PM052 The effect of high-intensity exercise and testosterone supplementation in men with heart failure

Mara, Lourenço Sampaio de; Lineburge, Alexandra A.; Ulbrich, Anderson Zampier; Pacheco, Juliano Anderson; Filho, Jamil Mattar Valente; Ribeiro, Eduardo Pontual; Sties, Sabrina Weiss; Gonzáles, Ana Inês; Carvalho, Tales de

doi:10.1016/j.gheart.2014.03.1462

Cited by 2 publications

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“…Two studies utilized transdermal formulations, and 1 study did not specify the type of testosterone used. [23][24][25] The transdermal studies used doses of 5 mg daily and 300 mcg twice weekly, respectively. 23,24 All of the studies excluded women with the exception of one (n = 36).…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…[18][19][20][21][22][23] Details on baseline HF medications were reported in 6 studies; doses of these agents were not reported. 18,19,[21][22][23][24] Demographic information is listed in Table 1, 11,[17][18][19][20][21][22][23][24][25] and the results of the studies are presented in Table 2. 11,[17][18][19][20][21][22][23][24][25]…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

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The Role of Testosterone in Patients With Heart Failure: A Systematic Review

Park

Gale

Watson

2020

Cardiology in Review

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The consequences of heart failure (HF) remain high despite treatment advances. Deficiency of the anabolic axes is common in HF and is associated with an increased risk of death and worsening functional status. Exogenous testosterone use has been shown to decrease vascular resistance and improve cardiac output. The objective of this systematic review was to assess the efficacy (mortality, hospitalization, cardiac function, and quality of life) and safety of testosterone in HF patients. The Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines were followed. Four electronic databases were searched from inception until November 30, 2019. The initial search yielded 1308 articles, and 10 randomized controlled trials with exogenous testosterone in patients with HF were included after exclusion criteria were applied. One study evaluated the impact of testosterone on mortality and HF hospitalization; no difference was observed compared with placebo. In 5 studies, testosterone use was associated with an improvement in walking distance. In 1 of the 2 studies that evaluated functional status, New York Heart Association class was improved. In 2 out of 4 studies, quality of life was improved with therapy. When reported, testosterone use was not associated with an increase in side effects. Overall, testosterone use has not been shown to reduce the risk of death or HF hospitalization, with inconsistent evidence on the impact of therapy on quality of life. Additional trials are needed before testosterone can be recommended. Patients with HF should receive guideline-directed medical therapy with the assurance that patients are receiving maximum tolerated doses.

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

The Role of Testosterone in Patients With Heart Failure: A Systematic Review

Park

Gale

Watson

2020

Cardiology in Review

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show abstract

“…A avaliação da QVRS feita com instrumentos específicos para a doença apresentada é mais significativa na constatação de alterações postas pelos sinais e sintomas das enfermidades . Na avaliação da QVRS de portadores de IC o questionário MLHFQ vem sendo utilizado em diversas publicações (AUSTIN et al, 2008;ARNOLD et al, 2012;BARBOSA et al, 2014;GOMES-NETO et al, 2014;MARA et al, 2014;ALVAREZ et al, 2016;VAILLANT-ROUSSEL et al, 2016;GONZALEZ, 2016;AHMETI et al, 2017;KULARATNA et al, 2017;ESCOBAR et al 2017). Como já mencionado, o instrumento de avaliação é composto por 21 itens, com escalas de pontuação que variam de 0 a 5 pontos e que são estratificados em três domínios: dificuldade física (0 -45 pontos); emocional (0 -25 pontos) e aspectos inespecíficos (0 -35 pontos).…”

Section: Qualidade De Vida Relacionada á Saúdeunclassified

“…No que tange ao âmbito emocional analisado no presente estudo, houve variação de escores entre 9 e 11 pontos. Publicações nacionais e internacionais refletem resultados discrepantes quanto a este aspecto (SANTOS; PLEWKA; BROFMAN, 2009;GALLANI, 2011;HANSON et al, 2013;MORAIS, 2014;MARA et al, 2014;GONZALEZ, 2016;AHMETI et al, 2017;ESCOBAR et al, 2017).…”

Section: Qualidade De Vida Relacionada á Saúdeunclassified

“…Os escores do "Domínio Inespecífico" aumentaram significativamente ao longo do estudo quando comparados estatisticamente sendo superiores à média encontrada em outros registros (SANTOS; PLEWKA; BROFMAN, 2009;MARA et al, 2014;CONCEIÇÃO, 2015). São poucos os estudos que consideraram os aspectos inespecíficos em suas discussões (CRUZ, 2010;MARA et al, 2014).…”

Section: Qualidade De Vida Relacionada á Saúdeunclassified

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Perfil epidemiológico, aptidão cardiopulmonar e qualidade de vida relacionada à saúde de pacientes com insuficiência cardíaca

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PM052 The effect of high-intensity exercise and testosterone supplementation in men with heart failure

Cited by 2 publications

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The Role of Testosterone in Patients With Heart Failure: A Systematic Review

The Role of Testosterone in Patients With Heart Failure: A Systematic Review

Perfil epidemiológico, aptidão cardiopulmonar e qualidade de vida relacionada à saúde de pacientes com insuficiência cardíaca

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