Plutonium-239 Deposition in the Skeleton of the Mouse

Green, D.; Howells, G.R.; Thorne, M C

doi:10.1080/09553007814550601

Cited by 17 publications

(2 citation statements)

References 8 publications

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“…Sections of the femora attached to Lexan and CR 39 slides were used for FTA (Green, Howells & Thorne, 1978a;Green, Howells & Priest, 1982). These were sandwiched with plastic backing slides and assembled with adhesive tape into small packs each containing several slides.…”

Section: Fission-track Autoradiography (Fta)mentioning

confidence: 99%

Uranium in Bone: Metabolic and Autoradiographic Studies in the Rat

Priest¹,

Howells²,

Green³

et al. 1982

Human Toxicology

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The distribution and retention of intravenously injected hexavalent uranium-233 in the skeleton of the female rat has been investigated using a variety of autoradiographic and radiochemical techniques. These showed that approximately one third of the injected uranium is deposited in the skeleton where it is retained with an initial biological half-time of ∼40 days. The studies also showed that: 1 Uranium is initially deposited onto all types of bone surface, but preferentially onto those that are accreting. 2 Uranium is deposited in the calcifying zones of skeletal cartilage. 3 Bone accretion results in the burial of surface deposits of uranium. 4 Bone resorption causes the removal of uranium from surfaces. 5 Resorbed uranium is not retained by osteoclasts and macrophages in the bone marrow. 6 Uranium removed from bone surfaces enters the bloodstream where most is either redeposited in bone or excreted via the kidneys. 7 The recycling of resorbed uranium within the skeleton tends to produce a uniform level of uranium contamination throughout mineralized bone. These results are taken to indicate that uranium deposition in bone shares characteristics in common with both the 'volume-seeking radionuclides' typified by the alkaline earth elements and with the 'bone surface-seeking radionuclides' typified by plutonium.

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Section: Fission-track Autoradiography (Fta)mentioning

confidence: 99%

Uranium in Bone: Metabolic and Autoradiographic Studies in the Rat

Priest¹,

Howells²,

Green³

et al. 1982

Human Toxicology

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“…Discussion ' Pattern of uptake The results of the present experiments show that most of the 226 Ra deposited in the rat skeleton is present as a volume deposit and is fairly evenly distributed throughout the bone matrix. This pattern of uptake is very different to that described for other a-emitting bone-seeking radionuclides such as 239pu (Green et al, 1978;Jee, 1972;Priest & Giannola, (1980),241Am (Polig, 1978;Priest et al, 1982b) and 233U (Stevens et al, 1980;Priest et al, 1982a) which deposit almost exclusively on bone surfaces. The attachment of 226 Ra to the bone matrix must in part be reversible as in excess of 20 % of the bone radium is lost to excretion within the first four days after its injection.…”

Section: Gross Skeletal Distribution Studymentioning

confidence: 55%

Autoradiographic Studies of the Distribution of Radium-226 in Rat Bone: Their Implications for Human Radiation Dosimetry and Toxicity

Priest¹,

Howells

Green

et al. 1983

Human Toxicology

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A solution containing 226Ra chloride was injected into young female rats via the saphenous vein. Subsequently, the distribution and retention of the 226Ra in the skeleton was studied. The results show that: 1226Ra is initially deposited in the rat femur as a volume deposit and is fairly evenly distributed throughout the bone matrix. 2 Much of the 226Ra initially deposited in the skeleton is lost within a few days of its administration. 3 During the first week 226Ra gradually accumulates at sites of bone deposition including accreting surfaces. 4 Subsequent bone growth results in the burial of contaminated bone surfaces and 5 Following bone resorption some of the 226Ra released from individual bones is recycled systemically so that all skeletal components tend towards a uniform 226Ra concentration per unit of bone mineral. Of the two models conventionally used for radiation dosimetry purposes, the results reported here for rats suggest that though neither is ideal, the volume distribution model is preferable to the surface model at all times after the uptake of radium by the skeleton.