PM1 exposure and spatial transmission of nicotine from the simulated second-hand vapor of pod-based electronic cigarettes

Cui, Tong; Lü, Rui; Liu, Qianyun; Jiang, Xingtao; Li, Yanpeng; Song, Peng

doi:10.1016/j.scitotenv.2023.165355

Cited by 5 publications

(1 citation statement)

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“…6). Current studies of potential impact of secondhand vaping on indoor air quality are primarily focusing on compositional analysis of the emission, while this study is one of the few that demonstrates real-life personal exposure scenarios by conducting a comparative analysis between rsthand and secondhand with pu ng topography pro le-matched data (10,20,55) and metabolomic outcomes associated with each exposure scenario. Moreover, the calculated vital capacity (VC) and forced vital capacity (FVC) did not show signi cant differences among the low, medium, and high puff volume groups (Fig.…”

Section: Discussionmentioning

confidence: 99%

The Role of Puff Volume in Vaping Emissions, Inhalation Risks, and Metabolic Perturbations: A Pilot Study

Jeon,

He,

Shinde

et al. 2024

Preprint

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Secondhand vaping exposure is an emerging public health concern that remains understudied. In this study, saliva and exhaled emissions from ENDS users (secondhand) and non-ENDS users (baseline) were collected, firsthand emissions were generated using an automated ENDS aerosol generation system programmed to simulate puffing topography profiles collected from ENDS users. Particulate concentrations and sizes along with volatile organic compounds were characterized. We revealed puffing topography metrics as potential mediators of firsthand and secondhand particle and chemical exposures, as well as metabolic and respiratory health outcomes. Particle deposition modeling revealed that while secondhand emissions displayed smaller deposited mass, total and pulmonary particle deposition fractions were higher than firsthand deposition levels, possibly due to smaller secondhand emission particle diameters. Lastly, untargeted metabolomic profiling of salivary biomarkers of lung injury due to firsthand ENDS exposures revealed potential early indicators of respiratory distress that may also be relevant in bystanders exposed to secondhand vaping scenarios. By leveraging system toxicology, we identified 10 metabolites, including leukotriene D4, that could potentially serve as biomarkers for ENDS use, exposure estimation, and the prediction of vaping-related disease. This study highlights characterization of vaping behavior is an important exposure component in advancing our understanding of potential health effects in ENDS users and bystanders.

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Section: Discussionmentioning

confidence: 99%