutions of the same polymer. 50,[64][65][66][67] We used the IGOR software to t the scattering, as it was found to capture the scattering features/peaks best. From the SANS analysis, we observed the presence of globular structures, as indicated by the tted power low value (P~3).…”

Section: Rheological Properties and Self-assembly Behaviourmentioning

confidence: 99%

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Novel thermoresponsive polymer outperforming Pluronic® F127

Constantinou¹,

Nele²,

Doutch³

et al. 2020

Preprint

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Thermoresponsive polymers featuring the appropriate combination of structural characteristics, i.e. architecture, composition, and molar mass (MM), can form physically crosslinked networks in a solvent upon changes in temperature. This fascinating class of polymers finds utility in various sectors such as formulation science and tissue engineering. Here, we report a novel thermoresponsive triblock terpolymer which out-performs the most commonly used and commercially available thermoresponsive polymer, Poloxamer P407 (also known as Pluronic® F127) in terms of gelation concentration. Specifically, the in-house synthesised polymer forms gels at lower concentrations that is an advantage in biomedical applications. To elucidate the differences in their macroscale gelling behaviour, we investigate their micellization via differential scanning calorimetry, and their nanoscale self-assembly behaviour in detail by means of small-angle neutron scattering by simultaneously recording their rheological properties (Rheo-SANS). Two different gelation mechanisms for the two polymers are revealed and proposed. Ex vivo gelation study upon intracameral injections demonstrated excellent potential for its application to improve drug residence in the eye.

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Section: Design and Thermal Properties In-house Synthesised Polymersupporting

confidence: 61%

Section: Design and Thermal Properties In-house Synthesised Polymersupporting

confidence: 56%

Section: Design and Thermal Properties In-house Synthesised Polymermentioning

confidence: 99%

Section: Rheological Properties and Self-assembly Behaviourmentioning

confidence: 99%

See 2 more Smart Citations

Novel thermoresponsive polymer outperforming Pluronic® F127

Constantinou¹,

Nele²,

Doutch³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Recently, highly tough hydrogels from PNIPAAm and alginate composites whose surfaces were modified by chitosan and carbodiimide crosslinker for adhesive and contacting via body temperature which accelerate wound healing in-vivo in mice has been reported. Another example of thermosensitive hydrogels are Pluronics are polyethylene oxide-based triblock copolymers, known for their bioadhesion, stability and thermosensitive gel forming capability at 30 • C, and are commonly used for injectable drug delivery systems [15]. In addition, polyurethane based hydrogels constituted by poly(glycerol-sebacate) and poly(ethylene-glycol) having thermo-reversibility between 5 and 37 • C has been reported.…”

Section: Introductionmentioning

confidence: 99%

In-Situ Forming pH and Thermosensitive Injectable Hydrogels to Stimulate Angiogenesis: Potential Candidates for Fast Bone Regeneration Applications

Kocak

Talari

Yar

et al. 2020

IJMS

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Biomaterials that promote angiogenesis are required for repair and regeneration of bone. In-situ formed injectable hydrogels functionalised with bioactive agents, facilitating angiogenesis have high demand for bone regeneration. In this study, pH and thermosensitive hydrogels based on chitosan (CS) and hydroxyapatite (HA) composite materials loaded with heparin (Hep) were investigated for their pro-angiogenic potential. Hydrogel formulations with varying Hep concentrations were prepared by sol–gel technique for these homogeneous solutions were neutralised with sodium bicarbonate (NaHCO3) at 4 °C. Solutions (CS/HA/Hep) constituted hydrogels setting at 37 °C which was initiated from surface in 5–10 minutes. Hydrogels were characterised by performing injectability, gelation, rheology, morphology, chemical and biological analyses. Hydrogel solutions facilitated manual dropwise injection from 21 Gauge which is highly used for orthopaedic and dental administrations, and the maximum injection force measured through 19 G needle (17.191 ± 2.296N) was convenient for manual injections. Angiogenesis tests were performed by an ex-ovo chick chorioallantoic membrane (CAM) assay by applying injectable solutions on CAM, which produced in situ hydrogels. Hydrogels induced microvascularity in CAM assay this was confirmed by histology analyses. Hydrogels with lower concentration of Hep showed more efficiency in pro-angiogenic response. Thereof, novel injectable hydrogels inducing angiogenesis (CS/HA/Hep) are potential candidates for bone regeneration and drug delivery applications.

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Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Gosecka

Gosecki

Jaworska‐Krych

2023

Adv Funct Materials

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Hydrogels, as 3D networks containing huge amount of water, display similarity to soft tissues, and thus they are of wide interest in tissue engineering. Hydrogels, due to biocompatibility and porous structure, are valuable therapeutic platforms for hydrophilic drugs. Over the last decade, there has been a strong emphasis on the development of hydrogel platforms with the ability to increase the solubility of hydrophobic drugs. However, the pronounced discrepancy between the hydrophilic character of hydrogels and the hydrophobic nature of numerous pharmacologically active compounds is problematic. In recent years, different strategies are applied using special polymer constructs or composite materials exploiting the advanced scientific knowledge in the area of polymer and lipid‐based nano‐ and microcarriers hydrophobization of the hydrogel turns out to be not only valuable in terms of achieving the ability to dissolve poorly soluble drugs in water, but also proves to be crucial in obtaining bioadhesion in wet conditions, but also, unexpected abnormal water swelling behavior, as well as in mechanical properties such as the dissipation mechanism and self‐healable hydrogel properties. This review is mainly focused on recent advances in the usage of hydrophobized hydrogels in biomedical applications.

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Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development

Cited by 186 publications

References 29 publications

Novel thermoresponsive polymer outperforming Pluronic® F127

Novel thermoresponsive polymer outperforming Pluronic® F127

In-Situ Forming pH and Thermosensitive Injectable Hydrogels to Stimulate Angiogenesis: Potential Candidates for Fast Bone Regeneration Applications

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

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