2023
DOI: 10.20944/preprints202308.1414.v1
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PNA6, a Lactosyl Analogue of Angiotensin-(1—7), Reverses Pain Induced in Murine Models of Inflammation, Metastatic Bone Disease, and Chemotherapy-Induced Peripheral Neuropathy

Maha Sulaiman,
Wafaa Alabsi,
Lajos Szabo
et al.

Abstract: The renin-angiotensin system (RAS) plays a role in cardiovascular homeostasis and hydro-electrolyte balance influencing organ function throughout the body. The classical view of RAS focused on a single biologically active metabolite, the octapeptide angiotensin (Ang)ll, created by the Angiotensin-converting enzyme (ACE). The past two decades have revealed new functions for intermediate products of the RAS beyond their role as substrates. Angiotensin 1-7 (Ang-(1—7), a RAS peptide product with actions at the Mas… Show more

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