The Sudanian-Sahelian zone of the Far-North Cameroon faces an extreme climate challenge resulting in increased vulnerability to erosion, soil degradation, and the effects of climate change, impacting soil fertility and agricultural yields. The objective of this study was to analyze agricultural practices, challenges related to climate change and soil degradation, as well as the solutions adopted by farmers to address these issues. To achieve this, 600 farmers from the six departments of the region were interviewed. The results highlight the significant impact of climatic conditions on soil health, agricultural activities, and food security. Farmers identified various indicators of soil degradation, including agricultural yields, bioindicator plants, plant growth, soil fauna, and root density. The main causes of soil degradation are associated with practices such as deforestation, intensive agriculture, the use of chemical fertilizers and pesticides, overgrazing, and the effects of climate change. The impacts of this degradation are multiple, including soil fertility loss, reduced agricultural yields, deforestation, reduced biodiversity, income loss, water resource pollution, and food insecurity. In response to these challenges, farmers have adopted sustainable soil management practices, including crop rotation, intercropping, fallowing, the use of organic fertilizers, and the adoption of conservation agriculture. To effectively address these challenges, concerted collaboration between farmers, civil society organizations, and government authorities is imperative to develop sustainable and effective solutions against soil degradation in the region.