“…In a recent study by Gagne et al, compared with matched patients without migraine, patients with migraine reported higher lifetime rates of comorbidities such as arthritis, gastroesophageal reflux disease, depression, hypercholesterolemia, hypertension, and general anxiety, as well as more visits to health-care providers. 20 Interestingly, the comorbidity and psychiatric indexes in the present study were similar between postmatch migraine and control cohorts; however, the nonmigraine costs were still substantially higher in the migraine cohort.…”