Pluronic lecithin organogel as a topical drug delivery system

Pandey, Mohit S; Belgamwar, Veena S.; Gattani, Surendra G.; Surana, Sanjay J.; Tekade, Avinash R.

doi:10.3109/10717540903508961

Cited by 48 publications

(27 citation statements)

References 16 publications

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“…Various other systems have also been developed for delivery of active principles through the skin such as acyclovir-loaded poly(lactic-co-glycolic acid) (PLGA) topical microparticles (37)(38)(39), microsponges for topical delivery mupirocin (40), biodegradable PLGA microparticles in o/w and w/o cream (41), block copolymer nanoparticles (42), biodegradable nanoparticles (43), and PLA nanoparticles (44). Further, the strategies for vectorization of drug across the skin have been extended to polymeric gels like pluronic lecithin organogels (45), bioadhesive gels, etc. (46).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Tubular Micelles of Pluronic Lecithin Organogel for Transdermal Delivery of Sumatriptan

et al. 2010

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Abstract. The present work focuses on the preparation and evaluation of lecithin organogel system of thermoreversible polymer pluronic F127, which would enhance the stability and absorption of sumatriptan succinate across the skin. Formulations were developed with and without co-surfactant (pluronic F127). The prepared organogels were evaluated for its appearance, organoleptic characteristics, and feel upon application, homogeneity, occlusivenes, washability, pH, viscosity, spreadability, gel transition temperature of formulations. The formulations were also evaluated for drug content, in vitro drug diffusion properties and skin irritation testing. In vivo evaluation of formulations was carried out by hot plate and writhing test method, and finally the optimized formulation was subjected to stability studies. The developed formulations were easily washable, smooth in feel, and showed no clogging which indicate superior texture of system. Formulation, containing pluronic showed greater spreadability and higher drug diffusion rate as compared to pluronic free organogel. Drug content of organogel formulations was in the range of 94-97%. The pH of the formulations was 6.48±0.5 and 6.98±0.1, reflecting no risk of skin irritation. Pluronic not only enhances the stability of organogel by increasing the viscosity (from 6,541±234.76 to 7,826±155.65 poise) but also increases the release of drug from 67.39± 1.53% to 74.21±1.7%. The sumatriptan exhibits higher and long lasting antinociceptive effect as indicated by the persistent increase in reaction time in hot plate and inhibited abdominal contraction in acetic acid-induced writhing test (p<0.05). The prepared optimized formulation was found to be stable without any significant changes at room temperature.

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Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Tubular Micelles of Pluronic Lecithin Organogel for Transdermal Delivery of Sumatriptan

et al. 2010

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“…14,15 In this study, the influence of two gel formulations on the transdermal penetration characteristics of caffeine was investigated. 16 The Pluronic Ò lecithin organo gel is a phospholipidic polymeric topical gel, recently developed and marketed for transdermal applications, claiming enhanced skin permeation and absorption of drugs 17,18 with lecithin acting as a penetration enhancer on the skin. The carbomer gel is a classic base, which often contains a high percentage of ethanol as well as PG, well-known skin penetration enhancers.…”

Section: Transdermal Caffeinementioning

confidence: 99%

Transdermal Evaluation of Caffeine in Different Formulations and Excipients

Veryser

Boonen

Mehuys

et al. 2013

Journal of Caffeine Research

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Background: The stratum corneum (SC) forms a difficult physical barrier for drugs to pass through the skin. Several strategies were developed to overcome this barrier. Optimization of topical drug formulations by selected excipients may facilitate the penetration of drugs through the SC into the viable skin cells and ultimately into the systemic circulation. Methods: Here, both the influence of two formulations (a classic carbomer-based gel and a novel Pluronic Ò lecithin organo gel (PLO gel)) and selected excipients (ethanol, propylene glycol, diethylene glycol monoethyl ether, isopropyl myristate (IPM), and water) with or without the penetration enhancer miconazole nitrate on the transdermal penetration characteristics of caffeine were determined using an in vitro Franz diffusion cell setup. Results: Higher fluxes were observed for the carbomer-based gel compared to the PLO gel. Among the commonly used excipients, IPM showed the best penetration enhancing properties, while the presence of the penetration enhancer miconazole nitrate did not significantly alter the apparent skin permeation characteristics for caffeine. Conclusion: The high ethanol percentage in the carbomer-based gel could explain the results as supported by our excipient data. Moreover, IPM could play a beneficial role in topical formulations as this excipient was responsible for a significant increase in the amount of caffeine penetrated through the skin. No overall statistical significant effect of the presence of miconazole nitrate as a penetration enhancer was observed.

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“…Благодаря своему строению и свойствам микроэмульсии способны иммобилизовывать водо-и маслорастворимые компоненты (например, лекарства) в одну из своих несмешивающихся фаз с последующим их пролонгированным выде-лением [10][11][12]. Они могут усиливать действие лекарственных препаратов, защищать инкорпори-рованные в них вещества от деградации, использоваться для захвата токсичных веществ из разбавленной дисперсионной среды во внут-реннюю дисперсную фазу в процессах очистки, служить премиксом при получении микро-и нанокапсул [10][11][12].…”

Section: Introductionunclassified

“…Они могут усиливать действие лекарственных препаратов, защищать инкорпори-рованные в них вещества от деградации, использоваться для захвата токсичных веществ из разбавленной дисперсионной среды во внут-реннюю дисперсную фазу в процессах очистки, служить премиксом при получении микро-и нанокапсул [10][11][12]. Лиотропные жидкие кристаллы могут использоваться в качестве анизотропных матриц для получения упорядо-ченных нанообъектов [13].…”

Section: Introductionunclassified

Phase Transitions and Supramolecular Organization in the Water / Ethoxylated Izononilfenol : Polyglyceryl-3 Methylglucose Distearate / Vaseline Oil System

Sautina¹,

Galyametdinov²

2016

Liq. Cryst. and their Appl.

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Pluronic lecithin organogel as a topical drug delivery system

Cited by 48 publications

References 16 publications

Preparation and Evaluation of Tubular Micelles of Pluronic Lecithin Organogel for Transdermal Delivery of Sumatriptan

Preparation and Evaluation of Tubular Micelles of Pluronic Lecithin Organogel for Transdermal Delivery of Sumatriptan

Transdermal Evaluation of Caffeine in Different Formulations and Excipients

Phase Transitions and Supramolecular Organization in the Water / Ethoxylated Izononilfenol : Polyglyceryl-3 Methylglucose Distearate / Vaseline Oil System

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