PMS24 A Systematic Review of Existing Utility Weight Estimates in Rheumatoid Arthritis

Feng, JingYuan; Campbell, Stephanie; Norris, Sheena M. Posey

doi:10.1016/j.jval.2012.08.425

Cited by 1 publication

(2 citation statements)

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“…Health state utility values are pivotal for CUA for which local utility data is preferred to obtain more robust results. Previous systematic reviews were primarily based on the EQ‐5D studies from Central and Eastern European countries, 20 or from Australia 21 . Further, the existing systematic reviews 20,21 have not explored the utility scores of RA unique to different disease activities.…”

Section: Introductionmentioning

confidence: 99%

“…Previous systematic reviews were primarily based on the EQ-5D studies from Central and Eastern European countries, 20 or from Australia. 21 Further, the existing systematic reviews 20,21 have not explored the utility scores of RA unique to different disease activities. Despite numerous primary studies on RA-EQ-5D in Asian countries, [22][23][24] a SRMA (Systematic Review and Meta-Analysis) specific to Asian countries is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Health‐related quality of life in rheumatoid arthritis: Systematic review and meta‐analysis of EuroQoL (EQ‐5D) utility scores from Asia

2021

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Introduction Region‐specific health‐related quality of life (HRQoL) scores or utility values are representative and pivotal for economic evaluations as they are influenced by the value judgment of the local population. This study systematically reviewed and pooled EuroQoL‐5 Dimension (EQ‐5D) utility scores of rheumatoid arthritis (RA) across primary studies from Asia. Methods Studies reporting EQ‐5D utility scores among adult RA patients from Asian countries were systematically searched in PubMed‐Medline, Scopus and Embase since inception through February 2020. Selected studies were systematically reviewed and study quality assessment was performed. Meta‐analysis was performed using a random‐effect model with subgroup and meta‐regression analysis to explore heterogeneity. Results Among 1391 searched articles, 37 studies with 31 983 participants were systematically reviewed and meta‐analysis was conducted among 31 studies. The pooled EQ‐5D scores and EQ‐5D visual analog score were 0.66 (95% CI 0.63‐0.69, I2 = 99.65%) and 61.21 (50.73‐71.69, I2 = 99.56%) respectively with high heterogeneity. For RA patients with no, low, moderate and high disease activity based on Disease Activity Score (DAS)‐28, the pooled EQ‐5D scores were 0.78 (0.65‐0.90), 0.73 (0.65‐0.80), 0.53 (0.32‐ 0.74), and 0.47 (0.32‐0.62), respectively. On meta‐regression, age of patients (P < .05) was positively associated and use of glucocorticoids (P < .05) was inversely associated with utility values. Conclusion Lower EQ‐5D scores were associated with severe disease activity, increasing age and female gender among RA patients. The study provides pooled EQ‐5D scores for RA patients that are useful inputs for cost‐utility studies in Asia.

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Section: Introductionmentioning

confidence: 99%